Welcome to the Lueck Lab
The Lueck lab focuses on the molecular genetics and experimental treatment of diseases resulting from nonsense mutations. They are investigating the use of engineered tRNAs for suppression of nonsense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) transcripts as therapeutic intervention for cystic fibrosis. Additionally, we am interested in the molecular genetics and experimental treatment of the trinucleotide repeat disorder myotonic dystrophy (DM1). Moving forward, we intend to study pre-mRNA splicing defects in DM1 to determine the causes of muscle weakness and wasting, and develop and test new therapeutic strategies to target the genetic misstep and reverse symptoms. More broadly, the lab is interested in applying membrane biophysics, molecular and cellular biology approaches to understand the molecular underpinning of genetic diseases and develop therapeutic interventions.
Attention Graduate Students, Undergraduate Students, Postdocs
We are looking for highly motivated individuals who are interested in conducting research in the area of RNA biology and their use as therapeutics and skeletal muscle ion channel biophysics. Please contact Professor Lueck and visit our working in the lab page for more details.