Unraveling the Contribution of DC-STAMP in Bone Resorption and Immunity

Osteoporosis drastically affects the quality of life in menopausal women and patients affected by rheumatic inflammatory diseases, has significant economic repercussions, and increases the mortality associated with fractures provoked as a result of pathological and exacerbated bone resorption. The focus of the laboratory is to understand the contribution of DC-STAMP in rheumatoid arthritis and psoriatic arthritis using a preclinical model of inflammatory arthritis. Our group has access to well-characterized clinical samples which facilitate the development of humanized mice to test palliative and therapeutic treatments to ameliorate the onset of arthritis.