URMC / Labs / Mosmann Lab / Publications Publications Mosmann TRRebhahn JADe Rosa SCKeefer MCMcElrath MJRouphael NGPantaleo GGilbert PBCorey LKobie JJThakar J SWIFT clustering analysis of intracellular cytokine staining flow cytometry data of the HVTN 105 vaccine trial reveals high frequencies of HIV-specific CD4+ T cell responses and associations with humoral responses.; Frontiers in immunology; Vol 15, pp. 1347926. 2024 Jun 06. Mosmann TRMcMichael AJLeVert AMcCauley JWAlmond JW Opportunities and challenges for T cell-based influenza vaccines.; Nature reviews. Immunology. 2024 May 02. Simpson ELSchlievert PMYoshida TLussier SBoguniewicz MHata TFuxench ZDe Benedetto AOng PYKo JCalatroni ARudman Spergel AKPlaut MQuataert SAKilgore SHPeterson LGill ALDavid GMosmann TGill SRLeung DYMBeck LA Rapid Reduction in Staphylococcus aureus in Atopic Dermatitis Subjects Following Dupilumab Treatment.; The Journal of allergy and clinical immunology. 2023 Jun 12. Moore JEBloom PCChu CCBruno JEHerne CABaran AMQuataert SAMosmann TRTaylor RPWallace DSElliott MRBarr PMZent CS Rituximab induced cytokine release with high serum IP-10 (CXCL10) concentrations is associated with infusion reactions.; Leukemia research; Vol 129, pp. 107072. 2023 Mar 29. Jankovic DCiucci TCoffman RLCoquet JMLe Gros GMosmann TRSher ARonchese F Comment on: Repositioning TH cell polarization from single cytokines to complex help.; Nature immunology. 2022 Feb 21. Rebhahn JAQuataert SASharma GMosmann TR SwiftReg cluster registration automatically reduces flow cytometry data variability including batch effects.; Communications biology; Vol 3(1). 2020 May 07. Tourtelot EQuataert SGlantz JCPerlis LMuthukrishnan GMosmann T Women who received varicella vaccine versus natural infection have different long-term T cell immunity but similar antibody levels.; Vaccine; Vol 38(7). 2020 Feb 11. Cossarizza AChang HDRadbruch AAcs AAdam DAdam-Klages SAgace WWAghaeepour NAkdis MAllez MAlmeida LNAlvisi GAnderson GAndrä IAnnunziato FAnselmo ABacher PBaldari CTBari SBarnaba VBarros-Martins JBattistini LBauer WBaumgart SBaumgarth NBaumjohann DBaying BBebawy MBecher BBeisker WBenes VBeyaert RBlanco ABoardman DABogdan CBorger JGBorsellino GBoulais PEBradford JABrenner DBrinkman RRBrooks AESBusch DHBüscher MBushnell TPCalzetti FCameron GCammarata ICao XCardell SLCasola SCassatella MACavani ACelada AChatenoud LChattopadhyay PKChow SChristakou EČičin-Šain LClerici MColombo FSCook LCooke ACooper AMCorbett AJCosma ACosmi LCoulie PGCumano ACvetkovic LDang VDDang-Heine CDavey MSDavies DDe Biasi SDel Zotto GDela Cruz GVDelacher MDella Bella SDellabona PDeniz GDessing MDi Santo JPDiefenbach ADieli FDolf ADörner TDress RJDudziak DDustin MDutertre CAEbner FEckle SBGEdinger MEede PEhrhardt GRAEich MEngel PEngelhardt BErdei AEsser CEverts BEvrard MFalk CSFehniger TAFelipo-Benavent MFerry HFeuerer MFilby AFilkor KFillatreau SFollo MFörster IFoster JFoulds GAFrehse BFrenette PSFrischbutter SFritzsche WGalbraith DWGangaev AGarbi NGaudilliere BGazzinelli RTGeginat JGerner WGherardin NAGhoreschi KGibellini LGinhoux FGoda KGodfrey DIGoettlinger CGonzález-Navajas JMGoodyear CSGori AGrogan JLGrummitt DGrützkau AHaftmann CHahn JHammad HHämmerling GHansmann LHansson GHarpur CMHartmann SHauser AHauser AEHaviland DLHedley DHernández DCHerrera GHerrmann MHess CHöfer THoffmann PHogquist KHolland THöllt THolmdahl RHombrink PHouston JPHoyer BFHuang BHuang FPHuber JEHuehn JHundemer MHunter CAHwang WYKIannone AIngelfinger FIvison SMJäck HMJani PKJávega BJonjic SKaiser TKalina TKamradt TKaufmann SHEKeller BKetelaars SLCKhalilnezhad AKhan SKisielow JKlenerman PKnopf JKoay HFKobow KKolls JKKong WTKopf MKorn