URMC / Labs / Mello Lab / Publications Publications Cazarin JDeRollo REShahidan SNABABurchett JBMwangi DKrishnaiah SHsieh ALWalton ZEBrooks RMello SSWeljie AMDang CVAltman BJ MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis.; PLoS genetics; Vol 19(8), pp. e1010904. 2023 Aug 28. Liu XBurke RMLighthouse JKBaker CDDirkx RAKang BChakraborty YMickelsen DMTwardowski JMello SSAshton JMSmall EM P53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricle Pressure Overload.; Circulation research. 2023 Jul 06. Mello SSFlowers BMMazur PKLee JJMüller FDenny SKFerreira SHanson KKim SKGreenleaf WJWood LDAttardi LD Multifaceted role for p53 in pancreatic cancer suppression.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(10), pp. e2211937120. 2023 Feb 27. DeRollo RECazarin JAhmad Shahidan SNABBurchett JBMwangi DKrishnaiah SHsieh ALWalton ZEBrooks RMello SSWeljie AMDang CVAltman BJ MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis.; bioRxiv : the preprint server for biology. 2023 Jan 04. Guo BFriedland SCAlexander WMyers JAWang WO'Dell MRGetman MWhitney-Miller CLAgostini-Vulaj DHuber ARMello SSVertino PMLand HKSteiner LAHezel AF Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma.; Cell reports; Vol 40(9), pp. 111253. 2022 Aug 30. Moon EJMello SSLi CGChi JTThakkar KKirkland JGLagory ELLee IJDiep ANMiao YRafat MVilalta MCastellini LKrieg AJGraves EEAttardi LDGiaccia AJ The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling.; Nature communications; Vol 12(1), pp. 4308. 2021 Jul 14. Bieging-Rolett KTKaiser AMMorgens DWBoutelle AMSeoane JAVan Nostrand ELZhu CHoulihan SLMello SSYee BAMcClendon JPierce SEWinters IPWang MConnolly AJLowe SWCurtis CYeo GWWinslow MMBassik MCAttardi LD Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.; Molecular cell; Vol 80(3). 2020 Nov 05. Valente LJTarangelo ALi AMNaciri MRaj NBoutelle AMLi YMello SSBieging-Rolett KDeBerardinis RJYe JDixon SJAttardi LD p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen.; The Journal of cell biology; Vol 219(11). 2020 Nov 02. Huang JSachdeva MXu ERobinson TJLuo LMa YWilliams NTLopez OCervia LDYuan FQin XZhang DOwzar KGokgoz NSeto AOkada TSinger SAndrulis ILWunder JSLazar AJRubin BPPipho KMello SSGiudice JKirsch DG The Long Noncoding RNA NEAT1 Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways.; Molecular cancer research : MCR; Vol 18(10). 2020 Oct. Mello SBohmann D Counting the Minutes.; eLife; Vol 9. 2020 Jan 07. Mello SSAttardi LD Deciphering p53 signaling in tumor suppression.; Current opinion in cell biology; Vol 51. 2018 Apr. Chernikova SBNguyen RBTruong JTMello SSStafford JHHay MPOlson ASolow-Cordero DEWood DJHenry Svon Eyben RDeng LGephart MHAroumougame AWiese CGame JCGyőrffy BBrown JM Dynamin impacts homology-directed repair and breast cancer response to chemotherapy.; The Journal of clinical investigation; Vol 128(12). 2018 Jan 03. Mello SSAttardi LD Neat-en-ing up our understanding of p53 pathways in tumor suppression.; Cell cycle (Georgetown, Tex.); Vol 17(13). 2018. Mello SSSinow CRaj NMazur PKBieging-Rolett KBroz DKImam JFCVogel HWood LDSage JHirose TNakagawa SRinn JAttardi LD Neat1 is a p53-inducible lincRNA essential for transformation suppression.; Genes & development; Vol 31(11). 