Garcia-Hernandez Lab
Unraveling the Contribution of DC-STAMP in Bone Resorption and Immunity
Osteoporosis drastically affects the quality of life in menopausal women and patients affected by rheumatic inflammatory diseases, has significant economic repercussions, and increases the mortality associated with fractures provoked as a result of pathological and exacerbated bone resorption. The focus of the laboratory is to understand the contribution of DC-STAMP in rheumatoid arthritis and psoriatic arthritis using a preclinical model of inflammatory arthritis. Our group has access to well-characterized clinical samples which facilitate the development of humanized mice to test palliative and therapeutic treatments to ameliorate the onset of arthritis.
Maria de la Luz Garcia-Hernandez, Ph.D.
Investigator
Publications
View All Publications- Evaluation of Vaccinia Virus Infection in Mice Using Two-Reporter Recombinant Virus.; Methods in molecular biology (Clifton, N.J.); Vol 2860, pp. 157-174. 2025.
- Single-cell RNA sequencing reveals placental response under environmental stress.; Nature communications; Vol 15(1), pp. 6549. 2024 Aug 02.
- Psoriatic arthritis subtypes are phenocopied in humanized mice.; JCI insight; Vol 9(15). 2024 Jul 02.
- IL-23 induces CLEC5A+ IL-17A+ neutrophils and elicit skin inflammation associated with psoriatic arthritis.; Journal of autoimmunity; Vol 143, pp. 103167. 2024 Jan 31.
Affiliations
News
May 23, 2025
AIR Research Presented at the 2025 AAI Meeting
May 23, 2025
Dr. Javier Rangel-Moreno Lecturer at the 2025 Course of Biomedicine and Immunology
January 15, 2025
ROChester Stimulating Access to Research during Residency (ROC StARR) Health and Immune Function Across the Lifespan to Begin July 1st
January 6, 2025
Jennifer Anolik Named Chief of Allergy, Immunology and Rheumatology Division
December 13, 2024
Ilana Abeles Receives Clinical Trial Investigator Award
Contact Us
Garcia-Hernandez Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642