TKriegsmann KKristyanto HKroneis TKrueger AKühne JKukat CKunkel DKunze-Schumacher HKurosaki TKurts CKvistborg PKwok ILandry JLantz OLanuti PLaRosa FLehuen ALeibundGut-Landmann SLeipold MDLeung LYTLevings MKLino ACLiotta FLitwin VLiu YLjunggren HGLohoff MLombardi GLopez LLópez-Botet MLovett-Racke AELubberts ELuche HLudewig BLugli ELunemann SMaecker HTMaggi LMaguire OMair FMair KHMantovani AManz RAMarshall AJMartínez-Romero AMartrus GMarventano IMaslinski WMatarese GMattioli AVMaueröder CMazzoni AMcCluskey JMcGrath MMcGuire HMMcInnes IBMei HEMelchers FMelzer SMielenz DMiller SDMills KHGMinderman HMjösberg JMoore JMoran BMoretta LMosmann TRMüller SMulthoff GMuñoz LEMünz CNakayama TNasi MNeumann KNg LGNiedobitek ANourshargh SNúñez GO'Connor JEOchel AOja AOrdonez DOrfao AOrlowski-Oliver EOuyang WOxenius APalankar RPanse IPattanapanyasat KPaulsen MPavlinic DPenter LPeterson PPeth CPetriz JPiancone FPickl WFPiconese SPinti MPockley AGPodolska MJPoon ZPracht KPrinz IPucillo CEMQuataert SAQuatrini LQuinn KMRadbruch HRadstake TRDJRahmig SRahn HPRajwa BRavichandran GRaz YRebhahn JARecktenwald DReimer DReis E Sousa CRemmerswaal EBMRichter LRico LGRiddell ARieger AMRobinson JPRomagnani CRubartelli ARuland JSaalmüller ASaeys YSaito TSakaguchi SSala-de-Oyanguren FSamstag YSanderson SSandrock ISantoni ASanz RBSaresella MSautes-Fridman CSawitzki BSchadt LScheffold AScherer HUSchiemann MSchildberg FASchimisky ESchlitzer ASchlosser JSchmid SSchmitt SSchober KSchraivogel DSchuh WSchüler TSchulte RSchulz ARSchulz SRScottá CScott-Algara DSester DPShankey TVSilva-Santos BSimon AKSitnik KMSozzani SSpeiser DESpidlen JStahlberg AStall AMStanley NStark RStehle CSteinmetz TStockinger HTakahama YTakeda KTan LTárnok ATiegs GToldi GTornack JTraggiai ETrebak MTree TIMTrotter JTrowsdale JTsoumakidou MUlrich HUrbanczyk Svan de Veen Wvan den Broek Mvan der Pol EVan Gassen SVan Isterdael Gvan Lier RAWVeldhoen MVento-Asturias SVieira PVoehringer DVolk HDvon Borstel Avon Volkmann KWaisman AWalker RVWallace PKWang SAWang XMWard MDWard-Hartstonge KAWarnatz KWarnes GWarth SWaskow CWatson JVWatzl CWegener LWeisenburger TWiedemann AWienands JWilharm AWilkinson RJWillimsky GWing JBWinkelmann RWinkler THWirz OFWong AWurst PYang JHMYang JYazdanbakhsh MYu LYue AZhang HZhao YZiegler SMZielinski CZimmermann JZychlinsky A Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).; European journal of immunology; Vol 49(10). 2019 Oct. Cossarizza AChang HDRadbruch AAndrä IAnnunziato FBacher PBarnaba VBattistini LBauer WMBaumgart SBecher BBeisker WBerek CBlanco ABorsellino GBoulais PEBrinkman RRBüscher MBusch DHBushnell TPCao XCavani AChattopadhyay PKCheng QChow SClerici MCooke ACosma ACosmi LCumano ADang VDDavies DDe Biasi SDel Zotto GDella Bella SDellabona PDeniz GDessing MDiefenbach ADi Santo JDieli FDolf ADonnenberg VSDörner TEhrhardt GRAEndl EEngel PEngelhardt BEsser CEverts BFalk CSFehniger TAFilby AFillatreau SFollo MFörster IFoster JFoulds GAFrenette PSGalbraith DGarbi NGarcía-Godoy MDGhoreschi KGibellini LGoettlinger CGoodyear CSGori AGrogan JGross MGrützkau AGrummitt DHahn JHammer QHauser AEHaviland DLHedley DHerrera GHerrmann MHiepe FHolland THombrink PHouston JPHoyer BFHuang BHunter CAIannone AJäck HMJávega BJonjic SJuelke KJung SKaiser TKalina TKeller BKhan SKienhöfer DKroneis TKunkel DKurts CKvistborg PLannigan JLantz OLarbi ALeibundGut-Landmann SLeipold MDLevings MKLitwin VLiu YLohoff MLombardi GLopez LLovett-Racke ALubberts ELudewig BLugli EMaecker HTMartrus GMatarese GMaueröder CMcGrath MMcInnes IMei HEMelchers FMelzer SMielenz DMills KMjösberg JMoore JMoran BMoretta AMoretta LMosmann TRMüller SMüller WMünz CMulthoff GMunoz LEMurphy KMNakayama TNasi