2017 Jun 01. Mello SSValente LJRaj NSeoane JAFlowers BMMcClendon JBieging-Rolett KTLee JIvanochko DKozak MMChang DTLongacre TAKoong ACArrowsmith CHKim SKVogel HWood LDHruban RHCurtis CAttardi LD A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer.; Cancer cell; Vol 32(4). 2017 Jan 09. Mazur PKHerner AMello SSWirth MHausmann SSánchez-Rivera FJLofgren SMKuschma THahn SAVangala DTrajkovic-Arsic MGupta AHeid INoël PBBraren RErkan MKleeff JSipos BSayles LCHeikenwalder MHeßmann EEllenrieder VEsposito IJacks TBradner JEKhatri PSweet-Cordero EAAttardi LDSchmid RMSchneider GSage JSiveke JT Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.; Nature medicine; Vol 21(10). 2015 Oct. Van Nostrand JLBrisac AMello SSJacobs SBLuong RAttardi LD The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.; Cancer discovery; Vol 5(6). 2015 Jun. Bieging KTMello SSAttardi LD Unravelling mechanisms of p53-mediated tumour suppression.; Nature reviews. Cancer; Vol 14(5). 2014 May. Brady CAJiang DMello SSJohnson TMJarvis LAKozak MMKenzelmann Broz DBasak SPark EJMcLaughlin MEKarnezis ANAttardi LD Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression.; Cell; Vol 145(4). 2011 May 13. Mello SSFachin ALJunta CMSandrin-Garcia PDonadi EAPassos GASakamoto-Hojo ET Delayed effects of exposure to a moderate radiation dose on transcription profiles in human primary fibroblasts.; Environmental and molecular mutagenesis; Vol 52(2). 2011 Mar. Gitaí DLFachin ALMello SSElias CFBittencourt JCLeite JPPassos GAGarcia-Cairasco NPaçó-Larson ML The non-coding RNA BC1 is down-regulated in the hippocampus of Wistar Audiogenic Rat (WAR) strain after audiogenic kindling.; Brain research; Vol 1367. 2011 Jan 07. Carminati POMello SSFachin ALJunta CMSandrin-Garcia PCarlotti CGDonadi EAPassos GASakamoto-Hojo ET Alterations in gene expression profiles correlated with cisplatin cytotoxicity in the glioma U343 cell line.; Genetics and molecular biology; Vol 33(1). 2010 Jan. Sandrin-Garcia PJunta CMFachin ALMello SSBaião AMRassi DMFerreira MCTrevisan GLSakamoto-Hojo ETLouzada-Júnior PPassos GADonadi EA Shared and unique gene expression in systemic lupus erythematosus depending on disease activity.; Annals of the New York Academy of Sciences; Vol 1173. 2009 Sep. Junta CMSandrin-Garcia PFachin-Saltoratto ALMello SSOliveira RDRassi DMGiuliatti SSakamoto-Hojo ETLouzada-Junior PDonadi EAPassos GA Differential gene expression of peripheral blood mononuclear cells from rheumatoid arthritis patients may discriminate immunogenetic, pathogenic and treatment features.; Immunology; Vol 127(3). 2009 Jul. Zárate-Bladés CRBonato VLda Silveira ELOliveira e Paula MJunta CMSandrin-Garcia PFachin ALMello SSCardoso RSGaletti FCCoelho-Castelo AARamos SGDonadi EASakamoto-Hojo ETPassos GASilva CL Comprehensive gene expression profiling in lungs of mice infected with Mycobacterium tuberculosis following DNAhsp65 immunotherapy.; The journal of gene medicine; Vol 11(1). 2009 Jan. Fachin ALMello SSSandrin-Garcia PJunta CMGhilardi-Netto TDonadi EAPassos GASakamoto-Hojo ET Gene expression profiles in radiation workers occupationally exposed to ionizing radiation.; Journal of radiation research; Vol 50(1). 