Recent Publications

• 1. Rambout X
  2. Maquat LE
  Nuclear mRNA decay: regulatory networks that control gene expression.; Nature reviews. Genetics. 2024 Apr 18.
• 1. Alessandrini F
  2. Wright M
  3. Kurosaki T
  4. Maquat LE
  5. Kiskinis E
  ALS-Associated TDP-43 Dysfunction Compromises UPF1-Dependent mRNA Metabolism Pathways Including Alternative Polyadenylation and 3'UTR Length.; bioRxiv : the preprint server for biology. 2024 Feb 02.
• 1. Kurosaki T
  2. Rambout X
  3. Maquat LE
  FMRP-mediated spatial regulation of physiologic NMD targets in neuronal cells.; Genome biology; Vol 25(1), pp. 31. 2024 Jan 23.
• 1. Rambout X
  2. Cho H
  3. Blanc R
  4. Lyu Q
  5. Miano JM
  6. Chakkalakal JV
  7. Nelson GM
  8. Yalamanchili HK
  9. Adelman K
  10. Maquat LE
  PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII.; Molecular cell; Vol 83(2), pp. 186-202.e11. 2023 Jan 19.
• 1. Cho H
  2. Abshire ET
  3. Popp MW
  4. Pröschel C
  5. Schwartz JL
  6. Yeo GW
  7. Maquat LE
  AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay.; Molecular cell. 2022 Jun 03.
• 1. Maquat L
  2. Johnson R
  3. Valadkhan S
  4. Carninci P
  Lessons from the functional characterization of lncRNAs: introduction to mammalian genome special issue.; Mammalian genome : official journal of the International Mammalian Genome Society. 2022 May 09.
• 1. Kurosaki T
  2. Mitsutomi S
  3. Hewko A
  4. Akimitsu N
  5. Maquat LE
  Integrative omics indicate FMRP sequesters mRNA from translation and deadenylation in human neuronal cells.; Molecular cell. 2022 Jan 01.
• 1. Cable J
  2. Heard E
  3. Hirose T
  4. Prasanth KV
  5. Chen LL
  6. Henninger JE
  7. Quinodoz SA
  8. Spector DL
  9. Diermeier SD
  10. Porman AM
  11. Kumar D
  12. Feinberg MW
  13. Shen X
  14. Unfried JP
  15. Johnson R
  16. Chen CK
  17. Wilusz JE
  18. Lempradl A
  19. McGeary SE
  20. Wahba L
  21. Pyle AM
  22. Hargrove AE
  23. Simon MD
  24. Marcia M
  25. Przanowska RK
  26. Chang HY
  27. Jaffrey SR
  28. Contreras LM
  29. Chen Q
  30. Shi J
  31. Mendell JT
  32. He L
  33. Song E
  34. Rinn JL
  35. Lalwani MK
  36. Kalem MC
  37. Chuong EB
  38. Maquat LE
  39. Liu X
  Noncoding RNAs: biology and applications-a Keystone Symposia report.; Annals of the New York Academy of Sciences. 2021 Nov 17.
• 1. Kurosaki T
  2. Sakano H
  3. Pröschel C
  4. Wheeler J
  5. Hewko A
  6. Maquat LE
  NMD abnormalities during brain development in the Fmr1-knockout mouse model of fragile X syndrome.; Genome biology; Vol 22(1). 2021 Nov 16.
• 1. Kurosaki T
  2. Imamachi N
  3. Pröschel C
  4. Mitsutomi S
  5. Nagao R
  6. Akimitsu N
  7. Maquat LE
  Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay.; Nature cell biology; Vol 23(1). 2021 Jan.
• 1. Rambout X
  2. Maquat LE
  NCBP3: A Multifaceted Adaptive Regulator of Gene Expression.; Trends in biochemical sciences. 2020 Oct 05.
• 1. Rambout X
  2. Maquat LE
  The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing.; Genes & development; Vol 34(17-18). 2020 Sep 01.
• 1. Zheng D
  2. Cho H
  3. Wang W
  4. Rambout X
  5. Tian B
  6. Maquat LE
  3'READS+RIP defines differential Staufen1 binding to alternative 3'UTR isoforms and reveals structures and sequence motifs influencing binding and polysome association.; RNA (New York, N.Y.). 2020 Aug 12.
• 1. Popp MW
  2. Cho H
  3. Maquat LE
  Viral subversion of nonsense-mediated mRNA decay.; RNA (New York, N.Y.). 2020 Jul 22.
• 1. Rambout X
  2. Cho H
  3. Maquat LE
  Transcriptional Coactivator PGC-1α Binding to Newly Synthesized RNA via CBP80: A Nexus for Co- and Posttranscriptional Gene Regulation.; Cold Spring Harbor symposia on quantitative biology. 2020 Apr 15.
• 1. Maquat LE
  Short interspersed nuclear element (SINE)-mediated post-transcriptional effects on human and mouse gene expression: SINE-UP for active duty.; Philosophical transactions of the Royal Society of London. Series B, Biological sciences; Vol 375(1795). 2020 Mar 30.
• 1. Kurosaki T
  2. Popp MW
  3. Maquat LE
  Publisher Correction: Quality and quantity control of gene expression by nonsense-mediated mRNA decay.; Nature reviews. Molecular cell biology; Vol 20(6). 2019 Jun.
• 1. Kurosaki T
  2. Popp MW
  3. Maquat LE
  Quality and quantity control of gene expression by nonsense-mediated mRNA decay.; Nature reviews. Molecular cell biology. 2019 Apr 16.
• 1. Kim YK
  2. Maquat LE
  UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond.; RNA (New York, N.Y.); Vol 25(4). 2019 Apr.
• 1. Kurosaki T
  2. Myers JR
  3. Maquat LE
  Defining nonsense-mediated mRNA decay intermediates in human cells.; Methods (San Diego, Calif.); Vol 155. 2019 Feb 15.
• 1. Wolin SL
  2. Maquat LE
  Cellular RNA surveillance in health and disease.; Science (New York, N.Y.); Vol 366(6467). 2019 Jan 15.
• 1. Kurosaki T
  2. Myers JA
  3. Maquat LE
  Defining nonsense-mediated mRNA decay intermediates in human cells.; Methods: Biochemical and next generation sequencing approaches to study RNA regulation.. 2019 Jan 01.
• 1. Elbarbary RA
  2. Maquat LE
  Evaluating the susceptibility of AGO2-loaded microRNAs to degradation by nucleases in vitro.; Methods: MicroRNA biogenesis, identification, function and decay.; Vol 152, pp. 18-22. 2019 Jan 01.
• 1. Kurosaki T
  2. Miyoshi K
  3. Myers JR
  4. Maquat LE
  Publisher Correction: NMD-degradome sequencing reveals ribosome-bound intermediates with 3'-end non-templated nucleotides.; Nature structural & molecular biology; Vol 25(11). 2018 Nov.
• 1. Kurosaki T
  2. Miyoshi K
  3. Myers JR
  4. Maquat LE
  NMD-degradome sequencing reveals ribosome-bound intermediates with 3'-end non-templated nucleotides.; Nature structural & molecular biology; Vol 25(10). 2018 Oct.
• 1. Elbarbary R
  2. Maquat LE
  Evaluating the susceptibility of AGO2-loaded microRNAs to degradation by nucleases in vitro.; Methods (San Diego, Calif.). 2018 May 16.
• 1. Walter NG
  2. Maquat LE
  Introduction-RNA: From Single Molecules to Medicine.; Chemical reviews; Vol 118(8). 2018 Apr 25.
• 1. Kurosaki T
  2. Maquat LE
  Molecular autopsy provides evidence for widespread ribosome-phased mRNA fragmentation.; Nature structural & molecular biology; Vol 25(4). 2018 Apr.
• 1. Cho H
  2. Rambout X
  3. Gleghorn ML
  4. Nguyen PQT
  5. Phipps CR
  6. Miyoshi K
  7. Myers JR
  8. Kataoka N
  9. Fasan R
  10. Maquat LE
  Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression.; Genes & development; Vol 32(7-8). 2018 Apr 01.
• 1. Lucas BA
  2. Lavi E
  3. Shiue L
  4. Cho H
  5. Katzman S
  6. Miyoshi K
  7. Siomi MC
  8. Carmel L
  9. Ares M
  10. Maquat LE
  Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay.; Proceedings of the National Academy of Sciences of the United States of America. 2018 Jan 16.
