URMC / Labs / Rangel-Moreno Lab / Publications Publications Gupta ATaneja VRangel Moreno JAbhimanyu Ahmed MNaqvi NChauhan KSde León DTRamírez-Martínez GJiménez-Alvarez LLuna-Rivero CZuniga JKaushal DKhader SA Mast cells promote pathology and susceptibility in tuberculosis.; bioRxiv : the preprint server for biology. 2024 Sep 09. Bell RDBrendel MKonnaris MAXiang JOtero MFontana MABai ZKrenitsky DMMeednu NRangel-Moreno JScheel-Toellner DCarr HNayar SMcMurray JDiCarlo EAnolik JHDonlin LTOrange DEKenney HMSchwarz EMFiler AIvashkiv LBWang F Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue.; Nature communications; Vol 15(1), pp. 7503. 2024 Aug 29. Van Buren EAzzara DRangel-Moreno JGarcia-Hernandez MLMurphy SPCohen EDLewis ELin XPark HR Single-cell RNA sequencing reveals placental response under environmental stress.; Nature communications; Vol 15(1), pp. 6549. 2024 Aug 02. Law CWacleche VSCao YPillai ASowerby JHancock BHorisberger ABracero SSkidanova VLi ZAdejoorin IDillon EBenque IJNunez DPSimmons DPKeegan JChen LBaker TBrohawn PZAl-Mossawi HHao LYJones BRao NQu YAlves SEJonsson AHShaw KSVleugels RAMassarotti ECostenbader KHBrenner MBLederer JAHultquist JFChoi JRao DA Publisher Correction: Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus.; Nature. 2024 Jul 26. Law CWacleche VSCao YPillai ASowerby JHancock BHorisberger ABracero SSkidanova VLi ZAdejoorin IDillon EBenque IJNunez DPSimmons DPKeegan JChen LBaker TBrohawn PZAl-Mossawi HHao LYJones BRao NQu YAlves SEJonsson AHShaw KSVleugels RAMassarotti ECostenbader KHBrenner MBLederer JAHultquist JFChoi JRao DA Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus.; Nature. 2024 Jul 10. Ritchlin CTRangel-Moreno JMartino DIsett BPaine ABhattacharya SFox JMeyer EMBao RBruno TTausk Fde la Luz Garcia-Hernandez M Psoriatic arthritis subtypes are phenocopied in humanized mice.; JCI insight; Vol 9(15). 2024 Jul 02. Dunlap GWagner AMeednu NWang RZhang FEkabe JCJonsson AHWei KSakaue SNathan ABykerk VPDonlin LTGoodman SMFirestein GSBoyle DLHolers VMMoreland LWTabechian DPitzalis CFiler ARaychaudhuri SBrenner MBThakar JMcDavid ARao DAAnolik JH Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium.; Nature communications; Vol 15(1), pp. 4991. 2024 Jun 11. Weinand KSakaue SNathan AJonsson AHZhang FWatts GFMAl Suqri MZhu ZRao DAAnolik JHBrenner MBDonlin LTWei KRaychaudhuri S The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis.; Nature communications; Vol 15(1), pp. 4650. 2024 May 31. Bai ZBartelo NAslam MMurphy EAHale CRBlachere NEParveen SSpolaore EDiCarlo EGravallese EMSmith MHFrank MOJiang CSZhang HPyrgaki CLewis MJSikandar SPitzalis CLesnak JBMazhar KPrice TJMalfait AMMiller REZhang FGoodman SDarnell RBWang FOrange DE Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis.; Science translational medicine; Vol 16(742), pp. eadk3506. 2024 Apr 10. Sakaue SWeinand KIsaac SDey KKJagadeesh KKanai MWatts GFMZhu ZBrenner MBMcDavid ADonlin LTWei KPrice ALRaychaudhuri S Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.; Nature genetics. 2024 Apr 09. Gupta AThirunavukkarasu SRangel-Moreno JAhmed MSwanson RVMbandi SKSmrcka AVKaushal DScriba TJKhader SA Phospholipase C epsilon-1 (PLCƐ1) mediates macrophage activation and protection against tuberculosis.; Infection and immunity. 2024 Mar 07. Izmirly PMKim MYCarlucci PMPreisinger KCohen BZDeonaraine KZaminski DDall'Era MKalunian KFava ABelmont HMWu MPutterman CAnolik JBarnas JLDiamond BDavidson AWofsy DKamen DJames JAGuthridge JMApruzzese WRao DAWeisman MHPetri MBuyon JFurie R Longitudinal patterns and predictors of response to standard-of-care therapy in lupus nephritis: data from the Accelerating Medicines Partnership Lupus Network.; Arthritis research & therapy; Vol 26(1), pp. 54. 