Flaum Eye Institute / Research / Labs / Libby Lab / Publications Recent Publications Diemler CAMacLean MHeuer SEHewes AAMarola OJLibby RTHowell GR Microglia depletion leads to increased susceptibility to ocular hypertension-dependent glaucoma.; Frontiers in aging neuroscience; Vol 16, pp. 1396443. 2024 Jul 02. Andersh KMMacLean MHowell GRLibby RT IL1A enhances TNF-induced retinal ganglion cell death.; bioRxiv : the preprint server for biology. 2024 Jun 01. McKee CFoley KAndersh KMMarola OJWadzinski BLibby RTShrager PXia H Neuronal protein phosphatase 1β regulates glutamate release, cortical myelination, node of Ranvier formation, and action potential propagation in the optic nerve.; bioRxiv : the preprint server for biology. 2024 May 10. Diemler CAMacLean MHeuer SEHewes AAMarola OJLibby RTHowell GR Microglia Depletion leads to Increased Susceptibility to Ocular Hypertension-Dependent Glaucoma.; bioRxiv : the preprint server for biology. 2024 Mar 10. Maes MEDonahue RJSchlamp CLMarola OJLibby RTNickells RW BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps.; Molecular neurodegeneration; Vol 18(1), pp. 67. 2023 Sep 26. Wang XDelle CPeng WPlá VGiannetto MKusk PSigurdsson BSakurai SSweeney ASun QDu TLibby RTNedergaard M Age- and glaucoma-induced changes to the ocular glymphatic system.; Neurobiology of disease. 2023 Jan 11. Wang VHeffer ARoztocil EFeldon SELibby RTWoeller CFKuriyan AE TNF-α and NF-κB signaling play a critical role in cigarette smoke-induced epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy.; PloS one; Vol 17(9), pp. e0271950. 2022 Sep 01. Marola OJYablonski SERShrager PGNickells RWLibby RT BclXL (Bcl2l1) gene therapy lessens retinal ganglion cell soma loss but not axonal degeneration after acute axonal injury.; Cell death discovery; Vol 8(1), pp. 331. 2022 Jul 22. Marola OJHowell GRLibby RT Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death.; Cell death discovery; Vol 8(1). 2022 Apr 16. Syc-Mazurek SBYang HSMarola OJHowell GRLibby RT Transcriptional control of retinal ganglion cell death after axonal injury.; Cell death & disease; Vol 13(3). 2022 Mar 16. Marola OJSyc-Mazurek SBHowell GRLibby RT Endothelin 1-induced retinal ganglion cell death is largely mediated by JUN activation.; Cell death & disease; Vol 11(9). 2020 Sep 26. Heffer AWang VSridhar JFeldon SELibby RTWoeller CFKuriyan AE A Mouse Model of Proliferative Vitreoretinopathy Induced by Intravitreal Injection of Gas and RPE Cells.; Translational vision science & technology; Vol 9(7). 2020 Jun. Wang XLou NEberhardt AYang YKusk PXu QFörstera BPeng SShi MLadrón-de-Guevara ADelle CSigurdsson BXavier ALRErtürk ALibby RTChen LThrane ASNedergaard M An ocular glymphatic clearance system removes β-amyloid from the rodent eye.; Science translational medicine; Vol 12(536). 2020 Mar 25. Heffer AMWang VLibby RTFeldon SEWoeller CFKuriyan AE Salinomycin inhibits proliferative vitreoretinopathy formation in a mouse model.; PloS one; Vol 15(12). 2020. Yoon CQi YMestre HCanavesi CMarola OJCogliati ANedergaard MLibby RTRolland JP Gabor domain optical coherence microscopy combined with laser scanning confocal fluorescence microscopy.; Biomedical optics express; Vol 10(12). 2019 Dec 01. Syc-Mazurek SBLibby RT Axon injury signaling and compartmentalized injury response in glaucoma.; Progress in retinal and eye research. 2019 Jul 10. Marola OJSyc-Mazurek SBLibby RT DDIT3 (CHOP) contributes to retinal ganglion cell somal loss but not axonal degeneration in DBA/2J mice.; Cell death discovery; Vol 5. 2019. Heffer AMProaño JRoztocil EPhipps RPFeldon SEHuxlin KRSime PJLibby RTWoeller CFKuriyan AE The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology.; PloS one; Vol 14(9). 2019. Harder JMWilliams PASoto IFoxworth NEFernandes KAFreeburg NFLibby RTJohn SWM Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice.; Cell death & disease; Vol 9(6). 2018 Jun 13. Fahrenthold BKFernandes KALibby RT Assessment of intrinsic and extrinsic signaling pathway in excitotoxic retinal ganglion cell death.; Scientific reports; Vol 8(1). 2018 Mar 15. Fernandes KAMitchell KLPatel AMarola OJShrager PZack DJLibby RTWelsbie DS Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury.; Experimental eye research. 2018 Mar 08. Rausch RLLibby RTKiernan AE Trabecular meshwork morphogenesis: A comparative analysis of wildtype and anterior segment dysgenesis mouse models.; Experimental eye research. 2018 Feb 13. Syc-Mazurek SBRausch RLFernandes KAWilson MPLibby RT Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death.; Cell death & disease; Vol 9(11). 2018 Jan 26. Rausch RLLibby RTKiernan AE Ciliary margin-derived BMP4 does not have a major role in ocular development.; PloS one; Vol 13(5). 2018. Syc-Mazurek SBFernandes KAWilson MPShrager PLibby RT Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury.; Molecular neurodegeneration; Vol 12(1). 2017 Oct 02. Apara AGalvao JWang YBlackmore MTrillo AIwao KBrown DPFernandes KAHuang ANguyen TAshouri MZhang XShaw PXKunzevitzky NJMoore DLLibby RTGoldberg JL KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS.; The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017 Sep 04. Syc-Mazurek SBFernandes KALibby RT JUN is important for ocular hypertension-induced retinal ganglion cell degeneration.; Cell death & disease; Vol 8(7). 2017 Jul 20. Harder JMBraine CEWilliams PAZhu XMacNicoll KHSousa GLBuchanan RASmith RSLibby RTHowell GRJohn SWM Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective.; Proceedings of the National Academy of Sciences of the United States of America. 2017 Apr 26. Majumder SZhu GXu XSenchanthisai SJiang DLiu HXue CWang XCoia HCui ZSmolock EMLibby RTBerk BCPang J G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling.; Cell reports; Vol 17(10). 2016 Dec 06. Fernandes KABloomsburg SJMiller CJBillingslea SAMerrill MMBurgess RWLibby RTFuerst PG Novel axon projection after stress and degeneration in the Dscam mutant retina.; Molecular and cellular neurosciences; Vol 71. 2016 Mar. Levin LACrowe MEQuigley HA Neuroprotection for glaucoma: Requirements for clinical translation.; Experimental eye research; Vol 157, pp. 34-37. 2016 Jan 09. Alavi MVMao MPawlikowski BTKvezereli MDuncan JLLibby RTJohn SWGould DB Col4a1 mutations cause progressive retinal neovascular defects and retinopathy.; Scientific reports; Vol 6. 2016. Fernandes KAHarder JMWilliams PARausch RLKiernan AENair KSAnderson MGJohn SWHowell GRLibby RT Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.; Experimental eye research; Vol 141. 2015 Dec. Hedberg-Buenz AChristopher MALewis CJFernandes KADutca LMWang KScheetz TEAbràmoff MDLibby RTGarvin MKAnderson MG Quantitative measurement of retinal ganglion cell populations via histology-based random forest classification.; Experimental eye research. 2015 Oct 22. Mao MSmith RSAlavi MVMarchant JKCosma MLibby RTJohn SWGould DB Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma in Col4a1 Mutant Mice.; Investigative ophthalmology & visual science; Vol 56(11). 2015 Oct. Fernandes KAHarder JMJohn SWShrager PLibby RT DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury.; Neurobiology of disease; Vol 69. 2014 Sep. Coleman JAZhu XDjajadi HRMolday LLSmith RSLibby RTJohn SWMolday RS Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival.; Journal of cell science; Vol 127(Pt 5). 2014 Mar 1. Strazzeri JMHunter JJMasella BDYin LFischer WSDiLoreto DALibby RTWilliams DRMerigan WH Focal damage to macaque photoreceptors produces persistent visual loss.; Experimental eye research; Vol 119. 2014 Feb. Soto IHowell GRJohn CWKief JLLibby RTJohn SW DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation.; PloS one; Vol 9(9). 2014. Mac Nair CEFernandes KASchlamp CLLibby RTNickells RW Tumor necrosis factor alpha has an early protective effect on retinal ganglion cells after optic nerve crush.; Journal of neuroinflammation; Vol 11. 2014. Huang LHu FXie XHarder JFernandes KZeng XYLibby RGan L Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice.; PloS one; Vol 9(4). 2014. Howell GRSoto ILibby RTJohn SW Intrinsic axonal degeneration pathways are critical for glaucomatous damage.; Experimental neurology; Vol 246. 2013 Aug. Fernandes KAHarder JMKim JLibby RT JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells.; Experimental eye research; Vol 112. 