Cell Biology
Microbes and viruses interact with host cells to induce alterations in cellular phenotype and function, thereby subverting host cell metabolism to meet their own needs. In addition, many microbes and viruses exert effects on the host immune response, so as to evade host immune control. Knowledge of the interplay between infectious pathogens and their host cells is therefore important, in order to identify potential new targets for drug therapy and as a basis for understanding microbial pathogenesis. Research focuses on various aspects of mammalian and amphibian cell biology including, cell to cell interactions, cell cycle control, intracellular signaling, differentiation and subcellular organelles.
Active Research Laboratories
- Altman Lab - Circadian Rhythms in Many Organisms
- Ghaemmaghami Lab - Mechanisms of protein folding and degradation within cells
- Gorbunova Lab - Aging, DNA repair, and Cancer
- Lueck Lab - Molecular genetics and experimental treatment of diseases resulting from nonsense mutations
- Mayer-Pröschel Lab - Impairment of Neural Cell Functions During Developmental Insults
- Munger Lab - Mechanisms of Pathogenic Metabolic Manipulation
- Murphy Lab - Dr. Murphy's laboratory uses the zebrafish model, mammalian stem cells, and human cancer cell lines to investigate how epigenetic marks help to drive cell state transitions
- Yao Lab - The understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease
DNA Replication, Repair & Recombination
The fundamental processes DNA undergoes during the cell cycle to both maintain the integrity of the DNA and create genetic diversity.
Active Research Laboratories
- Bi Lab - Chromatin Regulation of Gene Expression in Eukaryotes
- Gorbunova Lab - Aging, DNA repair, and Cancer
- Hayes Lab - Chromatin Structure
- Meyer Lab - Bacterial chromosome re-organization during stress
- Sia Lab - Mutagenesis and Repair of Mitochondrial DNA
Gene Regulation
Processes that cells and viruses use to turn the information in genes into gene products.
Active Research Laboratories
- Altman Lab - Circadian Rhythms in Many Organisms
- Bi Lab - Chromatin Regulation of Gene Expression in Eukaryotes
- Boutz Lab - Understanding the essential roles of RNA processing in normal and tumor cell physiology, and to uncover the molecular mechanisms by which drugs alter gene expression
- Bulger Lab - Chromatin Domains and Enhancer Activation
- Grayhack Lab - The Roles of the Genetic Code in Translation
- Gorbunova Lab - Aging, DNA repair, and Cancer
- Hayes Lab - Chromatin Structure
- Kielkopf Lab - Pre-mRNA Splicing for Treatment of Human Disease
- Mello Lab - Understanding how protein-coding genes and non-coding RNAs (ncRNAs) regulate transcription in pancreatic preneoplastic lesions and gain knowledge of their impact over cellular transformation and tumor initiation
- Meyer Lab - Bacterial chromosome re-organization during stress
- Murphy Lab - Dr. Murphy's laboratory uses the zebrafish model, mammalian stem cells, and human cancer cell lines to investigate how epigenetic marks help to drive cell state transitions.
- O'Connell Lab - Biochemical mechanisms of RNA-mediated gene regulation
- Rossman Lab - The role of metabolism in lineage differentiation
- Steiner Lab - Understanding the molecular mechanisms underlying the development of red blood cells in both normal and disease states
- Wagner Lab - RNA Processing
- Wedekind Lab - Development of New HIV/AIDS Drugs, Antibiotics, & RNA-based Therapeutics
- Yao Lab - The understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease
- Yu Lab - Functions & Mechanisms of RNA Modifications
Molecular Mechanisms in Cell Function and Disease
Investigate the molecular mechanisms that govern cell function and are responsible for pathological processes.
Active Research Laboratories
- Altman Lab - Circadian Rhythms in Many Organisms
- Boutz Lab - Understanding the essential roles of RNA processing in normal and tumor cell physiology, and to uncover the molecular mechanisms by which drugs alter gene expression
- Brookes Lab - Cardiac Ischemia-Reperfusion (IR) Injury and Cardioprotection
- Dickerson Lab - CGRP Signal Transduction
- Ermolenko Lab - Structural Dynamics of Translation
- Ghaemmaghami Lab - Mechanisms of protein folding and degradation within cells
- Gorbunova Lab - Aging, DNA repair, and Cancer
- Kielkopf Lab - Pre-mRNA Splicing for Treatment of Human Disease
- Land Lab - Cooperation of Oncogenic Mutations in the Control of Malignancy
- Lueck Lab - Molecular genetics and experimental treatment of diseases resulting from nonsense mutations
- Maquat Lab - Normal & Disease-Associated RNA Decay
- Mayer-Pröschel Lab - Impairment of Neural Cell Functions During Developmental Insults
- Mello Lab - Understanding how protein-coding genes and non-coding RNAs (ncRNAs) regulate transcription in pancreatic preneoplastic lesions and gain knowledge of their impact over cellular transformation and tumor initiation
- Munger Lab - Mechanisms of Pathogenic Metabolic Manipulation
- Murphy Lab - Dr. Murphy's laboratory uses the zebrafish model, mammalian stem cells, and human cancer cell lines to investigate how epigenetic marks help to drive cell state transitions.