MNeudörfl CNolan JNourshargh SO'Connor JEOuyang WOxenius APalankar RPanse IPeterson PPeth CPetriz JPhilips DPickl WPiconese SPinti MPockley AGPodolska MJPucillo CQuataert SARadstake TRDJRajwa BRebhahn JARecktenwald DRemmerswaal EBMRezvani KRico LGRobinson JPRomagnani CRubartelli ARuland JSakaguchi SSala-de-Oyanguren FSamstag YSanderson SSawitzki BScheffold ASchiemann MSchildberg FSchimisky ESchmid SASchmitt SSchober KSchüler TSchulz ARSchumacher TScotta CShankey TVShemer ASimon AKSpidlen JStall AMStark RStehle CStein MSteinmetz TStockinger HTakahama YTarnok ATian ZToldi GTornack JTraggiai ETrotter JUlrich Hvan der Braber Mvan Lier RAWVeldhoen MVento-Asturias SVieira PVoehringer DVolk HDvon Volkmann KWaisman AWalker RWard MDWarnatz KWarth SWatson JVWatzl CWegener LWiedemann AWienands JWillimsky GWing JWurst PYu LYue AZhang QZhao YZiegler SZimmermann J Guidelines for the use of flow cytometry and cell sorting in immunological studies.; European journal of immunology; Vol 47(10). 2017 Oct. Basha SKaur RMosmann TRPichichero ME Reduced T-Helper 17 Responses to Streptococcus pneumoniae in Infection-Prone Children Can Be Rescued by Addition of Innate Cytokines.; The Journal of infectious diseases; Vol 215(8). 2017 Apr 15. Pedersen NWChandran PAQian YRebhahn JPetersen NVHoff MDWhite SLee AJStanton RHalgreen CJakobsen KMosmann TGouttefangeas CChan CScheuermann RHHadrup SR Automated Analysis of Flow Cytometry Data to Reduce Inter-Lab Variation in the Detection of Major Histocompatibility Complex Multimer-Binding T Cells.; Frontiers in immunology; Vol 8. 2017. Fiorentino DFZlotnik AVieira PMosmann TRHoward MMoore KWO'Garra A Pillars Article: IL-10 Acts on the Antigen-presenting Cell to Inhibit Cytokine Production by Thl Cells. J. Immunol. 1991. 146: 3444-3451.; Journal of immunology (Baltimore, Md. : 1950); Vol 197(5). 2016 Sep 01. Fiorentino DFZlotnik AMosmann TRHoward MO'Garra A Pillars Article: IL-10 Inhibits Cytokine Production by Activated Macrophages. J. Immunol. 1991. 147: 3815-3822.; Journal of immunology (Baltimore, Md. : 1950); Vol 197(5). 2016 Sep 01. Pichichero MECasey JRAlmudevar ABasha SSurendran NKaur RMorris MLivingstone AMMosmann TR Functional Immune Cell Differences Associated With Low Vaccine Responses in Infants.; The Journal of infectious diseases; Vol 213(12). 2016 Jun 15. Finak GLangweiler MJaimes MMalek MTaghiyar JKorin YRaddassi KDevine LObermoser GPekalski MLPontikos NDiaz AHeck SVillanova FTerrazzini NKern FQian YStanton RWang KBrandes ARamey JAghaeepour NMosmann TScheuermann RHReed EPalucka KPascual VBlomberg BBNestle FNussenblatt RBBrinkman RRGottardo RMaecker HMcCoy JP Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium.; Scientific reports; Vol 6. 2016. Brinkman RRAghaeepour NFinak GGottardo RMosmann TScheuermann RH Automated analysis of flow cytometry data comes of age.; Cytometry. Part A : the journal of the International Society for Analytical Cytology; Vol 89(1). 2016 Jan. Aghaeepour NChattopadhyay PChikina MDhaene TVan Gassen SKursa MLambrecht BNMalek MMcLachlan GJQian YQiu PSaeys YStanton RTong DVens CWalkowiak SWang KFinak GGottardo RMosmann TNolan GPScheuermann RHBrinkman RR A benchmark for evaluation of algorithms for identification of cellular correlates of clinical outcomes.; Cytometry. Part A : the journal of the International Society for Analytical Cytology; Vol 89(1). 2016 Jan. Rebhahn JARoumanes DRQi YKhan AThakar JRosenberg ALee FEQuataert SASharma GMosmann TR Competitive SWIFT cluster templates enhance detection of aging changes.; Cytometry. Part A : the journal of the International Society for Analytical Cytology; Vol 89(1). 