Publications

• 1. Kris Emo
  2. Emma C. Reilly
  3. Mike Sportiello
  4. Hongmei Yang
  5. Topham DJ 
  T cell and chemokine receptors differentially control CD8 T cell motility behavior in the infected airways immediately before and after virus clearance in a primary infection; PLOS ONE. August 20, 2020
• 1. Emma C. Reilly
  2. Kris Lambert Emo
  3. Patrick M. Buckley
  4. Nicholas S. Reilly
  5. Ian Smith
  6. Francisco A. Chaves
  7. Hongmei Yang
  8. Patrick W. Oakes
  9. Topham DJ 
  TRM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection; PNAS June 2, 2020 117 (22) 12306-12314
• 1. Capece T
  2. Walling BL
  3. Lim K
  4. Kim KD
  5. Bae S
  6. Chung HL
  7. Topham DJ
  8. Kim M 
  A novel intracellular pool of LFA-1 is critical for asymmetric CD8(+) T cell activation and differentiation.; The Journal of cell biology. 2017 Sep 27.
• 1. Gaylo A
  2. Overstreet MG
  3. Fowell DJ 
  Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis.; Journal of visualized experiments : JoVE. 2016.
• 1. Billroth-MacLurg AC
  2. Ford J
  3. Rosenberg A
  4. Miller J
  5. Fowell DJ 
  Regulatory T Cell Numbers in Inflamed Skin Are Controlled by Local Inflammatory Cues That Upregulate CD25 and Facilitate Antigen-Driven Local Proliferation.; Journal of immunology (Baltimore, Md. : 1950). 2016 Aug 10.
• 1. Lambert Emo K
  2. Hyun YM
  3. Reilly E
  4. Barilla C
  5. Gerber S
  6. Fowell D
  7. Kim M
  8. Topham DJ 
  Live Imaging of Influenza Infection of the Trachea Reveals Dynamic Regulation of CD8+ T Cell Motility by Antigen.; PLoS pathogens; Vol 12(9). 2016 Sep.
• 1. Gaylo A
  2. Schrock DC
  3. Fernandes NR
  4. Fowell DJ 
  T Cell Interstitial Migration: Motility Cues from the Inflamed Tissue for Micro- and Macro-Positioning.; Frontiers in immunology; Vol 7. 2016.
• 1. Reilly EC
  2. Lambert-Emo K
  3. Topham DJ 
  The Effects of Acute Neutrophil Depletion on Resolution of Acute Influenza Infection, Establishment of Tissue Resident Memory (TRM), and Heterosubtypic Immunity.; PloS one; Vol 11(10). 2016.
• 1. Tankam P
  2. He Z
  3. Chu YJ
  4. Won J
  5. Canavesi C
  6. Lepine T
  7. Hindman HB
  8. Topham DJ
  9. Gain P
  10. Thuret G
  11. Rolland JP
  (2015 Mar 15). Assessing microstructures of the cornea with Gabor-domain optical coherence microscopy: pathway for corneal physiology and diseases.Opt Lett. 40, 1113-6.
• 1. Lim K
  2. Hyun YM
  3. Lambert-Emo K
  4. Capece T
  5. Bae S
  6. Miller R
  7. Topham DJ
  8. Kim M
  (2015 Sep 04). Neutrophil trails guide influenza-specific CD8⁺ T cells in the airways.Science. 349, aaa4352.
• 1. Lim K
  2. Hyun YM
  3. Lambert-Emo K
  4. Topham DJ
  5. Kim M
  (2015 Nov 01). Visualization of integrin Mac-1 in vivo.J Immunol Methods. 426, 120-7.
• 1. Haynes-Gimore N
  2. Banach M
  3. Brown E
  4. Dawes R
  5. Edholm ES
  6. Kim M
  7. Robert J
  (2015 Dec 15). Semi-solid tumor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration.Dev Biol. 408, 205-12.
• 1. Scheible KM
  2. Emo J
  3. Yang H
  4. Holden-Wiltse J
  5. Straw A
  6. Huyck H
  7. Misra S
  8. Topham DJ
  9. Ryan RM
  10. Reynolds AM
  11. Mariani TJ
  12. Pryhuber GS
  (2015 Dec 01). Developmentally determined reduction in CD31 during gestation is associated with CD8+ T cell effector differentiation in preterm infants.Clin Immunol. 161, 65-74.
