Publications

• 1. Schmierer J
  2. Takimoto T
  Functional Analysis of GRSF1 in the Nuclear Export and Translation of Influenza A Virus mRNAs.; Viruses; Vol 16(7). 2024 Jul 16.
• 1. Hardy K
  2. Lutz M
  3. Takimoto T
  Human coronavirus NL63 nsp1 induces degradation of RNA polymerase II to inhibit host protein synthesis.; PLoS pathogens; Vol 20(6), pp. e1012329. 2024 Jun 20.
• 1. Lutz M
  2. Schmierer J
  3. Takimoto T
  Host adaptive mutations in the 2009 H1N1 pandemic influenza A virus PA gene regulate translation efficiency of viral mRNAs via GRSF1.; Communications biology; Vol 5(1), pp. 1102. 2022 Jan 17.
• 1. Raymonda MH
  2. Ciesla JH
  3. Monaghan M
  4. Leach J
  5. Asantewaa G
  6. Smorodintsev-Schiller LA
  7. Lutz MM
  8. Schafer XL
  9. Takimoto T
  10. Dewhurst S
  11. Munger J
  12. Harris IS
  Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro.; Virology; Vol 566. 2021 Nov 27.
• 1. Kurebayashi Y
  2. Bajimaya S
  3. Watanabe M
  4. Lim N
  5. Lutz M
  6. Dunagan M
  7. Takimoto T
  Human parainfluenza virus type 1 regulates cholesterol biosynthesis and establishes quiescent infection in human airway cells.; PLoS pathogens; Vol 17(9). 2021 Sep.
• 1. Dunagan MM
  2. Hardy K
  3. Takimoto T
  Impact of Influenza A Virus Shutoff Proteins on Host Immune Responses.; Vaccines; Vol 9(6). 2021 Jun 10.
• 1. Genoyer E
  2. Kulej K
  3. Hung CT
  4. Thibault PA
  5. Azarm K
  6. Takimoto T
  7. Garcia BA
  8. Lee B
  9. Lakdawala S
  10. Weitzman MD
  11. López CB
  The Viral Polymerase Complex Mediates the Interaction of Viral Ribonucleoprotein Complexes with Recycling Endosomes during Sendai Virus Assembly.; mBio; Vol 11(4). 2020 Aug 25.
• 1. Scaggs Huang F
  2. Bernstein DI
  3. Slobod KS
  4. Portner A
  5. Takimoto T
  6. Russell CJ
  7. Meagher M
  8. Jones BG
  9. Sealy RE
  10. Coleclough C
  11. Branum K
  12. Dickey M
  13. Buschle K
  14. McNeal M
  15. Makowski M
  16. Nakamura A
  17. Hurwitz JL
  Safety and immunogenicity of an intranasal sendai virus-based vaccine for human parainfluenza virus type I and respiratory syncytial virus (SeVRSV) in adults.; Human vaccines & immunotherapeutics. 2020 Aug 04.
• 1. Lutz Iv MM
  2. Dunagan MM
  3. Kurebayashi Y
  4. Takimoto T
  Key Role of the Influenza A Virus PA Gene Segment in the Emergence of Pandemic Viruses.; Viruses; Vol 12(4). 2020 Mar 26.
• 1. Chaimayo C
  2. Dunagan M
  3. Hayashi T
  4. Santoso N
  5. Takimoto T
  Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activity.; PLoS pathogens; Vol 14(11). 2018 Nov 29.
• 1. Bajimaya S
  2. Frankl T
  3. Hayashi T
  4. Takimoto T
  Cholesterol is required for stability and infectivity of influenza A and respiratory syncytial viruses.; Virology; Vol 510. 2017 Jul 24.
• 1. Russell CJ
  2. Jones BG
  3. Sealy RE
  4. Surman SL
  5. Mason JN
  6. Hayden RT
  7. Tripp RA
  8. Takimoto T
  9. Hurwitz JL
  A Sendai virus recombinant vaccine expressing a gene for truncated human metapneumovirus (hMPV) fusion protein protects cotton rats from hMPV challenge.; Virology; Vol 509. 2017 Jun 09.
• 1. Chaimayo C
  2. Hayashi T
  3. Underwood A
  4. Hodges E
  5. Takimoto T
  Selective incorporation of vRNP into influenza A virions determined by its specific interaction with M1 protein.; Virology; Vol 505. 2017 May.
• 1. Bajimaya S
  2. Hayashi T
  3. Frankl T
  4. Bryk P
  5. Ward B
  6. Takimoto T
  Cholesterol reducing agents inhibit assembly of type I parainfluenza viruses.; Virology; Vol 501. 2017 Jan 15.
• 1. Bajimaya S
  2. Hayashi T
  3. Takimoto T
  Rescue of Sendai Virus from Cloned cDNA.; Methods in molecular biology (Clifton, N.J.); Vol 1602. 2017.
• 1. Hayashi T
  2. Chaimayo C
  3. McGuinness J
  4. Takimoto T
  Critical role of the PA-X C-terminal domain of influenza A virus on its subcellular localization and shutoff activity.; Journal of virology. 2016 May 25.
• 1. Stone R
  2. Hayashi T
  3. Bajimaya S
  4. Hodges E
  5. Takimoto T
  Critical role of Rab11a-mediated recycling endosomes in the assembly of type I parainfluenza viruses.; Virology; Vol 487. 2016 Jan.
• 1. Hayashi T
  2. Chaimayo C
  3. Takimoto T
  Impact of influenza PA-X on host response.; Oncotarget; Vol 6(23). 2015 Aug 14.
• 1. Hayashi T
  2. Wills S
  3. Bussey KA
  4. Takimoto T
  Identification of Influenza A Virus PB2 Residues Involved in Enhanced Polymerase Activity and Virus Growth in Mammalian Cells at Low Temperatures.; Journal of virology; Vol 89(15). 2015 Aug.
• 1. Hayashi T
  2. MacDonald LA
  3. Takimoto T
  Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses.; Journal of virology; Vol 89(12). 2015 Jun.
• 1. Fukushima K
  2. Takahashi T
  3. Ueyama H
  4. Takaguchi M
  5. Ito S
  6. Oishi K
  7. Minami A
  8. Ishitsubo E
  9. Tokiwa H
  10. Takimoto T
  11. Suzuki T
  Amino acid substitutions contributing to α2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase.; FEBS letters; Vol 589(11). 2015 May 8.
• 1. Zhan X
  2. Slobod KS
  3. Jones BG
  4. Sealy RE
  5. Takimoto T
  6. Boyd K
  7. Surman S
  8. Russell CJ
  9. Portner A
  10. Hurwitz JL
  Sendai virus recombinant vaccine expressing a secreted, unconstrained respiratory syncytial virus fusion protein protects against RSV in cotton rats.; International immunology; Vol 27(5). 2015 May.
• 1. Fukushima K
  2. Takahashi T
  3. Ito S
  4. Takaguchi M
  5. Takano M
  6. Kurebayashi Y
  7. Oishi K
  8. Minami A
  9. Kato T
  10. Park EY
  11. Nishimura H
  12. Takimoto T
  13. Suzuki T
  Terminal sialic acid linkages determine different cell infectivities of human parainfluenza virus type 1 and type 3.; Virology; Vol 464-465. 2014 Sep.
• 1. Bialas KM
  2. Bussey KA
  3. Stone RL
  4. Takimoto T
  Specific nucleoprotein residues affect influenza virus morphology.; Journal of virology; Vol 88(4). 2014 Feb.
• 1. Desmet EA
  2. Bussey KA
  3. Stone R
  4. Takimoto T
  Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis.; Journal of virology; Vol 87(6). 2013 Mar.
• 1. Stone R
  2. Takimoto T
  Critical role of the fusion protein cytoplasmic tail sequence in parainfluenza virus assembly.; PloS one; Vol 8(4). 2013.
• 1. Noronha JM
  2. Liu M
  3. Squires RB
  4. Pickett BE
  5. Hale BG
  6. Air GM
  7. Galloway SE
  8. Takimoto T
  9. Schmolke M
  10. Hunt V
  11. Klem E
  12. García-Sastre A
  13. McGee M
  14. Scheuermann RH
  Influenza virus sequence feature variant type analysis: evidence of a role for NS1 in influenza virus host range restriction.; Journal of virology; Vol 86(10). 2012 May.
• 1. MacDonald LA
  2. Aggarwal S
  3. Bussey KA
  4. Desmet EA
  5. Kim B
  6. Takimoto T
  Molecular interactions and trafficking of influenza A virus polymerase proteins analyzed by specific monoclonal antibodies.; Virology; Vol 426(1). 2012 Apr 25.
• 1. Jones BG
  2. Sealy RE
  3. Rudraraju R
  4. Traina-Dorge VL
  5. Finneyfrock B
  6. Cook A
  7. Takimoto T
  8. Portner A
  9. Hurwitz JL
  Sendai virus-based RSV vaccine protects African green monkeys from RSV infection.; Vaccine; Vol 30(5). 2012 Jan 20.
• 1. Bialas KM
  2. Desmet EA
  3. Takimoto T
  Specific residues in the 2009 H1N1 swine-origin influenza matrix protein influence virion morphology and efficiency of viral spread in vitro.; PloS one; Vol 7(11). 2012.
• 1. Aggarwal S
  2. Dewhurst S
  3. Takimoto T
  4. Kim B
  Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex.; The Journal of biological chemistry; Vol 286(40). 2011 Oct 7.
• 1. Bussey KA
  2. Desmet EA
  3. Mattiacio JL
  4. Hamilton A
  5. Bradel-Tretheway B
  6. Bussey HE
  7. Kim B
  8. Dewhurst S
  9. Takimoto T
  PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells.; Journal of virology; Vol 85(14). 2011 Jul.
• 1. Noble E
  2. Mathews DH
  3. Chen JL
  4. Turner DH
  5. Takimoto T
  6. Kim B
  Biophysical analysis of influenza A virus RNA promoter at physiological temperatures.; The Journal of biological chemistry; Vol 286(26). 2011 Jul 1.
