Faculty
Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.
Role of Type 3 Interferon in the Pathophysiology of Systemic Lupus
Nanomaterial and microplastic toxicology focused on the skin; develop novel microphysiologic tissue chips for drug discovery and toxicity testing; investigate environmental pollutants in autoimmune disease.
Understanding the interaction of HIV with glial cells; Developing an improved live attenuated influenza vaccine (LAIV); Elucidating the host cell response to infection by viral pathogens (with emphasis on SARS-CoV-2 and Adeno-associated virus, AAV)
Translational women’s health research; To identify previously unknown mechanisms of disease for disabling vulvar conditions, namely vulvodynia and lichens
Defining molecular pathways by which inhaled allergens and particulates activate lung mucosal immunity.
Effect of lifestyle, human milk, and infant microbiome of development of immune system and allergic diseases.
Cancer immunotherapy/Host immune response to influenza infection/ Inflammation biology of sepsis
Defining the impact of environmental exposures on immune system development and function, with emphasis on how early life exposures shape health and disease later in life.
Translational cancer research and immunotherapy
Glia-neuron interactions during synaptic plasticity in health and disease.
Developing methods to: model microRNA-seq data, analyze confocal microscopy images of microglia, and estimate gene regulatory networks from perturbation experiments.
In vitro models of human lung and vascular barriers during inflammation.
Carbohydrate and protein recognition, molecular design, and biomolecular sensing
Platelets in vascular injury and inflammation
Defining neuro-inflammatory processes that contribute to pathology and disease progression in Alzheimer's disease, as well as late CNS effects following radiation exposure.
Human Skin Immunology
Experimental platform using the amphibian Xenopus for research in immunotoxicology, fundamental and medical immunology.
Innate cell antiviral responses, allergic inflammation, mucosal/airway immunity, vaccine responses
Specificity and role of CD4 T cells in response to vaccination and infection
Molecular determinants of and clinical outcomes related to normal and abnormal development of the adaptive immune system in human infants.
Immune-pathogenesis of Viral Infections
Cellular and molecular mechanisms of heart development, disease, and regeneration; Transcriptional regulation of fibroblast plasticity and cardiac fibrosis
Understanding how regulation of RNA Polymerase II activity regulates cellular differentiation, with a focus on erythropoiesis. Delineating epigenetic control of normal erythropoiesis; determining the contribution of disrupted epigenetic regulation to inherited anemias.
Exploring the mechanisms underlying gene-environment interactions in pregnancy; exploring the role of tryptophan catabolism in pregnancy and on the metabolic health of mother and offspring.
Immune responses to respiratory viruses and experimental vaccines