URMC / Labs / Sarkar Lab / Publications Publications Sarkar S Microglial ion channels: Key players in non-cell autonomous neurodegeneration.; Neurobiology of disease; Vol 174, pp. 105861. 2022 Sep 14. Langley MRRangaraju SDey ASarkar S Editorial: Environmental Effect on Neuroinflammation and Neurodegeneration.; Frontiers in cellular neuroscience; Vol 16, pp. 935190. 2022 Jun 21. Hallacli EKayatekin CNazeen SWang XHSheinkopf ZSathyakumar SSarkar SJiang XDong XDi Maio RWang WKeeney MTFelsky DSandoe JVahdatshoar AUdeshi NDMani DRCarr SALindquist SDe Jager PLBartel DPMyers CLGreenamyre JTFeany MBSunyaev SRChung CYKhurana V The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.; Cell; Vol 185(12), pp. 2035-2056.e33. 2022 Jun 09. Palanisamy BNSarkar SMalovic ESamidurai MCharli AZenitsky GJin HAnantharam VKanthasamy AKanthasamy AG Environmental neurotoxic pesticide exposure induces gut inflammation and enteric neuronal degeneration by impairing enteric glial mitochondrial function in pesticide models of Parkinson's disease: Potential relevance to gut-brain axis inflammation in Parkinson's disease pathogenesis.; The international journal of biochemistry & cell biology; Vol 147, pp. 106225. 2022 May 12. Ghaisas SHarischandra DSPalanisamy BProctor AJin HDutta SSarkar SLangley MZenitsky GAnantharam VKanthasamy APhillips GJKanthasamy A Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study.; Environmental health perspectives; Vol 129(8), pp. 87005. 2021 Aug 19. Sarkar SFeany MB Precision Medicine on the Fly: Using Drosophila to Decipher Gene-Environment Interactions in Parkinson's Disease.; Toxicological sciences : an official journal of the Society of Toxicology; Vol 182(2), pp. 159-167. 2021 Aug 03. Sarkar S Mechanism of Gene-Environment Interactions Driving Glial Activation in Parkinson's Diseases.; Current environmental health reports; Vol 8(3), pp. 203-211. 2021 May 27. Sarkar SBardai FOlsen ALLohr KMZhang YYFeany MB Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo.; Molecular neurodegeneration; Vol 16(1), pp. 33. 2021 May 24. Sarkar SOlsen ALSygnecka KLohr KMFeany MB α-synuclein impairs autophagosome maturation through abnormal actin stabilization.; PLoS genetics; Vol 17(2), pp. e1009359. 2021 Feb 08. Sarkar SNguyen HMMalovic ELuo JLangley MPalanisamy BNSingh NManne SNeal MGabrielle MAbdalla AAnantharam PRokad DPanicker NSingh VAy MCharli AHarischandra DJin LWJin HRangaraju SAnantharam VWulff HKanthasamy AG Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.; The Journal of clinical investigation; Vol 130(8), pp. 4195-4212. 2020 Aug 03. Sarkar SDammer EBMalovic EOlsen ALRaza SAGao TXiao HOliver DLDuong DJoers VSeyfried NHuang MKukar TTansey MGKanthasamy AGRangaraju S Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells.; Frontiers in immunology; Vol 11, pp. 33. 2020 Jan 31. Sarkar SMurphy MADammer EBOlsen ALRangaraju SFraenkel EFeany MB Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy.; NPJ Parkinson's disease; Vol 6(1), pp. 40. 2020 Jan 11. Ghaisas SLangley MRPalanisamy BNDutta SNarayanaswamy KPlummer PJSarkar SAy MJin HAnantharam VKanthasamy AKanthasamy AG MitoPark transgenic mouse model recapitulates the gastrointestinal dysfunction and gut-microbiome changes of Parkinson's disease.; Neurotoxicology; Vol 75, pp. 186-199. 2019 Sep 07. Panicker NSarkar SHarischandra DSNeal MKam TIJin HSaminathan HLangley MCharli ASamidurai MRokad DGhaisas SPletnikova ODawson VLDawson TMAnantharam VKanthasamy AGKanthasamy A Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.; The Journal of experimental medicine; Vol 216(6), pp. 1411-1430. 2019 Apr 29. Harischandra DSRokad DNeal MLGhaisas SManne SSarkar SPanicker NZenitsky GJin HLewis MHuang XAnantharam VKanthasamy AKanthasamy AG Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.; Science signaling; Vol 12(572). 2019 Mar 12. Sarkar SRokad DMalovic ELuo JHarischandra DSJin HAnantharam VHuang XLewis MKanthasamy AKanthasamy AG Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells.; Science signaling; Vol 12(563). 2019 Jan 08. Neal MLuo JHarischandra DSGordon RSarkar SJin HAnantharam VDésaubry LKanthasamy AKanthasamy A Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes.; Glia; Vol 66(10), pp. 2137-2157. 2018 Sep 12. Singh NLawana VLuo JPhong PAbdalla APalanisamy BRokad DSarkar SJin HAnantharam VKanthasamy AGKanthasamy A Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events.; Neurobiology of disease; Vol 117, pp. 82-113. 2018 May 31. Sarkar SMalovic ESarda DLawana VRokad DJin HAnantharam VKanthasamy AKanthasamy AG Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults.; Neurotoxicology; Vol 67, pp. 129-140. 2018 May 30. Anantharam PWhitley EMMahama BKim DSSarkar SSantana CChan AKanthasamy AGKanthasamy ABoss GRRumbeiha WK Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model.; Annals of the New York Academy of Sciences; Vol 1408(1), pp. 61-78. 2017 Nov. Sarkar SMalovic EHarischandra DSNgwa HAGhosh AHogan CRokad DZenitsky GJin HAnantharam VKanthasamy AGKanthasamy A Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes.; Neurotoxicology; Vol 64, pp. 204-218. 2017 May 21. Lawana VSingh NSarkar SCharli AJin HAnantharam VKanthasamy AGKanthasamy A Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System.; Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology; Vol 12(4), pp. 624-660. 2017 May 02. Sarkar SMalovic EPlante BZenitsky GJin HAnantharam VKanthasamy AKanthasamy AG Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility.; Journal of visualized experiments : JoVE. 2017 Apr 13. Langley MGhosh ACharli ASarkar SAy MLuo JZielonka JBrenza TBennett BJin HGhaisas SSchlichtmann BKim DAnantharam VKanthasamy ANarasimhan BKalyanaraman BKanthasamy AG Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.; Antioxidants & redox signaling; Vol 27(14), pp. 1048-1066. 2017 Apr 04. Sharma SCarlson SPuttachary SSarkar SShowman LPutra MKanthasamy AGThippeswamy T Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy.; Neurobiology of disease; Vol 110, pp. 102-121. 2017 Jan 29. Sarkar SMalovic EHarishchandra DSGhaisas SPanicker NCharli APalanisamy BNRokad DJin HAnantharam VKanthasamy AKanthasamy AG Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.; NPJ Parkinson's disease; Vol 3, pp. 30. 2017 Jan 17. Gordon RSingh NLawana VGhosh AHarischandra DSJin HHogan CSarkar SRokad DPanicker NAnantharam VKanthasamy AGKanthasamy A Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease.; Neurobiology of disease; Vol 93, pp. 96-114. 2016 May 02. Panicker NSaminathan HJin HNeal MHarischandra DSGordon RKanthasamy KLawana VSarkar SLuo JAnantharam VKanthasamy AGKanthasamy A Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(27), pp. 10058-77. 2015 Jul 08.