2016 Jan. Deng NMosmann TR Optimization of the cytokine secretion assay for human IL-2 in single and combination assays.; Cytometry. Part A : the journal of the International Society for Analytical Cytology; Vol 87(8). 2015 Aug. Brinkman RRAghaeepour NFinak GGottardo RMosmann TScheuermann RH State-of-the-Art in the Computational Analysis of Cytometry Data.; Cytometry. Part A : the journal of the International Society for Analytical Cytology; Vol 87(7). 2015 Jul. Kvistborg PGouttefangeas CAghaeepour NCazaly AChattopadhyay PKChan CEckl JFinak GHadrup SRMaecker HTMaurer DMosmann TQiu PScheuermann RHWelters MJFerrari GBrinkman RRBritten CM Thinking outside the gate: single-cell assessments in multiple dimensions.; Immunity; Vol 42(4). 2015 Apr 21. Bobo BPhelan DRebhahn JPiepenbrink MSZheng BMosmann TRKobie JJDeLouise LA Microbubble array diffusion assay for the detection of cell secreted factors.; Lab on a chip; Vol 14(18). 2014 Sep 21. Rebhahn JADeng NSharma GLivingstone AMHuang SMosmann TR An animated landscape representation of CD4+ T-cell differentiation, variability, and plasticity: insights into the behavior of populations versus cells.; European journal of immunology; Vol 44(8). 2014 Aug. Mosmann TRNaim IRebhahn JDatta SCavenaugh JSWeaver JMSharma G SWIFT-scalable clustering for automated identification of rare cell populations in large, high-dimensional flow cytometry datasets, part 2: biological evaluation.; Cytometry. Part A : the journal of the International Society for Analytical Cytology; Vol 85(5). 2014 May. Naim IDatta SRebhahn JCavenaugh JSMosmann TRSharma G SWIFT-scalable clustering for automated identification of rare cell populations in large, high-dimensional flow cytometry datasets, part 1: algorithm design.; Cytometry. Part A : the journal of the International Society for Analytical Cytology; Vol 85(5). 2014 May. Deng NWeaver JMMosmann TR Cytokine diversity in the Th1-dominated human anti-influenza response caused by variable cytokine expression by Th1 cells, and a minor population of uncommitted IL-2+IFNγ- Thpp cells.; PloS one; Vol 9(5). 2014. Miao HSangster MYLivingstone AMHilchey SPZhang LTopham DJMosmann TRHolden-Wiltse JPerelson ASWu HZand MS Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection.; PloS one; Vol 9(8). 2014. Sharma SKRoumanes DAlmudevar AMosmann TRPichichero ME CD4+ T-cell responses among adults and young children in response to Streptococcus pneumoniae and Haemophilus influenzae vaccine candidate protein antigens.; Vaccine; Vol 31(30). 2013 Jun 26. Aghaeepour NFinak GHoos HMosmann TRBrinkman RGottardo RScheuermann RH Critical assessment of automated flow cytometry data analysis techniques.; Nature methods; Vol 10(3). 2013 Mar. Weaver JMYang HRoumanes DLee FEWu HTreanor JJMosmann TR Increase in IFNγ(-)IL-2(+) cells in recent human CD4 T cell responses to 2009 pandemic H1N1 influenza.; PloS one; Vol 8(3). 2013. Moore KWVieira PFiorentino DFTrounstine MLKhan TAMosmann TR Pillars article: homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science. 1990. 248: 1230-1234.; Journal of immunology (Baltimore, Md. : 1950); Vol 189(5). 2012 Sep 1. Li XMiao HHenn ATopham DJWu HZand MSMosmann TR Ki-67 expression reveals strong, transient influenza specific CD4 T cell responses after adult vaccination.; Vaccine; Vol 30(31). 2012 Jun 29. Qi YOperario DJGeoras SNMosmann TR The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin.; PloS one; Vol 7(6). 2012. Wu HKumar AMiao HHolden-Wiltse JMosmann TRLivingstone AMBelz GTPerelson ASZand MSTopham DJ Modeling of influenza-specific CD8+ T cells during the primary response indicates that the spleen is a major source of effectors.; Journal of immunology (Baltimore, Md. : 1950); Vol 187(9). 