Peer Reviewed & Invited Papers

• Mendelson WB, Martin JV, Perlis ML, Wagner R Sleep and benzodiazepine receptor subtypes. Journal of Neural Transmission, 70:329-336, 1987.
• Mendelson WB, Martin JV, Perlis ML, Wagner R Arousal induced by injection of triazolam into the dorsal raphe nucleus of rats. Neuropsychopharmacology, 1:85 88, 1987.
• Mendelson WB, Martin JV, Perlis ML, Giesen H, Wagner R, Rapport SI Periodic cessation of respiratory effort during sleep in adult rats. Physiology & Behavior, 43:229 234, 1988.
• Mendelson WB, Martin JV, Perlis ML, Wagner R Enhancement of sleep by microinjection of triazolam into the medial preoptic area. Neuropsychopharmacology, 2:61 66, 1989.
• Bootzin RR, Perlis ML Nonpharmacologic treatments of insomnia. Journal of Clinical Psychiatry, 53:37-41, 1992.
• Perlis ML, Nielsen TA Mood regulation, dreaming and nightmares: Evaluation of a desensitization function for REM sleep. Dreaming, 3:243-257, 1993.
• Perlis ML, Giles DE, Fleming G, Drummond P, James S Sustained facial muscle activity during REM sleep in depressed subjects and its correlation with self reported depression. Journal of Affective Disorders, 35:163-171, 1995.
• Buysse DJ, Perlis ML The evaluation and treatment of insomnia. Journal of Practical Psychiatry and Behavioral Health, March; 80-93, 1996.
• Perlis ML, Artiola L, Giles DE The incidence sleep complaints in minor head injured individuals. Perceptual Motor Skills, 84:595-599, 1997.
• Perlis ML, Bootzin RR, Fleming G, Drummond SP, Rose M, Dikman ZV, Giles DE Alpha sleep and information processing, perception of sleep, pain and arousability in fibromyalgia. International Journal of Neuroscience, 89:265-280, 1997.
• Perlis ML, Buysse, D, Giles, DE, Tu X., Kupfer DJ. Sleep disturbance may be a prodromal symptom of depression. Journal of Affective Disorders. 42(2): 209-212, 1997.
• Parsons C, Crosby L, Perlis M, Britt T, Jones P. Longitudinal sleep EEG power spectral analysis studies in adolescents with minor head injured. Journal of Neurotrauma. 14(8) 549-559, 1997.
• Perlis ML, Giles DE, Mendelson WB, Bootzin RR, Wyatt, JK Subjective - objective discrepancies in psychophysiologic insomnia: A neurocognitive perspective. Journal of Sleep Research. 6:179-188, 1997.
• Perlis ML, Buysse DJ, Thase ME, Tu XL, Giles DE, Kupfer DJ Which depressive symptoms relate to which sleep EEG variables. Biological Psychiatry. 42(10):904-913, 1997.
• Giles, D.E., Perlis, M.L., Reynolds, C.F.I., and Kupfer, D.J. EEG Sleep in African-American patients with major depression: A historical case control study. Depression and Anxiety 8(2):58-64, 1998.
• Perlis, M, Aloia M, Boehmler J, Millikan A, Greenblatt D, Giles D. Behavior treatment of insomnia: a clinical case series study. The Journal of Behavioral Medicine,23(2)149-161, 2000.
• Perlis M & Youngsted S. Diagnosis of Primary Insomnia & Treatment Options. Invited Paper to Comprehensive Therapy 26 (4), 298-306, 2000.
• Smith MT, Perlis, ML, Smith, MS, Giles, DE. Sleep Quality in chronic pain. Journal of Behavioral Medicine,23(1), 1-13, 2000.
• Perlis ML, Smith MT, Orff H, Andrews P, Giles, DE. Beta/Gamma activity in patients with insomnia and in good sleeper controls. Sleep,24,(1), 110-117, 2001.
• Smith MT, Perlis, ML, Smith, MS, Giles, DE. Pre-sleep cognitions in patients with insomnia secondary to chronic pain. Journal of Behavioral Medicine,24(1)93-114,2001.
• Stepanski E. & Perlis, M. Behavioral Sleep Medicine: An Emerging Subspecialty in Health Psychology. Journal of Psychosomatic Research,49,343-347, 2000.
• Aloia MS, DiDio L, Ilniczky N, Perlis ML, Greenblatt DW, & Giles DE. Improving compliance with nasal CPAP and vigilance in older adults with OSAHS. Sleep and Breathing, 5(1):13-21, 2001.
• Perlis ML Sharpe MC, Smith MT, Greenblatt DW, Giles DE. Behavioral treatment of insomnia: Treatment outcome and the relevance of medical and psychiatric morbidity. The Journal of Behavioral Medicine 24(3) 281-296. 2001.