- O'Connell Lab - Biochemical mechanisms of RNA-mediated gene regulation
- Rossman Lab - The role of metabolism in lineage differentiation
- Steiner Lab - Understanding the molecular mechanisms underlying the development of red blood cells in both normal and disease states
- Wagner Lab - RNA Processing
- Yao Lab - The understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease
- Yu Lab - Functions & Mechanisms of RNA Modifications
Protein Structure & Function
Structure and function of proteins from primary to quaternary structures.
Active Research Laboratories
- Hayes Lab - Chromatin Structure
- Kielkopf Lab - Pre-mRNA Splicing for Treatment of Human Disease
- Lueck Lab - Molecular genetics and experimental treatment of diseases resulting from nonsense mutations
- Maquat Lab - Normal & Disease-Associated RNA Decay
- Benjamin Miller Lab - Molecular Recognition & Biosensing
- O'Connell Lab - Biochemical mechanisms of RNA-mediated gene regulation
- Phizicky Lab - tRNA Biogenesis, Function & Quality Control
- Wedekind Lab - Development of New HIV/AIDS Drugs, Antibiotics, & RNA-based Therapeutics
- Yao Lab - The understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease
- Yu Lab - Functions & Mechanisms of RNA Modifications
RNA Structure & Processing
Generation of a mature mRNA (for protein genes) or a functional tRNA or rRNA from the primary transcript.
Active Research Laboratories
- Boutz Lab - Understanding the essential roles of RNA processing in normal and tumor cell physiology, and to uncover the molecular mechanisms by which drugs alter gene expression
- Ermolenko Lab - Structural Dynamics of Translation
- Grayhack Lab - The Roles of the Genetic Code in Translation
- Kielkopf Lab - Pre-mRNA Splicing for Treatment of Human Disease
- Lueck Lab - Molecular genetics and experimental treatment of diseases resulting from nonsense mutations
- Maquat Lab - Normal & Disease-Associated RNA Decay
- Mathews Lab - Computational Biology and Bioinformatics
- Mello Lab - Understanding how protein-coding genes and non-coding RNAs (ncRNAs) regulate transcription in pancreatic preneoplastic lesions and gain knowledge of their impact over cellular transformation and tumor initiation
- Benjamin Miller Lab - Molecular Recognition & Biosensing
- O'Connell Lab - Biochemical mechanisms of RNA-mediated gene regulation
- Phizicky Lab - tRNA Biogenesis, Function & Quality Control
- Wedekind Lab - Development of New HIV/AIDS Drugs, Antibiotics, & RNA-based Therapeutics
- Yao Lab - The understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease
- Yu Lab - Functions & Mechanisms of RNA Modifications
Signal Transduction
Processes by which an extracellular signaling molecule activates a membrane receptor that in turn alters intracellular molecules creating a response.
Active Research Laboratories
- Altman Lab - Circadian Rhythms in Many Organisms
- Dickerson Lab - CGRP Signal Transduction
- Dumont Lab - Signal Transduction; Membrane Protein Structure, Yeast Molecular Biology
- Grossfield Lab - Computer Modeling to Understand Structure and Thermodynamics of Biological Molecules
- Kielkopf Lab - Pre-mRNA Splicing for Treatment of Human Disease
- Land Lab - Cooperation of Oncogenic Mutations in the Control of Malignancy
- Lueck Lab - Molecular genetics and experimental treatment of diseases resulting from nonsense mutations
- Mello Lab - Understanding how protein-coding genes and non-coding RNAs (ncRNAs) regulate transcription in pancreatic preneoplastic lesions and gain knowledge of their impact over cellular transformation and tumor initiation
- Munger Lab - Mechanisms of Pathogenic Metabolic Manipulation
- Yao Lab - The understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease