URMC / Biochemistry & Biophysics / Research / Facilities / Structural Biology & Biophysics Facility / Services Services We offer support services and access to state-of-the-art instruments to determine macromolecular X-ray crystal structures, and to investigate protein-protein, protein-nucleic acid, or protein-small molecule interactions. Structural Biology Services X-ray Diffraction Crystal Screening X-ray Diffraction Data Collection and Data Processing Synchrotron-Radiation X-ray Data Collection X-ray Crystal Structure Determination Cryo-Electron Microscopy (cryo-EM) Structure Determination Homology Modeling (And Notes About Docking) Offline Software Installation Molecular Interaction Services Measure Kinetic Rate Constants and Affinities of Molecular Interactions Affinities and Thermodynamic Basis of Molecular Interactions Fluorescent Monitoring of Molecular Interactions Determination of Molecular or Particle Size Services Protein or RNA secondary structure and thermal stability by circular dichroism High Pressure Homogenizer for Cell Lysis