2024 Feb 20. Hofstee MISiverino CSaito MMeghwani HTapia-Dean JArveladze SHildebrand MRangel-Moreno JRiool MZeiter SZaat SAJMoriarty TFMuthukrishnan G Staphylococcus aureus Panton-Valentine Leukocidin worsens acute implant-associated osteomyelitis in humanized BRGSF mice.; JBMR plus; Vol 8(2), pp. ziad005. 2024 Jan 04. Constantinesco NJChinnappan BDeVito LJMoras CSrikanth SGarcia-Hernandez MLRangel-Moreno JGopal R Sodium-Glucose Cotransporter-2 Inhibitor, Empagliflozin, Suppresses the Inflammatory Immune Response to Influenza Infection.; ImmunoHorizons; Vol 7(12), pp. 861-871. 2023 Dec 01. Kang JBShen AZGurajala SNathan ARumker LAguiar VRCValencia CLagattuta KAZhang FJonsson AHYazar SAlquicira-Hernandez JKhalili HAnanthakrishnan ANJagadeesh KDey KDaly MJXavier RJDonlin LTAnolik JHPowell JERao DABrenner MBGutierrez-Arcelus MLuo YSakaue SRaychaudhuri S Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution.; Nature genetics; Vol 55(12), pp. 2255-2268. 2023 Nov 30. Zhang FJonsson AHNathan AMillard NCurtis MXiao QGutierrez-Arcelus MApruzzese WWatts GFMWeisenfeld DNayar SRangel-Moreno JMeednu NMarks KEMantel IKang JBRumker LMears JSlowikowski KWeinand KOrange DEGeraldino-Pardilla LDeane KDTabechian DCeponis AFirestein GSMaybury MSahbudin IBen-Artzi AMandelin AMNerviani ALewis MJRivellese FPitzalis CHughes LBHorowitz DDiCarlo EGravallese EMBoyce BFMoreland LWGoodman SMPerlman HHolers VMLiao KPFiler ABykerk VPWei KRao DADonlin LTAnolik JHBrenner MBRaychaudhuri S Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.; Nature; Vol 623(7987), pp. 616-624. 2023 Nov 08. Kenney HMRangel-Moreno JPeng YChen KLBruno JEmbong APritchett EFox JIBecerril-Villanueva EGamboa-Domínguez AQuataert SMuthukrishnan GWood RWKorman BDAnolik JHXing LRitchlin CTSchwarz EMWu CL Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.; Frontiers in immunology; Vol 14, pp. 1237498. 2023 Aug 25. Thirunavukkarasu SAhmed MRosa BABoothby MCho SHRangel-Moreno JMbandi SKSchreiber VGupta AZúñiga JMitreva MKaushal DScriba TJKhader SA Poly(ADP)ribose polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production.; The Journal of clinical investigation. 2023 May 18. Swanson RVGupta AForeman TWLu LChoreno-Parra JAMbandi SKRosa BAAkter SDas SAhmed MGarcia-Hernandez MLSingh DKEsaulova EArtyomov MNGommerman JMehra SZuniga JMitreva MScriba TJRangel-Moreno JKaushal DKhader SA Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control.; Nature immunology. 2023 Apr 03. Ren YZhang SWeeks JRangel-Moreno JHe BXue TRainbolt JMorita YShu YLiu YKates SLSchwarz EMXie C Reduced Angiogenesis and Delayed Endochondral Ossification in CD163-/- Mice Highlights a Role of M2 Macrophages During Bone Fracture Repair.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2023 Mar 27. Weisenfeld DZhang FDonlin LJonsson AHApruzzese WCampbell DRao DAWei KHolers VMGravallese EMoreland LGoodman SBrenner MRaychaudhuri SFiler AAnolik JBykerk VLiao KP Associations between rheumatoid arthritis clinical factors with synovial cell types and states.; Arthritis & rheumatology (Hoboken, N.J.). 2023 Jan 04. Morita YSaito MRangel-Moreno JFranchini AMOwen JRMartinez JCDaiss JLde Mesy Bentley KLKates SLSchwarz EMMuthukrishnan G Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation.; Bone research; Vol 10(1), pp. 56. 2022 Aug 26. Scott NRThirunavukkarasu SRangel-Moreno JGriggs DWKhader SA CWHM-12, an Antagonist of Integrin-Mediated Transforming Growth Factor-Beta Activation Confers Protection During Early Mycobacterium tuberculosis Infection in Mice.; Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2022 Aug 01. Meednu NRangel-Moreno JZhang FEscalera-Rivera KCorsiero EPrediletto EDiCarlo EGoodman SDonlin LTRaychauduri SBombardieri MPitzalis COrange DEMcDavid AAnolik JH Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression.; Cell reports; Vol 39(5). 