• 1. Guo H
  2. Santiago F
  3. Lambert K
  4. Takimoto T
  5. Topham DJ
  T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model.; Journal of virology; Vol 85(1). 2011 Jan.
• 1. Desmet EA
  2. Hollenbaugh JA
  3. Sime PJ
  4. Wright TW
  5. Topham DJ
  6. Sant AJ
  7. Takimoto T
  8. Dewhurst S
  9. Maggirwar SB
  Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells.; Virology; Vol 400(2). 2010 May 10.
• 1. Bussey KA
  2. Bousse TL
  3. Desmet EA
  4. Kim B
  5. Takimoto T
  PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells.; Journal of virology; Vol 84(9). 2010 May.
• 1. Aggarwal S
  2. Bradel-Tretheway B
  3. Takimoto T
  4. Dewhurst S
  5. Kim B
  Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex.; PloS one; Vol 5(4). 2010.
• 1. Chambers R
  2. Takimoto T
  Trafficking of Sendai virus nucleocapsids is mediated by intracellular vesicles.; PloS one; Vol 5(6). 2010.
• 1. Chambers R
  2. Takimoto T
  Antagonism of innate immunity by paramyxovirus accessory proteins.; Viruses; Vol 1(3). 2009 Dec.
• 1. Chambers R
  2. Takimoto T
  Host specificity of the anti-interferon and anti-apoptosis activities of parainfluenza virus P/C gene products.; The Journal of general virology; Vol 90(Pt 8). 2009 Aug.
• 1. Bradel-Tretheway BG
  2. Kelley Z
  3. Chakraborty-Sett S
  4. Takimoto T
  5. Kim B
  6. Dewhurst S
  The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit.; The Journal of general virology; Vol 89(Pt 12). 2008 Dec.
• 1. Zhan X
  2. Slobod KS
  3. Krishnamurthy S
  4. Luque LE
  5. Takimoto T
  6. Jones B
  7. Surman S
  8. Russell CJ
  9. Portner A
  10. Hurwitz JL
  Sendai virus recombinant vaccine expressing hPIV-3 HN or F elicits protective immunity and combines with a second recombinant to prevent hPIV-1, hPIV-3 and RSV infections.; Vaccine; Vol 26(27-28). 2008 Jun 25.
• 1. Zhan X
  2. Hurwitz JL
  3. Krishnamurthy S
  4. Takimoto T
  5. Boyd K
  6. Scroggs RA
  7. Surman S
  8. Portner A
  9. Slobod KS
  Respiratory syncytial virus (RSV) fusion protein expressed by recombinant Sendai virus elicits B-cell and T-cell responses in cotton rats and confers protection against RSV subtypes A and B.; Vaccine; Vol 25(52). 2007 Dec 17.
• 1. Brown SA
  2. Hurwitz JL
  3. Zirkel A
  4. Surman S
  5. Takimoto T
  6. Alymova I
  7. Coleclough C
  8. Portner A
  9. Doherty PC
  10. Slobod KS
  A recombinant Sendai virus is controlled by CD4+ effector T cells responding to a secreted human immunodeficiency virus type 1 envelope glycoprotein.; Journal of virology; Vol 81(22). 2007 Nov.
• 1. Bousse T
  2. Chambers RL
  3. Scroggs RA
  4. Portner A
  5. Takimoto T
  Human parainfluenza virus type 1 but not Sendai virus replicates in human respiratory cells despite IFN treatment.; Virus research; Vol 121(1). 2006 Oct.
• 1. Bousse T
  2. Takimoto T
  Mutation at residue 523 creates a second receptor binding site on human parainfluenza virus type 1 hemagglutinin-neuraminidase protein.; Journal of virology; Vol 80(18). 2006 Sep.
• 1. Krishnamurthy S
  2. Takimoto T
  3. Scroggs RA
  4. Portner A
  Differentially regulated interferon response determines the outcome of Newcastle disease virus infection in normal and tumor cell lines.; Journal of virology; Vol 80(11). 2006 Jun.
• 1. Alymova IV
  2. Portner A
  3. Takimoto T
  4. Boyd KL
  5. Babu YS
  6. McCullers JA
  The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae.; Antimicrobial agents and chemotherapy; Vol 49(1). 2005 Jan.
• 1. Takimoto T
  2. Hurwitz JL
  3. Zhan X
  4. Krishnamurthy S
  5. Prouser C
  6. Brown B
  7. Coleclough C
  8. Boyd K
  9. Scroggs RA
  10. Portner A
  11. Slobod KS
  Recombinant Sendai virus as a novel vaccine candidate for respiratory syncytial virus.; Viral immunology; Vol 18(2). 2005.
• 1. Bousse TL
  2. Taylor G
  3. Krishnamurthy S
  4. Portner A
  5. Samal SK
  6. Takimoto T
  Biological significance of the second receptor binding site of Newcastle disease virus hemagglutinin-neuraminidase protein.; Journal of virology; Vol 78(23). 2004 Dec.