Publications

• 1. Franchini L
  2. Porter JJ
  3. Lueck JD
  4. Orlandi C
  Gz Enhanced Signal Transduction assaY (G Z ESTY) for GPCR deorphanization.; bioRxiv : the preprint server for biology. 2024 Jul 26.
• 1. Franchini L
  2. Orlandi C
  Deorphanization of G Protein Coupled Receptors (GPCRs): a historical perspective.; Molecular pharmacology. 2024 Apr 15.
• 1. Alabdali R
  2. Franchini L
  3. Orlandi C
  Gα protein signaling bias at 5-HT1A receptor.; Molecular pharmacology. 2023 Aug 11.
• 1. Franchini L
  2. Orlandi C
  Probing the orphan receptors: Tools and directions.; Progress in molecular biology and translational science; Vol 195, pp. 47-76. 2022 Jul 13.
• 1. Fu W
  2. Franchini L
  3. Orlandi C
  Comprehensive Spatial Profile of the Orphan G Protein Coupled Receptor GPRC5B Expression in Mouse Brain.; Frontiers in neuroscience; Vol 16, pp. 891544. 2022 Jun 23.
• 1. Watkins LR
  2. Orlandi C
  In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity.; British journal of pharmacology. 2021 Mar 30.
• 1. Cao Y
  2. Wang Y
  3. Dunn HA
  4. Orlandi C
  5. Shultz N
  6. Kamasawa N
  7. Fitzpatrick D
  8. Li W
  9. Zeitz C
  10. Hauswirth W
  11. Martemyanov KA
  Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors.; Proceedings of the National Academy of Sciences of the United States of America. 2020 Sep 02.
• 1. Watkins LR
  2. Orlandi C
  Orphan G Protein Coupled Receptors in Affective Disorders.; Genes; Vol 11(6). 2020 Jun 24.
• 1. Sutton LP
  2. Muntean BS
  3. Ostrovskaya O
  4. Zucca S
  5. Dao M
  6. Orlandi C
  7. Song C
  8. Xie K
  9. Martemyanov KA
  NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control.; PLoS biology; Vol 17(10). 2019 Oct.
• 1. Wang D
  2. Stoveken HM
  3. Zucca S
  4. Dao M
  5. Orlandi C
  6. Song C
  7. Masuho I
  8. Johnston C
  9. Opperman KJ
  10. Giles AC
  11. Gill MS
  12. Lundquist EA
  13. Grill B
  14. Martemyanov KA
  Genetic behavioral screen identifies an orphan anti-opioid system.; Science (New York, N.Y.); Vol 365(6459). 2019 Sep 20.
• 1. Dunn HA
  2. Zucca S
  3. Dao M
  4. Orlandi C
  5. Martemyanov KA
  ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior.; Molecular psychiatry. 2019 Sep 04.
• 1. Song C
  2. Orlandi C
  3. Sutton LP
  4. Martemyanov KA
  The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex.; The Journal of biological chemistry; Vol 294(35). 2019 Aug 30.
• 1. Orlandi C
  2. Sutton LP
  3. Muntean BS
  4. Song C
  5. Martemyanov KA
  Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors.; Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology; Vol 44(3). 2019 Feb.
• 1. Dunn HA
  2. Orlandi C
  3. Martemyanov KA
  Beyond the Ligand: Extracellular and Transcellular G Protein-Coupled Receptor Complexes in Physiology and Pharmacology.; Pharmacological reviews; Vol 71(4). 2019 Jan.
• 1. Dunn HA
  2. Patil DN
  3. Cao Y
  4. Orlandi C
  5. Martemyanov KA
  Synaptic adhesion protein ELFN1 is a selective allosteric modulator of group III metabotropic glutamate receptors in trans.; Proceedings of the National Academy of Sciences of the United States of America; Vol 115(19). 2018 May 08.
• 1. Sarria I
  2. Cao Y
  3. Wang Y
  4. Ingram NT
  5. Orlandi C
  6. Kamasawa N
  7. Kolesnikov AV
  8. Pahlberg J
  9. Kefalov VJ
  10. Sampath AP
  11. Martemyanov KA
  LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone Photoreceptors.; Cell reports; Vol 22(13). 2018 Mar 27.
• 1. Sutton LP
  2. Orlandi C
  3. Song C
  4. Oh WC
  5. Muntean BS
  6. Xie K
  7. Filippini A
  8. Xie X
  9. Satterfield R
  10. Yaeger JDW
  11. Renner KJ
  12. Young SM
  13. Xu B
  14. Kwon H
  15. Martemyanov KA
  Orphan receptor GPR158 controls stress-induced depression.; eLife; Vol 7. 2018 Feb 08.
• 1. Ostrovskaya OI
  2. Orlandi C
  3. Fajardo-Serrano A
  4. Young SM
  5. Lujan R
  6. Martemyanov KA
  Inhibitory Signaling to Ion Channels in Hippocampal Neurons Is Differentially Regulated by Alternative Macromolecular Complexes of RGS7.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 38(46). 2018 Jan 14.
• 1. Condomitti G
  2. Wierda KD
  3. Schroeder A
  4. Rubio SE
  5. Vennekens KM
  6. Orlandi C
  7. Martemyanov KA
  8. Gounko NV
  9. Savas JN
  10. de Wit J
  An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses.; Neuron; Vol 100(1). 2018 Jan 10.