2013 Jul. Jiang YDing QXie XLibby RTLefebvre VGan L Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells.; The Journal of biological chemistry; Vol 288(25). 2013 Jun 21. Howell GRLibby RT Adding metabolomics to the toolbox for studying retinal disease.; Investigative ophthalmology & visual science; Vol 54(6). 2013 Jun. Zhou YTanzie CYan ZChen SDuncan MGaudenz KLi HSeidel CLewis BMoran ALibby RTKiernan AEXie T Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye.; Proceedings of the National Academy of Sciences of the United States of America; Vol 110(22). 2013 May 28. Harder JMLibby RT Deficiency in Bim, Bid and Bbc3 (Puma) do not prevent axonal injury induced death.; Cell death and differentiation; Vol 20(1). 2013 Jan. Harder JMDing QFernandes KACherry JDGan LLibby RT BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cells.; Molecular and cellular neurosciences; Vol 51(1-2). 2012 Aug. Fernandes KAHarder JMFornarola LBFreeman RSClark AFPang IHJohn SWLibby RT JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death.; Neurobiology of disease; Vol 46(2). 2012 May. Geng YDubra AYin LMerigan WHSharma RLibby RTWilliams DR Adaptive optics retinal imaging in the living mouse eye.; Biomedical optics express; Vol 3(4). 2012 Apr 1. Howell GRSoto IZhu XRyan MMacalinao DGSousa GLCaddle LBMacNicoll KHBarbay JMPorciatti VAnderson MGSmith RSClark AFLibby RTJohn SW Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma.; The Journal of clinical investigation; Vol 122(4). 2012 Apr. Zhu XLibby RTde Vries WNSmith RSWright DLBronson RTSeburn KLJohn SW Mutations in a P-type ATPase gene cause axonal degeneration.; PLoS genetics; Vol 8(8). 2012. Harder JMFernandes KALibby RT The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice.; Scientific reports; Vol 2. 2012. Lopes VSGibbs DLibby RTAleman TSWelch DLLillo CJacobson SGRadu RASteel KPWilliams DS The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65.; Human molecular genetics; Vol 20(13). 2011 Jul 1. Xi XMcMillan DHLehmann GMSime PJLibby RTHuxlin KRFeldon SEPhipps RP Ocular fibroblast diversity: implications for inflammation and ocular wound healing.; Investigative ophthalmology & visual science; Vol 52(7). 2011 Jun. Howell GRMacalinao DGSousa GLWalden MSoto IKneeland SCBarbay JMKing BLMarchant JKHibbs MStevens BBarres BAClark AFLibby RTJohn SW Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma.; The Journal of clinical investigation; Vol 121(4). 2011 Apr. Yin LGreenberg KHunter JJDalkara DKolstad KDMasella BDWolfe RVisel MStone DLibby RTDiloreto DSchaffer DFlannery JWilliams DRMerigan WH Intravitreal injection of AAV2 transduces macaque inner retina.; Investigative ophthalmology & visual science; Vol 52(5). 2011 Apr. Geng YSchery LASharma RDubra AAhmad KLibby RTWilliams DR Optical properties of the mouse eye.; Biomedical optics express; Vol 2(4). 2011. Harder JMLibby RT BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina.; Molecular neurodegeneration; Vol 6. 2011. Howell GRWalton DOKing BLLibby RTJohn SW Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data.; BMC genomics; Vol 12. 2011. Libby RTGould DB Endoplasmic reticulum stress as a primary pathogenic mechanism leading to age-related macular degeneration.; Advances in experimental medicine and biology; Vol 664. 2010. Feng LXie ZHDing QXie XLibby RTGan L MATH5 controls the acquisition of multiple retinal cell fates.; Molecular brain; Vol 3. 2010. Bertram KMBaglole CJPhipps RPLibby RT Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration.; American journal of physiology. Cell physiology; Vol 297(5). 2009 Nov. Scoles DGray DCHunter JJWolfe RGee BPGeng YMasella BDLibby RTRussell SWilliams DRMerigan WH In-vivo imaging of retinal nerve fiber layer vasculature: imaging histology comparison.; BMC ophthalmology; Vol 9. 2009 Aug 23. Ding QChen HXie XLibby RTTian NGan L BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 29(13). 2009 Apr 1. Howell GRLibby RTJohn SW Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection.; Progress in brain research; Vol 173. 2008. Howell GRLibby RTJakobs TCSmith RSPhalan FCBarter JWBarbay JMMarchant JKMahesh NPorciatti VWhitmore AVMasland RHJohn SW Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma.; The Journal of cell biology; Vol 179(7). 