2022 May 03. Rangel-Moreno JGarcia-Hernandez MLOwen TBarnard JBecerril-Villanueva EKashyap TArgueta CGamboa-Dominguez ATamir SLandesman YGoldman BIRitchlin CTAnolik JH Small molecule inhibitors of nuclear export ameliorate lupus by modulating plasma cell generation and survival.; Arthritis & rheumatology (Hoboken, N.J.). 2022 Mar 25. Carlucci PMLi JFava ADeonaraine KKWofsy DJames JAPutterman CDiamond BDavidson AFine DMMonroy-Trujillo JAtta MGDeJager WGuthridge JMHaag KRao DABrenner MBLederer JAApruzzese WBelmont HMIzmirly PMZaminski DWu MConnery SPayan-Schober FFurie RDall'Era MCho KKamen DKalunian KAnolik JBarnas JIshimori MWeisman MHBuyon JPPetri M High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership.; Rheumatology (Oxford, England). 2022 Feb 25. Garcia-Hernandez MLRangel-Moreno JGarcia-Castaneda MKenney HMPaine AThullen MAnandarajah APSchwarz EMDirksen RTRitchlin CT Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis.; Frontiers in immunology; Vol 13, pp. 1026574. 2022 Jan 07. Chiem KLorenzo MMRangel-Moreno JGarcia-Hernandez MLPark JGNogales ABlasco RMartínez-Sobrido L Bi-Reporter Vaccinia Virus for Tracking Viral Infections In Vitro and In Vivo.; Microbiology spectrum. 2021 Nov 24. Iwanaga NChen KYang HLu SHoffmann JPWanek AMcCombs JESong KRangel-Moreno JNorton EBKolls JK Vaccine-driven lung TRM cells provide immunity against Klebsiella via fibroblast IL-17R signaling.; Science immunology; Vol 6(63). 2021 Sep 10. Deonaraine KKCarlucci PMFava ALi JWofsy DJames JAPutterman CDiamond BDavidson AFine DMMonroy-Trujillo JAtta MGHaag KRao DAApruzzese WBelmont HMIzmirly PMWu MConnery SPayan-Schober FFurie RABerthier CCDall'Era MCho KKamen DLKalunian KAnolik JIshimori MWeisman MHPetri MABuyon JP Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network.; Lupus science & medicine; Vol 8(1). 2021 Aug. Das SMarin NDEsaulova EAhmed MSwain ARosa BAMitreva MRangel-Moreno JNetea MGBarreiro LBDivangahi MArtyomov MNKaushal DKhader SA Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4+ T Cell Activation and Mycobacterium tuberculosis Control.; mBio. 2021 Jul 13. Zhang FMears JRShakib LBeynor JIShanaj SKorsunsky INathan ADonlin LTRaychaudhuri S IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation.; Genome medicine; Vol 13(1), pp. 64. 2021 Apr 20. Sarkar SSpencer DABarnette PPandey SSutton WFBasu MBurch RECleveland JDRosenberg AFRangel-Moreno JKeefer MCHessell AJHaigwood NLKobie JJ CD4+ T Cells Are Dispensable for Induction of Broad Heterologous HIV Neutralizing Antibodies in Rhesus Macaques.; Frontiers in immunology; Vol 12. 2021. Guerrero GGRangel-Moreno JIslas-Trujillo OSRojas-Espinosa O Intramuscular boosting with hIFN-alpha 2b enhances BCGPhipps-induced protection in a murine model of leprosy; Microbiology Research; Vol 12(3), pp. 711-726. 2021 Jan 01. Muthukrishnan GWallimann ARangel-Moreno JBentley KLMHildebrand MMys KKenney HMSumrall ETDaiss JLZeiter SRichards RGSchwarz EMMoriarty TF Humanized Mice Exhibit Exacerbated Abscess Formation and Osteolysis During the Establishment of Implant-Associated Staphylococcus aureus Osteomyelitis.; Frontiers in immunology; Vol 12. 2021. Esaulova EDas SSingh DKChoreño-Parra JASwain AArthur LRangel-Moreno JAhmed MSingh BGupta AFernández-López LAde la Luz Garcia-Hernandez MBucsan AMoodley CMehra SGarcía-Latorre EZuniga JAtkinson JKaushal DArtyomov MNKhader SA The immune landscape in tuberculosis reveals populations linked to disease and latency.; Cell host & microbe. 2020 Dec 16. Ruiz-Rosado JDRobledo-Avila FCortado HRangel-Moreno JJustice SSYang CSpencer JDBecknell BPartida-Sanchez S Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis.; Journal of the American Society of Nephrology : JASN. 2020 Nov 04. Li LXHole CRRangel-Moreno JKhader SADoering TL Cryptococcus neoformans evades pulmonary immunity by modulating xylose precursor transport.; Infection and immunity. 