• 1. Orlandi C
  2. Omori Y
  3. Wang Y
  4. Cao Y
  5. Ueno A
  6. Roux MJ
  7. Condomitti G
  8. de Wit J
  9. Kanagawa M
  10. Furukawa T
  11. Martemyanov KA
  Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors.; Cell reports; Vol 25(1). 2018 Jan 02.
• 1. Sutton LP
  2. Ostrovskaya O
  3. Dao M
  4. Xie K
  5. Orlandi C
  6. Smith R
  7. Wee S
  8. Martemyanov KA
  Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum.; Biological psychiatry; Vol 80(3). 2016 Aug 01.
• 1. Tayou J
  2. Wang Q
  3. Jang GF
  4. Pronin AN
  5. Orlandi C
  6. Martemyanov KA
  7. Crabb JW
  8. Slepak VZ
  Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by Gαo and R7-binding Protein.; The Journal of biological chemistry; Vol 291(17). 2016 Apr 22.
• 1. Sarria I
  2. Orlandi C
  3. McCall MA
  4. Gregg RG
  5. Martemyanov KA
  Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 36(10). 2016 Mar 09.
• 1. Xu Y
  2. Orlandi C
  3. Cao Y
  4. Yang S
  5. Choi CI
  6. Pagadala V
  7. Birnbaumer L
  8. Martemyanov KA
  9. Vardi N
  The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go.; Scientific reports; Vol 6. 2016 Feb 17.
• 1. Xie K
  2. Colgan LA
  3. Dao MT
  4. Muntean BS
  5. Sutton LP
  6. Orlandi C
  7. Boye SL
  8. Boye SE
  9. Shih CC
  10. Li Y
  11. Xu B
  12. Smith RG
  13. Yasuda R
  14. Martemyanov KA
  NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum.; Current biology : CB; Vol 26(22). 2016 Jan 21.
• 1. Aguado C
  2. Orlandi C
  3. Fajardo-Serrano A
  4. Gil-Minguez M
  5. Martemyanov KA
  6. Luján R
  Cellular and Subcellular Localization of the RGS7/Gβ5/R7BP Complex in the Cerebellar Cortex.; Frontiers in neuroanatomy; Vol 10. 2016.
• 1. Cao Y
  2. Sarria I
  3. Fehlhaber KE
  4. Kamasawa N
  5. Orlandi C
  6. James KN
  7. Hazen JL
  8. Gardner MR
  9. Farzan M
  10. Lee A
  11. Baker S
  12. Baldwin K
  13. Sampath AP
  14. Martemyanov KA
  Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision.; Neuron; Vol 87(6). 2015 Sep 23.
• 1. Orlandi C
  2. Xie K
  3. Masuho I
  4. Fajardo-Serrano A
  5. Lujan R
  6. Martemyanov KA
  Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain.; The Journal of biological chemistry; Vol 290(22). 2015 May 29.
• 1. Orlandi C
  2. Cao Y
  3. Martemyanov KA
  Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons.; Investigative ophthalmology & visual science; Vol 54(10). 2013 Oct 29.
• 1. La Via L
  2. Bonini D
  3. Russo I
  4. Orlandi C
  5. Barlati S
  6. Barbon A
  Modulation of dendritic AMPA receptor mRNA trafficking by RNA splicing and editing.; Nucleic acids research; Vol 41(1). 2013 Jan 07.
• 1. Orlandi C
  2. Posokhova E
  3. Masuho I
  4. Ray TA
  5. Hasan N
  6. Gregg RG
  7. Martemyanov KA
  GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes.; The Journal of cell biology; Vol 197(6). 2012 Jun 11.
• 1. Orlandi C
  2. Barbon A
  3. Barlati S
  Activity regulation of adenosine deaminases acting on RNA (ADARs).; Molecular neurobiology; Vol 45(1). 2012 Feb.
• 1. Barbon A
  2. Caracciolo L
  3. Orlandi C
  4. Musazzi L
  5. Mallei A
  6. La Via L
  7. Bonini D
  8. Mora C
  9. Tardito D
  10. Gennarelli M
  11. Racagni G
  12. Popoli M
  13. Barlati S
  Chronic antidepressant treatments induce a time-dependent up-regulation of AMPA receptor subunit protein levels.; Neurochemistry international; Vol 59(6). 2011 Nov.
• 1. Barbon A
  2. Orlandi C
  3. La Via L
  4. Caracciolo L
  5. Tardito D
  6. Musazzi L
  7. Mallei A
  8. Gennarelli M
  9. Racagni G
  10. Popoli M
  11. Barlati S
  Antidepressant treatments change 5-HT2C receptor mRNA expression in rat prefrontal/frontal cortex and hippocampus.; Neuropsychobiology; Vol 63(3). 2011.
• 1. Orlandi C
  2. La Via L
  3. Bonini D
  4. Mora C
  5. Russo I
  6. Barbon A
  7. Barlati S
  AMPA receptor regulation at the mRNA and protein level in rat primary cortical cultures.; PloS one; Vol 6(9). 2011.
• 1. Barbon A
  2. Gervasoni A
  3. LaVia L
  4. Orlandi C
  5. Jaskolski F
  6. Perrais D
  7. Barlati S
  Human GluR6c, a functional splicing variants of GluR6, is mainly expressed in non-nervous cells.; Neuroscience letters; Vol 434(1). 2008 Mar 21.