• 1. Lim K
  2. Hyun YM
  3. Lambert-Emo K
  4. Topham DJ
  5. Kim M
  (2015 Nov 01). Visualization of integrin Mac-1 in vivo.J Immunol Methods. 426, 120-7.
• 1. Halliley JL
  2. Khurana S
  3. Krammer F
  4. Fitzgerald T
  5. Coyle EM
  6. Chung KY
  7. Baker SF
  8. Yang H
  9. Martínez-Sobrido L
  10. Treanor JJ
  11. Subbarao K
  12. Golding H
  13. Topham DJ
  14. Sangster MY
  (2015 Oct 15). High-Affinity H7 Head and Stalk Domain-Specific Antibody Responses to an Inactivated Influenza H7N7 Vaccine After Priming With Live Attenuated Influenza Vaccine.J Infect Dis. 212, 1270-8.
• 1. Rangel-Moreno J
  2. de la Luz Garcia-Hernandez M
  3. Ramos-Payan R
  4. Biear J
  5. Hernady E
  6. Sangster MY
  7. Randall TD
  8. Johnston CJ
  9. Finkelstein JN
  10. Williams JP
  (2015 Oct 01). Long-Lasting Impact of Neonatal Exposure to Total Body Gamma Radiation on Secondary Lymphoid Organ Structure and Function.Radiat Res. 184, 352-66.
• 1. Lim K
  2. Hyun YM
  3. Lambert-Emo K
  4. Capece T
  5. Bae S
  6. Miller R
  7. Topham DJ
  8. Kim M
  (2015 Sep 04). Neutrophil trails guide influenza-specific CD8⁺ T cells in the airways.Science. 349, aaa4352.
• 1. Boule LA
  2. Winans B
  3. Lambert K
  4. Vorderstrasse BA
  5. Topham DJ
  6. Pavelka MS
  7. Lawrence BP
  (2015 Aug 01). Activation of the aryl hydrocarbon receptor during development enhances the pulmonary CD4+ T-cell response to viral infection.Am J Physiol Lung Cell Mol Physiol. 309, L305-13.
• 1. Baker SF
  2. Nogales A
  3. Santiago FW
  4. Topham DJ
  5. Martínez-Sobrido L
  (2015 Jul 09). Competitive detection of influenza neutralizing antibodies using a novel bivalent fluorescence-based microneutralization assay (BiFMA).Vaccine. 33, 3562-70.
• 1. Yang H
  2. Baker SF
  3. González ME
  4. Topham DJ
  5. Martínez-Sobrido L
  6. Zand M
  7. Holden-Wiltse J
  8. Wu H
  (2015 May 26). An improved method for estimating antibody titers in microneutralization assay using green fluorescent protein.J Biopharm Stat, 1-12.
• 1. Misra RS
  2. Shah S
  3. Fowell DJ
  4. Wang H
  5. Scheible K
  6. Misra SK
  7. Huyck H
  8. Wyman CP
  9. Ryan RM
  10. Reynolds AM
  11. Mariani TJ
  12. Katzman PJ
  13. Pryhuber GS
  (2015 May 01). Preterm cord blood CD4⁺ T cells exhibit increased IL-6 production in chorioamnionitis and decreased CD4⁺ T cells in bronchopulmonary dysplasia.Hum Immunol. 76, 329-38.
• 1. Wu H
  2. Miao H
  3. Xue H
  4. Topham DJ
  5. Zand M
  (2015 May 01). Quantifying Immune Response to Influenza Virus Infection via Multivariate Nonlinear ODE Models with Partially Observed State Variables and Time-Varying Parameters.Stat Biosci. 7, 147-166.
• 1. Lee AJ
  2. Das SR
  3. Wang W
  4. Fitzgerald T
  5. Pickett BE
  6. Aevermann BD
  7. Topham DJ
  8. Falsey AR
  9. Scheuermann RH
  (2015 May 01). Diversifying Selection Analysis Predicts Antigenic Evolution of 2009 Pandemic H1N1 Influenza A Virus in Humans.J Virol. 89, 5427-40.
• 1. Na BR
  2. Kim HR
  3. Piragyte I
  4. Oh HM
  5. Kwon MS
  6. Akber U
  7. Lee HS
  8. Park DS
  9. Song WK
  10. Park ZY
  11. Im SH
  12. Rho MC
  13. Hyun YM
  14. Kim M
  15. Jun CD
  (2015 Apr 13). TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.J Cell Biol. 209, 143-62.
