The impact of p53 loss and Kras mutation on coding and non-coding genes associated with pancreatic cancer development

Pancreatic cancer is a deadly disease with a less than 5-year survival rate. In pancreatic ductal adenocarcinoma (PDAC), an activating mutation in the Kras proto-oncogene drives the formation preneoplastic lesions named pancreatic intraepithelial neoplasias (PanINs). Subsequently, the progression from PanINs to metastatic PDAC is linked to the loss of p53. We are studying the impact of early mutations in the biology of pancreatic cells, aiming to identify key steps involved in tumor initiation.

 

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