• 1. Kurosaki T
  2. Hoque M
  3. Maquat LE
  Identifying Cellular Nonsense-Mediated mRNA Decay (NMD) Targets: Immunoprecipitation of Phosphorylated UPF1 Followed by RNA Sequencing (p-UPF1 RIP-Seq).; Methods in molecular biology (Clifton, N.J.); Vol 1720. 2018.
• 1. Rambout X
  2. Dequiedt F
  3. Maquat LE
  Beyond Transcription: Roles of Transcription Factors in Pre-mRNA Splicing.; Chemical reviews. 2017 Dec 18.
• 1. Popp MW
  2. Maquat LE
  Nonsense-mediated mRNA Decay and Cancer.; Current opinion in genetics & development; Vol 48. 2017 Nov 07.
• 1. Elbarbary RA
  2. Miyoshi K
  3. Hedaya O
  4. Myers JR
  5. Maquat LE
  UPF1 helicase promotes TSN-mediated miRNA decay.; Genes & development; Vol 31(14). 2017 Jul 15.
• 1. Elbarbary RA
  2. Maquat LE
  Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism.; Nature structural & molecular biology; Vol 24(6). 2017 Jun 06.
• 1. Elbarbary RA
  2. Miyoshi K
  3. Myers JR
  4. Du P
  5. Ashton JM
  6. Tian B
  7. Maquat LE
  Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition.; Science (New York, N.Y.); Vol 356(6340). 2017 May 26.
• 1. Gleghorn ML
  2. Zhao J
  3. Turner DH
  4. Maquat LE
  Crystal structure of a poly(rA) staggered zipper at acidic pH: evidence that adenine N1 protonation mediates parallel double helix formation.; Nucleic acids research. 2016 Jun 10.
• 1. Popp MW
  2. Maquat LE
  Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine.; Cell; Vol 165(6). 2016 Jun 2.
• 1. Maquat LE
  Eukaryotic antisense ahead of its time.; Nature reviews. Molecular cell biology; Vol 17(4). 2016 Apr.
• 1. Elbarbary RA
  2. Maquat LE
  Coupling pre-mRNA splicing and 3' end formation to mRNA export: alternative ways to punch the nuclear export clock.; Genes & development; Vol 30(5). 2016 Mar 1.
• 1. Elbarbary RA
  2. Lucas BA
  3. Maquat LE
  Retrotransposons as regulators of gene expression.; Science (New York, N.Y.); Vol 351(6274). 2016 Feb 12.
• 1. Kurosaki T
  2. Maquat LE
  Nonsense-mediated mRNA decay in humans at a glance.; Journal of cell science; Vol 129(3). 2016 Feb 1.
• 1. Maquat LE
  The amazing web of post-transcriptional gene control: the sum of small changes can make for significant consequences.; RNA (New York, N.Y.); Vol 21(4). 2015 Apr.
• 1. Elbarbary RA
  2. Maquat LE
  CARMing down the SINEs of anarchy: two paths to freedom from paraspeckle detention.; Genes & development; Vol 29(7). 2015 Apr 1.
• 1. Popp MW
  2. Maquat LE
  RNA. A TRICK'n way to see the pioneer round of translation.; Science (New York, N.Y.); Vol 347(6228). 2015 Mar 20.
• 1. Popp MW
  2. Maquat LE
  Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics.; Nature communications; Vol 6. 2015.
• 1. Gong C
  2. Maquat LE
  Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells.; Methods in molecular biology (Clifton, N.J.); Vol 1206. 2015.
• 1. Jackson KL
  2. Dayton RD
  3. Orchard EA
  4. Ju S
  5. Ringe D
  6. Petsko GA
  7. Maquat LE
  8. Klein RL
  Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis.; Gene therapy; Vol 22(1). 2015 Jan.
• 1. Kurosaki T
  2. Li W
  3. Hoque M
  4. Popp MW
  5. Ermolenko DN
  6. Tian B
  7. Maquat LE
  A post-translational regulatory switch on UPF1 controls targeted mRNA degradation.; Genes & development; Vol 28(17). 2014 Sep 1.
• 1. Gleghorn ML
  2. Maquat LE
  'Black sheep' that don't leave the double-stranded RNA-binding domain fold.; Trends in biochemical sciences; Vol 39(7). 2014 Jul.