URMC / Labs / Redmond Lab / Publications Publications Rajendran NKLiu WCahill PARedmond EM Alcohol and vascular endothelial function: Biphasic effect highlights the importance of dose.; Alcohol, clinical & experimental research; Vol 47(8), pp. 1467-1477. 2023 Jul 10. Rajendran NKLiu WCahill PARedmond EM Caveolin-1 inhibition mediates the opposing effects of alcohol on γ-secretase activity in arterial endothelial and smooth muscle cells.; Physiological reports; Vol 11(1), pp. e15544. 2023 Jan. Burtenshaw DRegan BOwen KCollins DMcEneaney DMegson ILRedmond EMCahill PA Exosomal Composition, Biogenesis and Profiling Using Point-of-Care Diagnostics-Implications for Cardiovascular Disease.; Frontiers in cell and developmental biology; Vol 10, pp. 853451. 2022 Jun 01. Rajendran NKLiu WChu CCCahill PARedmond EM Moderate dose alcohol protects against serum amyloid protein A1-induced endothelial dysfunction via both notch-dependent and notch-independent pathways.; Alcoholism, clinical and experimental research. 2021 Sep 29. Molony CKing DDi Luca MKitching MOlayinka AHakimjavadi RJulius LANFitzpatrick EGusti YBurtenshaw DHealy KFinlay EKKernan DLlobera ALiu WMorrow DRedmond EMDucrée JCahill PA Disease-Relevant Single Cell Photonic Signatures Identify S100β Stem Cells and their Myogenic Progeny in Vascular Lesions.; Stem cell reviews and reports. 2021 Mar 17. Di Luca MFitzpatrick EBurtenshaw DLiu WHelt JCHakimjavadi RCorcoran EGusti YSheridan DHarman SLally CRedmond EMCahill PA The calcium binding protein S100β marks hedgehog-responsive resident vascular stem cells within vascular lesions.; NPJ Regenerative medicine; Vol 6(1). 2021 Mar 01. Liu WHarman SDiLuca MBurtenshaw DCorcoran ECahill PARedmond EM Moderate Alcohol Consumption Targets S100β+ Vascular Stem Cells and Attenuates Injury-Induced Neointimal Hyperplasia.; Alcoholism, clinical and experimental research; Vol 44(9). 2020 Sep. King DGlynn MCindric SKernan DO'Connell THakimjavadi RKearney SAckermann TBerbel XMLlobera ASimonsen ULaursen BERedmond EMCahill PADucrée J Label-Free Multi Parameter Optical Interrogation of Endothelial Activation in Single Cells using a Lab on a Disc Platform.; Scientific reports; Vol 9(1). 2019 Mar 11. Burtenshaw DKitching MRedmond EMMegson ILCahill PA Reactive Oxygen Species (ROS), Intimal Thickening, and Subclinical Atherosclerotic Disease.; Frontiers in cardiovascular medicine; Vol 6. 2019. Hatch EMorrow DLiu WCahill PARedmond EM Differential effects of alcohol and its metabolite acetaldehyde on vascular smooth muscle cell Notch signaling and growth.; American journal of physiology. Heart and circulatory physiology; Vol 314(1). 2018 Jan 01. Fitzpatrick EHan XLiu WCorcoran EBurtenshaw DMorrow DHelt JCCahill PARedmond EM Alcohol Reduces Arterial Remodeling by Inhibiting Sonic Hedgehog-Stimulated Stem Cell Antigen-1 Positive Progenitor Stem Cell Expansion.; Alcoholism, clinical and experimental research; Vol 41(12). 2017 Dec. Burtenshaw DHakimjavadi RRedmond EMCahill PA Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate.; Antioxidants (Basel, Switzerland); Vol 6(4). 2017 Nov 14. Cahill PARedmond EM Vascular endothelium - Gatekeeper of vessel health.; Atherosclerosis; Vol 248. 2016 May. Ghatak SReveiller MToia LIvanov AIZhou ZRedmond EMGodfrey TEPeters JH Bile Salts at Low pH Cause Dilation of Intercellular Spaces in In Vitro Stratified Primary Esophageal Cells, Possibly by Modulating Wnt Signaling.; Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract; Vol 20(3). 2016 Mar. Hatch EMorrow DLiu WCahill PARedmond EM Ethanol inhibits γ-secretase proteolytic activity in vascular smooth muscle cells.; Alcoholism, clinical and experimental research; Vol 39(11). 