Projects

ABO Immune Complexes Cause Endothelial Cell Damage

We are using electric cell-substrate impedance sensing (ECIS) and confocal microscopy, as well as other assays, to observe and quantify endothelial cell damage after exposure to non-identical ABO type plasma in vitro. This involves the generation of ABO immune complexes by mixing concentrated O and A plasmas together, the effects of which mimic ABO non-identical transfusion in vivo.

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Platelet Lysate (PL) Product as a New Means for Topical Application in Wounds

We obtained a patent for developing a new, procoagulable, platelet lysate product to be potentially administered topically for bleeds in both trauma and surgical settings. We are using thromboelastography (TEG), platelet and whole blood aggregation studies, thrombin generation assay (TGA), as well as flow cytometry to evaluate our product’s effectiveness compared to standard platelet products.

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HIT: Why Are Some Patients More Susceptible Than Others?

We are investigating new means for the diagnosis of heparin induced thrombocytopenia (HIT), an immune-mediated response to long-term heparin therapy. This project involves the use of flow cytometry of platelets in order to determine whether some patients are biologically more susceptible to HIT than others via differences in platelet membrane receptors.

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Clinical Device Trials in the HTRL

We are partnering with industry sponsors to generate data that supports FDA submissions for new coagulation analyzers and point of care devices.

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Half-dose Platelet Transfusions

In collaboration with the blood bank at URMC, we are developing new protocols and studies to determine the efficacy of half-doses of platelets.

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Research in the Hemostasis and Thrombosis Research Lab

A selection of our other ongoing research projects.

Learn more about Research in the Hemostasis and Thrombosis Research Lab