2011 Nov 1. Mace CRTopham DJMosmann TRQuataert SATreanor JJMiller BL Label-free, arrayed sensing of immune response to influenza antigens.; Talanta; Vol 83(3). 2011 Jan 15. Qi YOperario DJOberholzer CMKobie JJLooney RJGeoras SNMosmann TR Human basophils express amphiregulin in response to T cell-derived IL-3.; The Journal of allergy and clinical immunology; Vol 126(6). 2010 Dec. Miao HHollenbaugh JAZand MSHolden-Wiltse JMosmann TRPerelson ASWu HTopham DJ Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus.; Journal of virology; Vol 84(13). 2010 Jul. Qian YWei CEun-Hyung Lee FCampbell JHalliley JLee JACai JKong YMSadat EThomson EDunn PSeegmiller ACKarandikar NJTipton CMMosmann TSanz IScheuermann RH Elucidation of seventeen human peripheral blood B-cell subsets and quantification of the tetanus response using a density-based method for the automated identification of cell populations in multidimensional flow cytometry data.; Cytometry. Part B, Clinical cytometry; Vol 78 Suppl 1. 2010. Naim IDatta SSharma GCavenaugh JMosmann TR SWIFT: Scalable weighted iterative sampling for flow cytometry clustering.; Proc. IEEE Intl. Conf. Acoustics Speech and Sig. Proc.. 2010 Jan 01. Mosmann TRKobie JJLee FEQuataert SA T helper cytokine patterns: defined subsets, random expression, and external modulation.; Immunologic research; Vol 45(2-3). 2009 Dec. Hilchey SPKobie JJCochran MRSecor-Socha SWang JCHyrien OBurack WRMosmann TRQuataert SABernstein SH Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness.; Journal of immunology (Baltimore, Md. : 1950); Vol 183(10). 2009 Nov 15. Lee HYHawkins EZand MSMosmann TWu HHodgkin PDPerelson AS Interpreting CFSE obtained division histories of B cells in vitro with Smith-Martin and cyton type models.; Bulletin of mathematical biology; Vol 71(7). 2009 Oct. Henn ADRebhahn JBrown MAMurphy AJCoca MNHyrien OPellegrin TMosmann TZand MS Modulation of single-cell IgG secretion frequency and rates in human memory B cells by CpG DNA, CD40L, IL-21, and cell division.; Journal of immunology (Baltimore, Md. : 1950); Vol 183(5). 2009 Sep 1. Friedberg JWKelly JLNeuberg DPeterson DRKutok JLSalloum RBrenn TFisher DCRonan EDalton VRich LMarquis DSims PRothberg PGLiesveld JFisher RICoffman RMosmann TFreedman AS Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma.; British journal of haematology; Vol 146(3). 2009 Aug. Lee HYTopham DJPark SYHollenbaugh JTreanor JMosmann TRJin XWard BMMiao HHolden-Wiltse JPerelson ASZand MWu H Simulation and prediction of the adaptive immune response to influenza A virus infection.; Journal of virology; Vol 83(14). 2009 Jul. Hilchey SPHyrien OMosmann TRLivingstone AMFriedberg JWYoung FFisher RIKelleher RJBankert RBBernstein SH Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab.; Blood; Vol 113(16). 2009 Apr 16. Seavey MMMosmann TR Estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming in response to intravaginal immunization.; Vaccine; Vol 27(17). 2009 Apr 14. Wang JCKobie JJZhang LCochran MMosmann TRRitchlin CTQuataert SA An 11-color flow cytometric assay for identifying, phenotyping, and assessing endocytic ability of peripheral blood dendritic cell subsets in a single platform.; Journal of immunological methods; Vol 341(1-2). 2009 Feb 28. Rebhahn JABishop CDivekar AAJiminez-Garcia KKobie JJLee FEMaupin GMSnyder-Cappione JEZaiss DMMosmann TR Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion.; Computer methods and programs in biomedicine; Vol 92(1). 2008 Oct. Zaiss DMSijts AJMosmann TR Enumeration of cytotoxic CD8 T cells ex vivo during the response to Listeria monocytogenes infection.; Infection and immunity; Vol 76(10). 2008 Oct.