2020 May 18. Wei KKorsunsky IMarshall JLGao AWatts GFMMajor TCroft APWatts JBlazar PELange JKThornhill TSFiler ARaza KDonlin LTSiebel CWBuckley CDRaychaudhuri SBrenner MB Notch signalling drives synovial fibroblast identity and arthritis pathology.; Nature. 2020 Apr 22. Scott NRSwanson RVAl-Hammadi NDomingo-Gonzalez RRangel-Moreno JKriel BABucsan ANDas SAhmed MMehra STreerat PCruz-Lagunas AJimenez-Alvarez LMuñoz-Torrico MBobadilla-Lozoya KVogl TWalzl Gdu Plessis NKaushal DScriba TZuñiga JKhader S S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis.; The Journal of clinical investigation. 2020 Mar 05. Taya MGarcia-Hernandez MRangel-Moreno JMinor BGibbons EHammes SR Neutrophil elastase from myeloid cells promotes TSC2-null tumor growth.; Endocrine-related cancer. 2020 Feb 01. Ahmed MThirunavukkarasu SRosa BAThomas KADas SRangel-Moreno JLu LMehra SMbandi SKThackray LBDiamond MSMurphy KMMeans TMartin JKaushal DScriba TJMitreva MKhader SA Immune correlates of tuberculosis disease and risk translate across species.; Science translational medicine; Vol 12(528). 2020 Jan 29. Hwang JYSilva-Sanchez ACarragher DMGarcia-Hernandez MLRangel-Moreno JRandall TD Inducible Bronchus-Associated Lymphoid Tissue (iBALT) Attenuates Pulmonary Pathology in a Mouse Model of Allergic Airway Disease.; Frontiers in immunology; Vol 11. 2020. Dunlap MDPrince OARangel-Moreno JThomas KAScordo JMTorrelles JBCox JSteyn AJCZúñiga JKaushal DKhader SA Formation of Lung Inducible Bronchus Associated Lymphoid Tissue Is Regulated by Mycobacterium tuberculosis Expressed Determinants.; Frontiers in immunology; Vol 11. 2020. Alberto Choreño-Parra JBobba SRangel-Moreno JAhmed MMehra SRosa BMartin JMitreva MKaushal DZúñiga JKhader SA Mycobacterium tuberculosis HN878 infection induces human-like B cell follicles in mice.; The Journal of infectious diseases. 2019 Dec 13. Chiem KRangel-Moreno JNogales AMartinez-Sobrido L A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection.; Journal of visualized experiments : JoVE. 2019 Aug 14. Ardain ADomingo-Gonzalez RDas SKazer SWHoward NCSingh AAhmed MNhamoyebonde SRangel-Moreno JOgongo PLu LRamsuran Dde la Luz Garcia-Hernandez MUlland TKDarby MPark EKarim FMelocchi LMadansein RDullabh KJDunlap MMarin-Agudelo NEbihara TNdung'u TKaushal DPym ASKolls JKSteyn AZúñiga JHorsnell WYokoyama WMShalek AKKløverpris HNColonna MLeslie AKhader SA Publisher Correction: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis.; Nature. 2019 Jul 24. Ardain ADomingo-Gonzalez RDas SKazer SWHoward NCSingh AAhmed MNhamoyebonde SRangel-Moreno JOgongo PLu LRamsuran Dde la Luz Garcia-Hernandez MK Ulland TDarby MPark EKarim FMelocchi LMadansein RDullabh KJDunlap MMarin-Agudelo NEbihara TNdung'u TKaushal DPym ASKolls JKSteyn AZúñiga JHorsnell WYokoyama WMShalek AKKløverpris HNColonna MLeslie AKhader SA Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis.; Nature. 2019 Jun 05. Atif SMMack DGMcKee ASRangel-Moreno JMartin AKGetahun AMaier LACambier JCTuder RFontenot AP Protective role of B cells in sterile particulate-induced lung injury.; JCI insight; Vol 5. 2019 May 16. Zhang FWei KSlowikowski KFonseka CYRao DAKelly SGoodman SMTabechian DHughes LBSalomon-Escoto KWatts GFMJonsson AHRangel-Moreno JMeednu NRozo CApruzzese WEisenhaure TMLieb DJBoyle DLMandelin AMBoyce BFDiCarlo EGravallese EMGregersen PKMoreland LFirestein GSHacohen NNusbaum CLederer JAPerlman HPitzalis CFiler AHolers VMBykerk VPDonlin LTAnolik JHBrenner MBRaychaudhuri S Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.; Nature immunology. 2019 May 06.