• 1. Tankam P
  2. He Z
  3. Chu YJ
  4. Won J
  5. Canavesi C
  6. Lepine T
  7. Hindman HB
  8. Topham DJ
  9. Gain P
  10. Thuret G
  11. Rolland JP
  (2015 Mar 15). Assessing microstructures of the cornea with Gabor-domain optical coherence microscopy: pathway for corneal physiology and diseases.Opt Lett. 40, 1113-6.
• 1. Sundararajan A
  2. Sangster MY
  3. Frey S
  4. Atmar RL
  5. Chen WH
  6. Ferreira J
  7. Bargatze R
  8. Mendelman PM
  9. Treanor JJ
  10. Topham DJ
  (2015 Jan 15). Robust mucosal-homing antibody-secreting B cell responses induced by intramuscular administration of adjuvanted bivalent human norovirus-like particle vaccine.Vaccine. 33, 568-76.
• 1. Lerman YV
  2. Kim M
  (2015 Jan 01). Neutrophil migration under normal and sepsis conditions.Cardiovasc Hematol Disord Drug Targets. 15, 19-28.
• 1. Ramon S
  2. Baker SF
  3. Sahler JM
  4. Kim N
  5. Feldsott EA
  6. Serhan CN
  7. Martínez-Sobrido L
  8. Topham DJ
  9. Phipps RP
  (2014 Dec 15). The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant?J Immunol. 193, 6031-40.
• 1. Lerman YV
  2. Lim K
  3. Hyun YM
  4. Falkner KL
  5. Yang H
  6. Pietropaoli AP
  7. Sonnenberg A
  8. Sarangi PP
  9. Kim M
  (2014 Dec 04). Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin α3β1-dependent.Blood. 124, 3515-23.
• 1. Babu TM
  2. Levine M
  3. Fitzgerald T
  4. Luke C
  5. Sangster MY
  6. Jin H
  7. Topham D
  8. Katz J
  9. Treanor J
  10. Subbarao K
  (2014 Nov 28). Live attenuated H7N7 influenza vaccine primes for a vigorous antibody response to inactivated H7N7 influenza vaccine.Vaccine. 32, 6798-804.
• 1. Guo H
  2. Baker SF
  3. Martínez-Sobrido L
  4. Topham DJ
  (2014 Oct 01). Induction of CD8 T cell heterologous protection by a single dose of single-cycle infectious influenza virus.J Virol. 88, 12006-16.
• 1. Baker SF
  2. Nogales A
  3. Finch C
  4. Tuffy KM
  5. Domm W
  6. Perez DR
  7. Topham DJ
  8. Martínez-Sobrido L
  (2014 Sep 01). Influenza A and B virus intertypic reassortment through compatible viral packaging signals.J Virol. 88, 10778-91.
• 1. Nogales A
  2. Baker SF
  3. Ortiz-Riaño E
  4. Dewhurst S
  5. Topham DJ
  6. Martínez-Sobrido L
  (2014 Sep 01). Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development.J Virol. 88, 10525-40.
• 1. Stevenson C
  2. de la Rosa G
  3. Anderson CS
  4. Murphy PS
  5. Capece T
  6. Kim M
  7. Elliott MR
  (2014 Jun 15). Essential role of Elmo1 in Dock2-dependent lymphocyte migration.J Immunol. 192, 6062-70.
• 1. Baik SH
  2. Cha MY
  3. Hyun YM
  4. Cho H
  5. Hamza B
  6. Kim DK
  7. Han SH
  8. Choi H
  9. Kim KH
  10. Moon M
  11. Lee J
  12. Kim M
  13. Irimia D
  14. Mook-Jung I
  (2014 Jun 01). Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model.Neurobiol Aging. 35, 1286-92.
• 1. Xu Y
  2. Hyun YM
  3. Lim K
  4. Lee H
  5. Cummings RJ
  6. Gerber SA
  7. Bae S
  8. Cho TY
  9. Lord EM
  10. Kim M
  (2014 Apr 29). Optogenetic control of chemokine receptor signal and T-cell migration.Proc Natl Acad Sci U S A. 111, 6371-6.
• 1. Polesskaya O
  2. Wong C
  3. Lebron L
  4. Chamberlain JM
  5. Gelbard HA
  6. Goodfellow V
  7. Kim M
  8. Daiss JL
  9. Dewhurst S
  (2014 Apr 01). MLK3 regulates fMLP-stimulated neutrophil motility.Mol Immunol. 58, 214-22.