2009 Jan. Rassi DMJunta CMFachin ALSandrin-Garcia PMello SSilva GLEvangelista AFMagalhães DAWastowski IJCrispim JOMartelli-Palomino GFernandes APDeghaide NNFoss-Freitas MCFoss MCSoares CPSakamoto-Hojo ETPassos GADonadi EA Gene expression profiles stratified according to type 1 diabetes mellitus susceptibility regions.; Annals of the New York Academy of Sciences; Vol 1150. 2008 Dec. Fachin ALMello SSSandrin-Garcia PJunta CMDonadi EAPassos GASakamoto-Hojo ET Gene expression profiles in human lymphocytes irradiated in vitro with low doses of gamma rays.; Radiation research; Vol 168(6). 2007 Dec. Baião AMWowk PFSandrin-Garcia PJunta CMFachin ALMello SSSakamoto-Hojo ETDonadi EAPassos GA cDNA microarray analysis of cyclosporin A (CsA)-treated human peripheral blood mononuclear cells reveal modulation of genes associated with apoptosis, cell-cycle regulation and DNA repair.; Molecular and cellular biochemistry; Vol 304(1-2). 2007 Oct. Silva GLJunta CMMello SSGarcia PSRassi DMSakamoto-Hojo ETDonadi EAPassos GA Profiling meta-analysis reveals primarily gene coexpression concordance between systemic lupus erythematosus and rheumatoid arthritis.; Annals of the New York Academy of Sciences; Vol 1110. 2007 Sep. Rassi DMJunta CMFachin ALSandrin-Garcia PMello SSFernandes APDeghaide NNFoss-Freitas MCFoss MCSakamoto-Hojo ETPassos GADonadi EA Is HLA class II profile relevant for the study of large-scale differentially expressed genes in type 1 diabetes mellitus patients?; Annals of the New York Academy of Sciences; Vol 1079. 2006 Oct. Trevisan GLRassi DMBaião AMSandrin-Garcia PMello SSTamia-Ferreira MCJunta CMFachin ALMarques MMSakamoto-Hojo ETDonadi EAPassos GA Using cDNA microarrays to identify human CD19(+) B cell gene products (ESTs) originated from systemic lupus erythematosus susceptibility loci.; Autoimmunity reviews; Vol 5(5). 2006 May. Cardoso RSJunta CMMacedo CMagalhães DASilveira ELPaula MOMarques MMMello SSZárate-Bladés CRNguyen CHoulgatte RDonadi EASakamoto-Hojo ETPassos GA Hybridization signatures of gamma-irradiated murine fetal thymus organ culture (FTOC) reveal modulation of genes associated with T-cell receptor V(D)J recombination and DNA repair.; Molecular immunology; Vol 43(5). 2006 Feb. Marques MMJunta CMCardoso RSMello SSSakamoto-Hojo ETDonadi EAPassos GA Changes in the gene expression profiling of the thymus in response to fibrosarcoma growth.; Molecular and cellular biochemistry; Vol 276(1-2). 2005 Aug. Magalhães DAMacedo CJunta CMMello SSMarques MMCardoso RSSakamoto-Hojo ETDonadi EAPassos GA Hybridization signatures during thymus ontogeny reveals modulation of genes coding for T-cell signaling proteins.; Molecular immunology; Vol 42(9). 2005 May. Pereira ETamia-Ferreira MCCardoso RSMello SSSakamoto-Hojo ETPassos GADonadi EA Immunosuppressive therapy modulates T lymphocyte gene expression in patients with systemic lupus erythematosus.; Immunology; Vol 113(1). 2004 Sep. Sakamoto-Hojo ETMello SSPereira EFachin ALCardoso RSJunta CMSandrin-Garcia PDonadi EAPassos GA Gene expression profiles in human cells submitted to genotoxic stress.; Mutation research; Vol 544(2-3). 2003 Nov. Peitl PMello SSCamparoto MLPassos GAHande MPCardoso RSSakamoto-Hojo ET Chromosomal rearrangements involving telomeric DNA sequences in Balb/3T3 cells transfected with the Ha-ras oncogene.; Mutagenesis; Vol 17(1). 2002 Jan.