2015 Nov. Doyle AJRedmond EMGillespie DLKnight PACullen JPCahill PAMorrow DJ Differential expression of Hedgehog/Notch and transforming growth factor-β in human abdominal aortic aneurysms.; Journal of vascular surgery; Vol 62(2). 2015 Aug. Mooney CJHakimjavadi RFitzpatrick EKennedy EWalls DMorrow DRedmond EMCahill PA Hedgehog and Resident Vascular Stem Cell Fate.; Stem cells international; Vol 2015. 2015. Kennedy EMooney CJHakimjavadi RFitzpatrick EGuha SCollins LELoscher CEMorrow DRedmond EMCahill PA Adult vascular smooth muscle cells in culture express neural stem cell markers typical of resident multipotent vascular stem cells.; Cell and tissue research; Vol 358(1). 2014 Oct. Gao WFerguson GConnell PWalshe TO'Brien CRedmond EMCahill PA Glucose attenuates hypoxia-induced changes in endothelial cell growth by inhibiting HIF-1α expression.; Diabetes & vascular disease research; Vol 11(4). 2014 Jul. Kennedy EHakimjavadi RGreene CMooney CJFitzpatrick ECollins LELoscher CEGuha SMorrow DRedmond EMCahill PA Embryonic rat vascular smooth muscle cells revisited - a model for neonatal, neointimal SMC or differentiated vascular stem cells?; Vascular cell; Vol 6(1). 2014 Mar 15. Redmond EMLiu WHamm KHatch ECahill PAMorrow D Perivascular delivery of Notch 1 siRNA inhibits injury-induced arterial remodeling.; PloS one; Vol 9(1). 2014. Morrow DHatch EHamm KCahill PARedmond EM Flk-1/KDR mediates ethanol-stimulated endothelial cell Notch signaling and angiogenic activity.; Journal of vascular research; Vol 51(4). 2014. Redmond EMHamm KCullen JPHatch ECahill PAMorrow D Inhibition of patched-1 prevents injury-induced neointimal hyperplasia.; Arteriosclerosis, thrombosis, and vascular biology; Vol 33(8). 2013 Aug. Cahill PARedmond EM Alcohol and cardiovascular disease--modulation of vascular cell function.; Nutrients; Vol 4(4). 2012 Apr. Redmond EMCahill PA The NOX-ROS connection: targeting Nox1 control of N-cadherin shedding in vascular smooth muscle cells.; Cardiovascular research; Vol 93(3). 2012 Mar 01. Redmond EMGuha SWalls DCahill PA Investigational Notch and Hedgehog inhibitors--therapies for cardiovascular disease.; Expert opinion on investigational drugs; Vol 20(12). 2011 Dec. Liu WRedmond EMMorrow DCullen JP Differential effects of daily-moderate versus weekend-binge alcohol consumption on atherosclerotic plaque development in mice.; Atherosclerosis; Vol 219(2). 2011 Dec. Walshe TEConnell PCryan LFerguson GGardiner TMorrow DRedmond EMO'Brien CCahill PA Microvascular retinal endothelial and pericyte cell apoptosis in vitro: role of hedgehog and Notch signaling.; Investigative ophthalmology & visual science; Vol 52(7). 2011 Jun 23. Zhao JWang WHa CHKim JYWong CRedmond EMHamik AJain MKFeng GSJin ZG Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis.; Arteriosclerosis, thrombosis, and vascular biology; Vol 31(5). 2011 May. Guha SCullen JPMorrow DColombo ALally CWalls DRedmond EMCahill PA Glycogen synthase kinase 3 beta (GSK-3b) positively regulates Notch signaling in vascular smooth muscle cells; role in cell proliferation and survival.; Basic Res Cardiol. 2011 Jan 01. Banerjee SLin CFSkinner KASchiffhauer LMPeacock JHicks DGRedmond EMMorrow DHuston AShayne MLangstein HNMiller-Graziano CLStrickland JO'Donoghue LDe AK Heat shock protein 27 differentiates tolerogenic macrophages that may support human breast cancer progression.; Cancer research; Vol 71(2). 2011 Jan 15. Morrow DCullen JPLiu WCahill PARedmond EM Alcohol inhibits smooth muscle cell proliferation via regulation of the Notch signaling pathway.; Arteriosclerosis, thrombosis, and vascular biology; Vol 30(12). 