2007 Dec 31. Howell GRLibby RTMarchant JKWilson LACosma IMSmith RSAnderson MGJohn SW Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1.; BMC genetics; Vol 8. 2007. Libby RTHowell GRPang IHSavinova OVMehalow AKBarter JWSmith RSClark AFJohn SW Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model.; BMC neuroscience; Vol 8. 2007. Anderson MGLibby RTMao MCosma IMWilson LASmith RSJohn SW Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma.; BMC biology; Vol 4. 2006. Whitmore AVLibby RTJohn SW Glaucoma: thinking in new ways-a rôle for autonomous axonal self-destruction and other compartmentalised processes?; Progress in retinal and eye research; Vol 24(6). 2005 Nov. Jakobs TCLibby RTBen YJohn SWMasland RH Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice.; The Journal of cell biology; Vol 171(2). 2005 Oct 24. Libby RTAnderson MGPang IHRobinson ZHSavinova OVCosma IMSnow AWilson LASmith RSClark AFJohn SW Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration.; Visual neuroscience; Vol 22(5). 2005 Sep. Kitamoto JLibby RTGibbs DSteel KPWilliams DS Myosin VI is required for normal retinal function.; Experimental eye research; Vol 81(1). 2005 Jul. Libby RTLi YSavinova OVBarter JSmith RSNickells RWJohn SW Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage.; PLoS genetics; Vol 1(1). 2005 Jul. Anderson MGLibby RTGould DBSmith RSJohn SW High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma.; Proceedings of the National Academy of Sciences of the United States of America; Vol 102(12). 2005 Mar 22. Libby RTGould DBAnderson MGJohn SW Complex genetics of glaucoma susceptibility.; Annual review of genomics and human genetics; Vol 6. 2005. Gibbs DAzarian SMLillo CKitamoto JKlomp AESteel KPLibby RTWilliams DS Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes.; Journal of cell science; Vol 117(Pt 26). 2004 Dec 15. Libby RTLillo CKitamoto JWilliams DSSteel KP Myosin Va is required for normal photoreceptor synaptic activity.; Journal of cell science; Vol 117(Pt 19). 2004 Sep 1. Libby RTKitamoto JHolme RHWilliams DSSteel KP Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration.; Experimental eye research; Vol 77(6). 2003 Dec. Libby RTSmith RSSavinova OVZabaleta AMartin JEGonzalez FJJohn SW Modification of ocular defects in mouse developmental glaucoma models by tyrosinase.; Science (New York, N.Y.); Vol 299(5612). 2003 Mar 7. Warner CLStewart ALuzio JPSteel KPLibby RTKendrick-Jones JBuss F Loss of myosin VI reduces secretion and the size of the Golgi in fibroblasts from Snell's waltzer mice.; The EMBO journal; Vol 22(3). 2003 Feb 3. Kros CJMarcotti Wvan Netten SMSelf TJLibby RTBrown SDRichardson GPSteel KP Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations.; Nature neuroscience; Vol 5(1). 2002 Jan. Libby RTSteel KP Electroretinographic anomalies in mice with mutations in Myo7a, the gene involved in human Usher syndrome type 1B.; Investigative ophthalmology & visual science; Vol 42(3). 2001 Mar. Libby RTChampliaud MFClaudepierre TXu YGibbons EPKoch MBurgeson REHunter DDBrunken WJ Laminin expression in adult and developing retinae: evidence of two novel CNS laminins.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 20(17). 2000 Sep 1. Libby RTSteel KP The roles of unconventional myosins in hearing and deafness.; Essays in biochemistry; Vol 35. 2000. Libby RTBrunken WJHunter DD Roles of the extracellular matrix in retinal development and maintenance.; Results and problems in cell differentiation; Vol 31. 2000. Libby RTLavallee CRBalkema GWBrunken WJHunter DD Disruption of laminin beta2 chain production causes alterations in morphology and function in the CNS.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 19(21). 1999 Nov 1. Libby RTXu YSelfors LMBrunken WJHunter DD Identification of the cellular source of laminin beta2 in adult and developing vertebrate retinae.; The Journal of comparative neurology; Vol 389(4). 1997 Dec 29. Libby RTHunter DDBrunken WJ Developmental expression of laminin beta 2 in rat retina. Further support for a role in rod morphogenesis.; Investigative ophthalmology & visual science; Vol 37(8). 1996 Jul.