Center Events

Mohamed EITanbouly, Ph.D. - Postdoctoral Associate, The Rockefeller University

Long lived humoral/antibody immunity is exclusively and directly dependent on the survival of long-lived plasma cells (LLPC). Despite this well-known axion, our understanding of the components driving LLPC generation and maintenance remains largely incomplete. In my postdoctoral studies, I developed a novel genetic fate mapping tool and a surgery system that directly tracks long-lived plasma cells (LLPCs) longitudinally in individual mice for extended time periods. Surprisingly, Long-lived PC (LLPC) of different isotypes (e.g. IgM, IgG, IgA) utilize distinct survival programs, and interactions with accessory cells. These survival programs are primarily hard-wired in the isotype program and appear conserved across tissues/niches. The compartmentalization of survival regulators suggests that LLPC should be studied in an isotype-dependent manner and with a particular focus on the critical genes expressed by and functionally relevant to each LLPC subset. Going forward, we can leverage this framework to aid in optimizing new vaccines that not only skew LLPCs to specific isotypes but maximize their longevity. My future research efforts will continue this line of investigation, with a particular focus on the molecular and metabolic regulators of PC fate and function – both cell-intrinsic and mediated by niche factors.

 Jun 23, 2025 @ 12:00 p.m.
 Medical Center | Adolph Lower Aud. (1-7619)

 Jun 27, 2025 @ 12:00 p.m.