Publications

• 1. Thalalla Gamage S
  2. Khoogar R
  3. Howpay Manage S
  4. Crawford MC
  5. Georgeson J
  6. Polevoda BV
  7. Sanders C
  8. Lee KA
  9. Nance KD
  10. Iyer V
  11. Kustanovich A
  12. Perez M
  13. Thu CT
  14. Nance SR
  15. Amin R
  16. Miller CN
  17. Holewinski RJ
  18. Meyer T
  19. Koparde V
  20. Yang A
  21. Jailwala P
  22. Nguyen JT
  23. Andresson T
  24. Hunter K
  25. Gu S
  26. Mock BA
  27. Edmondson EF
  28. Difilippantonio S
  29. Chari R
  30. Schwartz S
  31. O'Connell MR
  32. Wu CC
  33. Meier JL
  Transfer RNA acetylation regulates in vivo mammalian stress signaling.; bioRxiv : the preprint server for biology. 2024 Jul 28.
• 1. Liu L
  2. Xu Z
  3. Molina Vargas AM
  4. Dollery SJ
  5. Schrlau MG
  6. Cormier D
  7. O'Connell MR
  8. Tobin GJ
  9. Du K
  Aerosol Jet Printing-Enabled Dual-Function Electrochemical and Colorimetric Biosensor for SARS-CoV-2 Detection.; Analytical chemistry. 2023 Jul 28.
• 1. Hollinger J
  2. Wu J
  3. Awayda KM
  4. O'Connell MR
  5. Yao P
  Expression and purification of the mitochondrial transmembrane protein FAM210A in Escherichia coli.; Protein expression and purification; Vol 210, pp. 106322. 2023 Jun 15.
• 1. VanderWal AR
  2. Park JU
  3. Polevoda B
  4. Nicosia JK
  5. Molina Vargas AM
  6. Kellogg EH
  7. O'Connell MR
  Csx28 is a membrane pore that enhances CRISPR-Cas13b-dependent antiphage defense.; Science (New York, N.Y.); Vol 380(6643), pp. 410-415. 2023 Apr 27.
• 1. Knott GJ
  2. Lapinaite A
  3. O'Connell MR
  Methods special issue: RNA-targeting technologies.; Methods (San Diego, Calif.); Vol 212, pp. 10-11. 2023 Feb 13.
• 1. Molina Vargas AM
  2. Sinha S
  3. Osborn R
  4. Arantes PR
  5. Patel A
  6. Dewhurst S
  7. Hardy DJ
  8. Cameron A
  9. Palermo G
  10. O'Connell MR
  New design strategies for ultra-specific CRISPR-Cas13a-based RNA detection with single-nucleotide mismatch sensitivity.; Nucleic acids research. 2023 Jan 30.
• 1. Sinha S
  2. Molina Vargas AM
  3. Arantes PR
  4. Patel A
  5. O'Connell MR
  6. Palermo G
  Unveiling the RNA-mediated allosteric activation discloses functional hotspots in CRISPR-Cas13a.; Nucleic acids research. 2023 Jan 30.
• 1. Joseph Davis Burris B
  2. Moises Molina Vargas A
  3. Park BJ
  4. O'Connell MR
  Optimization of specific RNA knockdown in mammalian cells with CRISPR-Cas13.; Methods (San Diego, Calif.). 2022 Aug 17.
• 1. Walker EJ
  2. Bettinger JQ
  3. Welle KA
  4. Hryhorenko JR
  5. Molina Vargas AM
  6. O'Connell MR
  7. Ghaemmaghami S
  Protein folding stabilities are a major determinant of oxidation rates for buried methionine residues.; The Journal of biological chemistry. 2022 Mar 25.
• 1. Broly M
  2. Polevoda BV
  3. Awayda KM
  4. Tong N
  5. Lentini J
  6. Besnard T
  7. Deb W
  8. O'Rourke D
  9. Baptista J
  10. Ellard S
  11. Almannai M
  12. Hashem M
  13. Abdulwahab F
  14. Shamseldin H
  15. Al-Tala S
  16. Alkuraya FS
  17. Leon A
  18. van Loon RLE
  19. Ferlini A
  20. Sanchini M
  21. Bigoni S
  22. Ciorba A
  23. van Bokhoven H
  24. Iqbal Z
  25. Al-Maawali A
  26. Al-Murshedi F
  27. Ganesh A
  28. Al-Mamari W
  29. Lim SC
  30. Pais LS
  31. Brown N
  32. Riazuddin S
  33. Bézieau S
  34. Fu D
  35. Isidor B
  36. Cogné B
  37. O'Connell MR
  THUMPD1 bi-allelic variants cause loss of tRNA acetylation and a syndromic neurodevelopmental disorder.; American journal of human genetics. 2022 Feb 11.
• 1. Waitkus J
  2. Chang Y
  3. Liu L
  4. Puttaswamy SV
  5. Chung T
  6. Vargas AMM
  7. Dollery SJ
  8. O'Connell MR
  9. Cai H
  10. Tobin GJ
  11. Bhalla N
  12. Du K
  Gold Nanoparticle Enabled Localized Surface Plasmon Resonance on Unique Gold Nanomushroom Structures for On-Chip CRISPR-Cas13a Sensing.; Advanced materials interfaces; Vol 10(1). 2022 Jan 27.