• Perlis ML, Kehr EL, Smith MT, Orff H, Andrews P, Giles, DE. Temporal and Stagewise distribution of Beta activity in patients with insomnia and in good sleeper controls. The Journal of Sleep Research, 10, 93-104. 2001.
• Perlis ML, Smith, MT, Orff HJ. Andrews PJ, Giles DE. The mesograde amnesia of sleep may be attenuated in subjects With primary insomnia. Physiology & Behavior,74,71-76. 2001.
• Perlis ML, Merica H, Smith MT, Giles DE. Beta EEG in Insomnia. Invited Paper to Journal of Sleep Medicine Reviews. 5(5) 364-375. 2001.
• Smith MT, Perlis, ML, Park A, Giles DE, Pennington JA, Buysse, D. Behavioral treatment vs pharmacotherapy for Insomnia - A comparative meta-analyses. American Journal of Psychiatry. 159: 5-11. 2002.
• Perlis ML, Smith MT, Orff HJ, Andrews PJ, Giles DE, Gillin, JC. The effects of an orally administered cholinergic agonist on REM sleep in major depression. Biological Psychiatry. 51(6):457-62, 2002.
• Smith, MT, Perlis, ML, Chengazi, VU, Pennington J, Soeffing, J, Ryan JM., Giles, DE. Neuroimaging of NREM sleep in primary insomnia: A preliminary, Tc-99-HMPAO Single Photon Emission Computed Tomography Study. Sleep,25(3) 325-335.2002.
• J. Kowalski, X.M. Tu, G. Jia, M. Perlis, E. Frank, P. Crits-Christoph, D.J. Kupfer. Generalized Covariance-Adjusted Canonical Correlation Analysis with Application to Psychiatry, Statistics in Medicine, Statistics in Medicine, 22: 595-610, 2003.
• Youngsted S, Perlis M, O'Brien P, Palmer M, Smith M. No Association of Sleep with Daily Physical Activity. Journal of Physiology & Behavior,78(3): 395 - 401. 2003.
• Perlis ML, Smith, MT, Cacialli DO. Nowakowski S, Orff HJ. On the comparability of pharmacotherapy and behavior therapy for chronic insomnia - commentary and implications. Journal of Psychosomatic Research, 54 (1): 51-59.2003.
• Aloia MS, DiDio L, Ilniczky N, Perlis ML, Greenblatt DW, & Giles DE. Neuropsychological Changes and Treatment Compliance in Older Adults with Sleep Apnea. Journal of Psychosomatic Research. 54 (1): 71-77.2003.
• Smith MT. Perlis ML. Haythornthwaite JA. Suicidal ideation in outpatients with chronic musculoskeletal pain: an exploratory study of the role of sleep onset insomnia and pain intensity. Clinical Journal of Pain. 20(2):111-8, 2004.
• Drummond SPA, Smith MT, Orff H, Chengazi V & Perlis ML. Functional Imaging Of The Sleeping Brain: Review of Findings and Implications for the Study of Insomnia. In Press. Invited to Sleep Medicine Reviews. 8(3) 227-242, 2004.
• Perlis ML. Smith MT. Orff HJ. Enright T. Nowakowski S. Jungquist C. Plotkin K. The Effects of Modafinil and CBT on Sleep Continuity in Patients with Primary Insomnia. Sleep 27(4) 715-725. 2004.
• Perlis ML, Walsh JK et al. Long-Term Non-nightly administration of zolpidem in the treatment of patients with Primary Insomnia. Journal of Clinical Psychiatry 65(8) 1128-1138. 2004.
• Pandey J, Grandner MA, Crittenden CN, Smith MT, Giles DE, Perlis ML. Meteorological factors and subjective sleep continuity. The International Journal of Biometeorology, 49(3) 152-155. January 2005.
• Smith MT, Perlis ML, Chengazi VU, Soeffing J, McCann U. NREM sleep cerebral blood flow before and after behavior therapy for chronic primary insomnia: preliminary single photon emission computed tomography (SPECT) data Sleep Medicine,6, 93-94. 2005.
• McCall V, Perlis M, Walsh J, Tu, X, Groman A & Krystal A. A Comparison of Placebo and No-Treatment During a Hypnotic Clinical Trial. International Journal of Clinical Pharmacology and Therapeutics 2005; 43: 355-359.
• Perlis M, McCall V, Jungquist J, Pigeon M, Matteson S. Placebo effects in insomnia. Invited to Sleep Medicine Reviews. 9(5):381-9, 2005 Oct.
• Pigeon W, Perlis M. Long term management of insomnia: practical guidelines for physicians. INSOM, 1(5),4-9. 2005.
• Perlis ML, Smith LJ, Lyness J, Matteson S, Pigeon W, Jungquist C, Tu X, Insomnia as a risk factor for depression in the elderly. Journal of Behavioral Sleep Medicine. 4(2) 104-113. 2006.