2010 Dec. Morrow DJAvissar NEToia LRedmond EMWatson TJJones CRaymond DPLitle VPeters JH Pathogenesis of Barrett's esophagus: bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cells.; Surgery; Vol 146(4). 2009 Oct. Morrow DCullen JPLiu WGuha SSweeney CBirney YACollins NWalls DRedmond EMCahill PA Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A.; Arteriosclerosis, thrombosis, and vascular biology; Vol 29(7). 2009 Jul. Redmond EMMorrow DKundimi SMiller-Graziano CLCullen JP Acetaldehyde stimulates monocyte adhesion in a P-selectin- and TNFalpha-dependent manner.; Atherosclerosis; Vol 204(2). 2009 Jun. Morrow DGuha SSweeney CBirney YWalshe TO'Brien CWalls DRedmond EMCahill PA Notch and vascular smooth muscle cell phenotype.; Circulation research; Vol 103(12). 2008 Dec 05. Skill NJTheodorakis NGWang YNWu JMRedmond EMSitzmann JV Role of cyclooxygenase isoforms in prostacyclin biosynthesis and murine prehepatic portal hypertension.; American journal of physiology. Gastrointestinal and liver physiology; Vol 295(5). 2008 Nov. Morrow DCullen JPCahill PARedmond EM Ethanol stimulates endothelial cell angiogenic activity via a Notch- and angiopoietin-1-dependent pathway.; Cardiovascular research; Vol 79(2). 2008 Jul 15. Cullen JPMorrow DJin Yvon Offenberg Sweeney NSitzmann JVCahill PARedmond EM Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes.; Atherosclerosis; Vol 195(1). 2007 Nov. Morrow DCullen JPCahill PARedmond EM Cyclic strain regulates the Notch/CBF-1 signaling pathway in endothelial cells: role in angiogenic activity.; Arteriosclerosis, thrombosis, and vascular biology; Vol 27(6). 2007 Jun. Cullen JPMorrow DJin YCurley BRobinson ASitzmann JVCahill PARedmond EM Resveratrol, a polyphenolic phytostilbene, inhibits endothelial monocyte chemotactic protein-1 synthesis and secretion.; Journal of vascular research; Vol 44(1). 2007. Morrow DSweeney CBirney YAGuha SCollins NCummins PMMurphy RWalls DRedmond EMCahill PA Biomechanical regulation of hedgehog signaling in vascular smooth muscle cells in vitro and in vivo.; American journal of physiology. Cell physiology; Vol 292(1). 2007 Jan. Morrow DSweeney CGuha SWalshe TO'Brien CWalls DRedmond EMCahill PA Notch signaling and vascular cell fate--how vascular cells respond to stress.; Wiener klinische Wochenschrift; Vol 119(11-12 Suppl 1). 2007. Cummins PMvon OSN KMBirney YARedmond EMCahill PA Cyclic strain-mediated matrix metalloproteinase regulation within the vascular endothelium: A force to be reckoned with.; AJP Heart and Circulatory Physiol; Vol 292(1), pp. 28-42. 2007 Jan 01. Morrow DScheller ABirney YASweeney CGuha SCummins PMMurphy RWalls DRedmond EMCahill PA Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro.; American journal of physiology. Cell physiology; Vol 289(5). 2005 Nov. Cullen JPSayeed SJin YTheodorakis NGSitzmann JVCahill PARedmond EM Ethanol inhibits monocyte chemotactic protein-1 expression in interleukin-1{beta}-activated human endothelial cells.; American journal of physiology. Heart and circulatory physiology; Vol 289(4). 2005 Oct. Cullen JPSayeed SKim YTheodorakis NGSitzmann JVCahill PARedmond EM Ethanol inhibits pulse pressure-induced vascular smooth muscle cell migration by differentially modulating plasminogen activator inhibitor type 1, matrix metalloproteinase-2 and -9.; Thrombosis and haemostasis; Vol 94(3). 2005 Sep. Von Offenberg Sweeney NCummins PMCotter EJFitzpatrick PABirney YARedmond EMCahill PA Cyclic strain-mediated regulation of vascular endothelial cell migration and tube formation.; Biochemical and biophysical research communications; Vol 329(2). 2005 Apr 08. Morrow DSweeney CBirney YACummins PMWalls DRedmond EMCahill PA Cyclic strain inhibits Notch receptor signaling in vascular smooth muscle cells in vitro.; Circulation research; Vol 96(5). 2005 Mar 18. von Offenberg Sweeney NCummins PMBirney YACullen JPRedmond EMCahill PA Cyclic strain-mediated regulation of endothelial matrix metalloproteinase-2 expression and activity.; Cardiovascular research; Vol 63(4). 2004 Sep 1. Sweeney CMorrow DBirney YACoyle SHennessy CScheller ACummins PMWalls DRedmond EMCahill PA Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 18(12). 2004 Sep. von Offenberg Sweeney NCummins PMBirney YARedmond EMCahill PA Cyclic strain-induced endothelial MMP-2: role in vascular smooth muscle cell migration.; Biochemical and biophysical research communications; Vol 320(2). 2004 Jul 23. Birney YASweeney CHCappadona CRSitzmann JVCummins PMRedmond EMCahill PA Pulse pressure-induced transmural fluid flux increases bovine aortic smooth muscle cell apoptosis in a mitogen activated protein kinase dependent manner.; Journal of vascular research; Vol 41(4). 2004 Jul. Cullen JPNicholl SMSayeed SSitzmann JVOkada SSCahill PARedmond EM Plasminogen activator inhibitor-1 deficiency enhances flow-induced smooth muscle cell migration.; Thrombosis research; Vol 114(1). 2004. Birney YRedmond EMSitzmann JVCahill PA Eicosanoids in cirrhosis and portal hypertension.; Prostaglandins & other lipid mediators; Vol 72(1-2). 2003 Oct. Theodorakis NGWang YNSkill NJMetz MACahill PARedmond EMSitzmann JV The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice.; Gastroenterology; Vol 124(5). 2003 May. Cullen JPSayeed SSawai RSTheodorakis NGCahill PASitzmann JVRedmond EM Pulsatile flow-induced angiogenesis: role of G(i) subunits.; Arteriosclerosis, thrombosis, and vascular biology; Vol 22(10). 2002 Oct 1. Sayeed SCullen JPCoppage MSitzmann JVRedmond EM Ethanol differentially modulates the expression and activity of cell cycle regulatory proteins in rat aortic smooth muscle cells.; European journal of pharmacology; Vol 445(3). 2002 Jun 12. Cahill PARedmond EMSitzmann JV Endothelial dysfunction in cirrhosis and portal hypertension.; Pharmacology & therapeutics; Vol 89(3). 2001 Mar. Redmond EMCullen JPCahill PASitzmann JVStefansson SLawrence DAOkada SS Endothelial cells inhibit flow-induced smooth muscle cell migration: role of plasminogen activator inhibitor-1.; Circulation; Vol 103(4). 2001 Jan 30. Redmond EMSitzmann JVCahill PA Potential mechanisms for cardiovascular protective effect of ethanol.; Acta pharmacologica Sinica; Vol 21(5). 2000 May. Cappadona CRedmond EMTheodorakis NGMcKillop IHHendrickson RChhabra ASitzmann JVCahill PA Phenotype dictates the growth response of vascular smooth muscle cells to pulse pressure in vitro.; Experimental cell research; Vol 250(1). 1999 Jul 10. Hendrickson RJOkada SSCahill PAYankah ESitzmann JVRedmond EM Ethanol inhibits basal and flow-induced vascular smooth muscle cell migration in vitro.; The Journal of surgical research; Vol 84(1). 1999 Jun 01. Hendrickson RJCahill PASitzmann JVRedmond EM Ethanol enhances basal and flow-stimulated nitric oxide synthase activity in vitro by activating an inhibitory guanine nucleotide binding protein.; The Journal of pharmacology and experimental therapeutics; Vol 289(3). 1999 Jun. Hendrickson RJCappadona CYankah ENSitzmann JVCahill PARedmond EM Sustained pulsatile flow regulates endothelial nitric oxide synthase and cyclooxygenase expression in co-cultured vascular endothelial and smooth muscle cells.; Journal of molecular and cellular cardiology; Vol 31(3). 1999 Mar. Redmond EMCahill PAHirsch MWang YNSitzmann JVOkada SS Effect of pulse pressure on vascular smooth muscle cell migration: the role of urokinase and matrix metalloproteinase.; Thrombosis and haemostasis; Vol 81(2). 1999 Feb. Hendrickson RJCahill PAMcKillop IHSitzmann JVRedmond EM Ethanol inhibits mitogen activated protein kinase activity and growth of vascular smooth muscle cells in vitro.; European journal of pharmacology; Vol 362(2-3). 1998 Dec 04. Kouretas PCHannan RLKapur NKHendrickson RRedmond EMMyers AKKim YDCahill PASitzmann JV Non-anticoagulant heparin increases endothelial nitric oxide synthase activity: role of inhibitory guanine nucleotide proteins.; Journal of molecular and cellular cardiology; Vol 30(12). 1998 Dec. Mebazaa AWetzel RCDodd-o JMRedmond EMShah AMMaeda KMaistre GLakatta EGRobotham JL Potential paracrine role of the pericardium in the regulation of cardiac function.; Cardiovascular research; Vol 40(2). 1998 Nov. Cahill PAHou MCHendrickson RWang YNZhang SRedmond EMSitzman JV Increased expression of endothelin receptors in the vasculature of portal hypertensive rats: role in splanchnic hemodynamics.; Hepatology (Baltimore, Md.); Vol 28(2). 1998 Aug. Redmond EMCahill PASitzmann JV Flow-mediated regulation of G-protein expression in cocultured vascular smooth muscle and endothelial cells.; Arteriosclerosis, thrombosis, and vascular biology; Vol 18(1). 1998 Jan. Hou MCCahill PAZhang SWang YNHendrickson RJRedmond EMSitzmann JV Enhanced cyclooxygenase-1 expression within the superior mesenteric artery of portal hypertensive rats: role in the hyperdynamic circulation.; Hepatology (Baltimore, Md.); Vol 27(1). 1998 Jan. Redmond EMCahill PASitzmann JV Flow-mediated regulation of endothelin receptors in cocultured vascular smooth muscle cells: an endothelium-dependent effect.; Journal of vascular research; Vol 34(6). 1997 Nov. Hou MCCahill PAZhang SRedmond EMSitzmann JV Enhanced G-protein-induced relaxation in portal hypertensive rats: role of nitric oxide.; Hepatology (Baltimore, Md.); Vol 26(1). 1997 Jul. Cahill PARedmond EMHodges RZhang SSitzmann JV Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats.; Journal of hepatology; Vol 25(3). 1996 Sep. Redmond EMCahill PAHodges RZhang SSitzmann JV Regulation of endothelin receptors by nitric oxide in cultured rat vascular smooth muscle cells.; Journal of cellular physiology; Vol 166(3). 1996 Mar. Cahill PARedmond EMWu YSitzmann JV Regulation of atrial natriuretic factor receptors in portal hypertensive rabbits.; Journal of hepatology; Vol 24(2). 1996 Feb. Redmond EMCahill PASitzmann JV Perfused transcapillary smooth muscle and endothelial cell co-culture--a novel in vitro model.; In vitro cellular & developmental biology. Animal; Vol 31(8). 1995 Sep. Cahill PAFoster CRedmond EMGingalewski CWu YSitzmann JV Enhanced nitric oxide synthase activity in portal hypertensive rabbits.; Hepatology (Baltimore, Md.); Vol 22(2). 1995 Aug. Cahill PARedmond EMFoster CSitzmann JV Nitric oxide regulates angiotensin II receptors in vascular smooth muscle cells.; European journal of pharmacology; Vol 288(2). 1995 Jan 16. Redmond EMCherian MNWetzel RC 17 beta-Estradiol inhibits flow- and acute hypoxia-induced prostacyclin release from perfused endocardial endothelial cells.; Circulation; Vol 90(5). 1994 Nov. Kent ARedmond EMKeenan AK The ANF-C receptor is not linked to adenylyl cyclase inhibition in bovine pulmonary artery endothelial cells.; Life sciences; Vol 51(18). 1992. Cahill PARedmond EMKeenan AK Vascular atrial natriuretic factor receptor subtypes are not independently regulated by atrial peptides.; The Journal of biological chemistry; Vol 265(35). 1990 Dec 15. Redmond EMCahill PAKeenan AK Atrial natriuretic factor recognizes two receptor subtypes in endothelial cells cultured from bovine pulmonary artery.; FEBS letters; Vol 269(1). 1990 Aug 20.