• 1. Liu L
  2. Xu Z
  3. Awayda K
  4. Dollery SJ
  5. Bao M
  6. Fan J
  7. Cormier D
  8. O'Connell M
  9. Tobin GJ
  10. Du K
  Gold Nanoparticle-Labeled CRISPR-Cas13a Assay for the Sensitive Solid-State Nanopore Molecular Counting.; Advanced materials technologies; Vol 7(3). 2022 Jan 22.
• 1. Davis BJ
  2. O'Connell MR
  Put on Your Para-spectacles: The Development of Optimized CRISPR-Cas13-Based Approaches to Image RNA Dynamics in Real Time.; Molecular cell; Vol 77(2). 2020 Jan 16.
• 1. Tambe A
  2. East-Seletsky A
  3. Knott GJ
  4. Doudna JA
  5. O'Connell MR
  RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a.; Cell reports; Vol 24(4). 2018 Jul 24.
• 1. O'Connell M
  Molecular Mechanisms of RNA-Targeting by Cas13-containing Type VI CRISPR-Cas Systems.; Journal of molecular biology. 2018 Jun 22.
• 1. De Franco S
  2. O'Connell MR
  3. Vandevenne M
  Engineering RNA-Binding Proteins by Modular Assembly of RanBP2-Type Zinc Fingers.; Methods in molecular biology (Clifton, N.J.); Vol 1867. 2018.
• 1. Knott GJ
  2. East-Seletsky A
  3. Cofsky JC
  4. Holton JM
  5. Charles E
  6. O'Connell MR
  7. Doudna JA
  Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.; Nature structural & molecular biology; Vol 24(10). 2017 Oct.
• 1. East-Seletsky A
  2. O'Connell MR
  3. Burstein D
  4. Knott GJ
  5. Doudna JA
  RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes.; Molecular cell; Vol 66(3). 2017 May 04.
• 1. East-Seletsky A
  2. O'Connell MR
  3. Knight SC
  4. Burstein D
  5. Cate JH
  6. Tjian R
  7. Doudna JA
  Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection.; Nature; Vol 538(7624). 2016 Oct 13.
• 1. Nelles DA
  2. Fang MY
  3. O'Connell MR
  4. Xu JL
  5. Markmiller SJ
  6. Doudna JA
  7. Yeo GW
  Programmable RNA Tracking in Live Cells with CRISPR/Cas9.; Cell; Vol 165(2). 2016 Apr 07.
• 1. Ma E
  2. Harrington LB
  3. O'Connell MR
  4. Zhou K
  5. Doudna JA
  Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes.; Molecular cell; Vol 60(3). 2015 Nov 05.
• 1. O'Connell MR
  2. Oakes BL
  3. Sternberg SH
  4. East-Seletsky A
  5. Kaplan M
  6. Doudna JA
  Programmable RNA recognition and cleavage by CRISPR/Cas9.; Nature; Vol 516(7530). 2014 Dec 11.
• 1. Vandevenne M
  2. O'Connell MR
  3. Helder S
  4. Shepherd NE
  5. Matthews JM
  6. Kwan AH
  7. Segal DJ
  8. Mackay JP
  Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA.; Angewandte Chemie (International ed. in English); Vol 53(30). 2014 Jul 21.
• 1. Clifton MK
  2. Westman BJ
  3. Thong SY
  4. O'Connell MR
  5. Webster MW
  6. Shepherd NE
  7. Quinlan KG
  8. Crossley M
  9. Blobel GA
  10. Mackay JP
  The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins.; PloS one; Vol 9(8). 2014.
• 1. Gamsjaeger R
  2. O'Connell MR
  3. Cubeddu L
  4. Shepherd NE
  5. Lowry JA
  6. Kwan AH
  7. Vandevenne M
  8. Swanton MK
  9. Matthews JM
  10. Mackay JP
  A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers.; The Journal of biological chemistry; Vol 288(49). 2013 Dec 06.
• 1. Bendak K
  2. Loughlin FE
  3. Cheung V
  4. O'Connell MR
  5. Crossley M
  6. Mackay JP
  A rapid method for assessing the RNA-binding potential of a protein.; Nucleic acids research; Vol 40(14). 2012 Aug.
• 1. O'Connell MR
  2. Vandevenne M
  3. Nguyen CD
  4. Matthews JM
  5. Gamsjaeger R
  6. Segal DJ
  7. Mackay JP
  Modular assembly of RanBP2-type zinc finger domains to target single-stranded RNA.; Angewandte Chemie (International ed. in English); Vol 51(22). 2012 May 29.
• 1. Burdach J
  2. O'Connell MR
  3. Mackay JP
  4. Crossley M
  Two-timing zinc finger transcription factors liaising with RNA.; Trends in biochemical sciences; Vol 37(5). 2012 May.
• 1. Hsieh YS
  2. Wilkinson BL
  3. O'Connell MR
  4. Mackay JP
  5. Matthews JM
  6. Payne RJ
  Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants.; Organic letters; Vol 14(7). 2012 Apr 06.
• 1. O'Connell MR
  2. Gamsjaeger R
  3. Mackay JP
  The structural analysis of protein-protein interactions by NMR spectroscopy.; Proteomics; Vol 9(23). 2009 Dec.