• 1. Shi G
  2. Field DJ
  3. Ko KA
  4. Ture S
  5. Srivastava K
  6. Levy S
  7. Kowalska MA
  8. Poncz M
  9. Fowell DJ
  10. Morrell CN
  (2014 Feb 01). Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection.J Clin Invest. 124, 543-52.
• 1. Sanchez-Lockhart M
  2. Rojas AV
  3. Fettis MM
  4. Bauserman R
  5. Higa TR
  6. Miao H
  7. Waugh RE
  8. Miller J
  (2014 Jan 01). T cell receptor signaling can directly enhance the avidity of CD28 ligand binding.PLoS One. 9, e89263.
• 1. Miao H
  2. Sangster MY
  3. Livingstone AM
  4. Hilchey SP
  5. Zhang L
  6. Topham DJ
  7. Mosmann TR
  8. Holden-Wiltse J
  9. Perelson AS
  10. Wu H
  11. Zand MS
  (2014 Jan 01). Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection.PLoS One. 9, e104781.
• 1. Knowlden SA
  2. Capece T
  3. Popovic M
  4. Chapman TJ
  5. Rezaee F
  6. Kim M
  7. Georas SN
  (2014 Jan 01). Regulation of T cell motility in vitro and in vivo by LPA and LPA2.PLoS One. 9, e101655.
• 1. Berry CM
  2. Penhale WJ
  3. Sangster MY
  (2014 Jan 01). Passive broad-spectrum influenza immunoprophylaxis.Influenza Res Treat. 2014, 267594.
• 1. Alam S
  2. Knowlden ZA
  3. Sangster MY
  4. Sant AJ
  (2014 Jan 01). CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection.J Virol. 88, 314-24.
• 1. Chen J
  2. Pompano RR
  3. Santiago FW
  4. Maillat L
  5. Sciammas R
  6. Sun T
  7. Han H
  8. Topham DJ
  9. Chong AS
  10. Collier JH
  (2013 Nov 01). The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation.Biomaterials. 34, 8776-85.
• 1. Overstreet MG
  2. Gaylo A
  3. Angermann BR
  4. Hughson A
  5. Hyun YM
  6. Lambert K
  7. Acharya M
  8. Billroth-Maclurg AC
  9. Rosenberg AF
  10. Topham DJ
  11. Yagita H
  12. Kim M
  13. Lacy-Hulbert A
  14. Meier-Schellersheim M
  15. Fowell DJ
  (2013 Sep 01). Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV.Nat Immunol. 14, 949-58.
• 1. Fouchier RA
  2. Kawaoka Y
  3. Cardona C
  4. Compans RW
  5. García-Sastre A
  6. Govorkova EA
  7. Guan Y
  8. Herfst S
  9. Orenstein WA
  10. Peiris JS
  11. Perez DR
  12. Richt JA
  13. Russell C
  14. Schultz-Cherry SL
  15. Smith DJ
  16. Steel J
  17. Tompkins SM
  18. Topham DJ
  19. Treanor JJ
  20. Tripp RA
  21. Webby RJ
  22. Webster RG
  (2013 Aug 09). Gain-of-function experiments on H7N9.Science. 341, 612-3.
• 1. Fouchier RA
  2. Kawaoka Y
  3. Cardona C
  4. Compans RW
  5. Fouchier RA
  6. García-Sastre A
  7. Govorkova EA
  8. Guan Y
  9. Herfst S
  10. Kawaoka Y
  11. Orenstein WA
  12. Peiris JS
  13. Perez DR
  14. Richt JA
  15. Russell C
  16. Schultz-Cherry SL
  17. Smith DJ
  18. Steel J
  19. Tompkins SM
  20. Topham DJ
  21. Treanor JJ
  22. Tripp RA
  23. Webby RJ
  24. Webster RG
  (2013 Aug 08). Avian flu: Gain-of-function experiments on H7N9.Nature. 500, 150-1.
• 1. Fouchier RA
  2. Kawaoka Y
  3. Cardona C
  4. Compans RW
  5. García-Sastre A
  6. Govorkova EA
  7. Guan Y
  8. Herfst S
  9. Orenstein WA
  10. Peiris JS
  11. Perez DR
  12. Richt JA
  13. Russell C
  14. Schultz-Cherry SL
  15. Smith DJ
  16. Steel J
  17. Tompkins SM
  18. Topham DJ
  19. Treanor JJ
  20. Tripp RA
  21. Webby RJ
  22. Webster RG
  (2013 Aug 07). Gain-of-Function Experiments on H7N9.Science.
• 1. Batchu SN
  2. Hughson A
  3. Gerloff J
  4. Fowell DJ
  5. Korshunov VA
  (2013 Aug 01). Role of Axl in early kidney inflammation and progression of salt-dependent hypertension.Hypertension. 62, 302-9.
• 1. Baker SF
  2. Guo H
  3. Albrecht RA
  4. García-Sastre A
  5. Topham DJ
  6. Martínez-Sobrido L
  (2013 Aug 01). Protection against lethal influenza with a viral mimic.J Virol. 87, 8591-605.
• 1. Sangster MY
  2. Baer J
  3. Santiago FW
  4. Fitzgerald T
  5. Ilyushina NA
  6. Sundararajan A
  7. Henn AD
  8. Krammer F
  9. Yang H
  10. Luke CJ
  11. Zand MS
  12. Wright PF
  13. Treanor JJ
  14. Topham DJ
  15. Subbarao K
  (2013 Jun 01). B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza virus vaccination.Clin Vaccine Immunol. 20, 867-76.
• 1. Yu C
  2. Xu L
  3. Chen LF
  4. Guan YJ
  5. Kim M
  6. Biffl WL
  7. Chin YE
  (2013 Feb 01). PRBC-derived plasma induces non-muscle myosin type IIA-mediated neutrophil migration and morphologic change.Immunopharmacol Immunotoxicol. 35, 71-9.
• 1. He XS
  2. Sasaki S
  3. Baer J
  4. Khurana S
  5. Golding H
  6. Treanor JJ
  7. Topham DJ
  8. Sangster MY
  9. Jin H
  10. Dekker CL
  11. Subbarao K
  12. Greenberg HB
  (2013 Jan 15). Heterovariant cross-reactive B-cell responses induced by the 2009 pandemic influenza virus A subtype H1N1 vaccine.J Infect Dis. 207, 288-96.
• 1. Lazarski CA
  2. Ford J
  3. Katzman SD
  4. Rosenberg AF
  5. Fowell DJ
  (2013 Jan 01). IL-4 attenuates Th1-associated chemokine expression and Th1 trafficking to inflamed tissues and limits pathogen clearance.PLoS One. 8, e71949.
• 1. Yang H
  2. Topham DJ
  3. Holden-Wiltse J
  4. Wu H
  (2013 Jan 01). Statistical estimation & inference of cell counts from ELISPOT limiting dilution assays.J Biopharm Stat. 23, 921-36.
• 1. Scheible K
  2. Secor-Socha S
  3. Wightman T
  4. Wang H
  5. Mariani TJ
  6. Topham DJ
  7. Pryhuber G
  8. Quataert S
  (2012 Nov 01). Stability of T cell phenotype and functional assays following heparinized umbilical cord blood collection.Cytometry A. 81, 937-49.
• 1. van Helden MJ
  2. van Kooten PJ
  3. Bekker CP
  4. Gröne A
  5. Topham DJ
  6. Easton AJ
  7. Boog CJ
  8. Busch DH
  9. Zaiss DM
  10. Sijts AJ
  (2012 Oct 05). Pre-existing virus-specific CD8(+) T-cells provide protection against pneumovirus-induced disease in mice.Vaccine. 30, 6382-8.
• 1. van Helden MJ
  2. de Graaf N
  3. Boog CJ
  4. Topham DJ
  5. Zaiss DM
  6. Sijts AJ
  (2012 Sep 01). The bone marrow functions as the central site of proliferation for long-lived NK cells.J Immunol. 189, 2333-7.
• 1. Sarangi PP
  2. Hyun YM
  3. Lerman YV
  4. Pietropaoli AP
  5. Kim M
  (2012 Aug 01). Role of β1 integrin in tissue homing of neutrophils during sepsis.Shock. 38, 281-7.
• 1. Chapman LM
  2. Aggrey AA
  3. Field DJ
  4. Srivastava K
  5. Ture S
  6. Yui K
  7. Topham DJ
  8. Baldwin WM
  9. Morrell CN
  (2012 Jul 15). Platelets present antigen in the context of MHC class I.J Immunol. 189, 916-23.
• 1. Hyun YM
  2. Sumagin R
  3. Sarangi PP
  4. Lomakina E
  5. Overstreet MG
  6. Baker CM
  7. Fowell DJ
  8. Waugh RE
  9. Sarelius IH
  10. Kim M
  (2012 Jul 02). Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels.J Exp Med. 209, 1349-62.