URMC / Labs / Lord Lab / Publications Publications Hughson ALHannon GSalama NAVrooman TGStockwell CAMills BNGarrett-Larsen JQiu HKaterji RBenoodt LJohnston CJMurphy JDKruger EYe JGavras NWKeeley DCQin SSLesch MLMuhitch JBLove TMTCalvi LMLord EMLuheshi NElyes JLinehan DCGerber SA Integrating IL-12 mRNA nanotechnology with SBRT eliminates T cell exhaustion in preclinical models of pancreatic cancer.; Molecular therapy. Nucleic acids; Vol 35(4), pp. 102350. 2024 Sep 30. Uccello TPLesch MLKintzel SAGradzewicz LBLamrous LMurphy SPFleming FJMills BNMurphy JDHughson AHannon GGarrett-Larsen JQiu HDrage MGYe JGavras NWKeeley DCLove TMTRepasky EALord EMLinehan DCGerber SA New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy.; Cell death & disease; Vol 14(7), pp. 470. 2023 Jul 26. Ye JGavras NWKeeley DCHughson ALHannon GVrooman TGLesch MLJohnston CJLord EMBelt BALinehan DCEyles JGerber SA CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models.; Journal for immunotherapy of cancer; Vol 11(5). 2023 May. Battaglia NGMurphy JDUccello TPHughson AGavras NWCaldon JJGerber SALord EM Combination of NKG2A and PD-1 Blockade Improves Radiotherapy Response in Radioresistant Tumors.; Journal of immunology (Baltimore, Md. : 1950). 2022 Jul 15. Ye JMills BNQin SSGarrett-Larsen JMurphy JDUccello TPHan BJVrooman TGJohnston CJLord EMBelt BALinehan DCGerber SA Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer.; Journal for immunotherapy of cancer; Vol 10(7). 2022 Jul. Ortiz-Bonilla CJUccello TPGerber SALord EMMessing EMLee YF Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity.; International journal of molecular sciences; Vol 23(6). 2022 Mar 08. Uccello TPKintzel SAMills BNMurphy JDGarrett-Larsen JBattaglia NGRodriguez CJDrage MGYe JLove TMTJohnston CJRepasky EAQiu HLinehan DCLord EMGerber SA Development of an Orthotopic Murine Model of Rectal Cancer in Conjunction With Targeted Short-Course Radiation Therapy.; Advances in radiation oncology; Vol 7(2). 2022 Mar. Uccello TPLecsh MLUllman NAKintzel SAGradzewicz LBVelagaleti TFleming FJMills BNMurphy JDGarrett-Larsen JQiu HDrage MGYe JGavras NWJohnston CJLove TMTRepasky EALinehan DCLord EMGerber SA Radiotherapy exacerbates tumor-promoting innervation and nerve signaling in rectal cancer.; International journal of radiation oncology, biology, physics. 2022 Jan 03. Qin SSHan BJWilliams AJackson KMJewell RChacon ACLord EMLinehan DCKim MReuben AGerber SAPrieto PA Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model.; Cancers; Vol 13(10). 2021 May 11. Battaglia NGUccello TPHughson AGarrett-Larsen JCaldon JJQiu HGerber SALord EM Co-administration of a clinically relevant dexamethasone dosage with ablative radiotherapy reduces peripheral lymphocytes but does not alter in vivo intratumoral lymphocyte phenotype or inhibit efficacy of radiotherapy in a murine colorectal tumor model.; International journal of radiation oncology, biology, physics. 2021 Apr 29. Han BJMurphy JDQin SYe JUccello TPGarrett-Larsen JBelt BAPrieto PAEgilmez NKLord EMLinehan DCMills BNGerber SA Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma.; Immunological investigations. 2020 Jun 04. Ye JMills BNZhao THan BJMurphy JDPatel APJohnston CJLord EMBelt BALinehan DCGerber SA Assessing the magnitude of immunogenic cell death following chemotherapy and irradiation reveals a new strategy to treat pancreatic cancer.; Cancer immunology research. 2019 Nov 12. Mills BNConnolly KAYe JMurphy JDUccello TPHan BJZhao TDrage MGMurthy AQiu HPatel AFigueroa NMJohnston CJPrieto PAEgilmez NKBelt BALord EMLinehan DCGerber SA Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment.; Cell reports; Vol 29(2). 2019 Oct 08. Murthy AGerber SAKoch CJLord EM Intratumoral Hypoxia Reduces IFN-γ-Mediated Immunity and MHC Class I Induction in a Preclinical Tumor Model.; ImmunoHorizons; Vol 3(4). 2019 Apr 29. MacDonald CRBucsek MJQiao GChen MEvans LGreenberg DJUccello TPBattaglia NGHylander BLSingh AKLord EMGerber SARepasky EA Adrenergic Receptor Signaling Regulates the Response of Tumors to Ionizing Radiation.; Radiation research. 2019 Apr 25. Connolly KABelt BAFigueroa NMMurthy APatel AKim MLord EMLinehan DCGerber SA Increasing the efficacy of radiotherapy by modulating the CCR2/CCR5 chemokine axes.; Oncotarget. 2016 Nov 11. Barlow MLCummings RJPentland APLove TMHaidaris CGRyan JLLord EMGerber SA Total-Body Irradiation Exacerbates Dissemination of Cutaneous Candida Albicans Infection.; Radiation research. 2016 Oct 6. Zozzaro-Smith PEBushway MEGerber SAHebert DPressman EKLord EMMiller RKMurphy SP Whole mount immunofluorescence analysis of placentas from normotensive versus preeclamptic pregnancies.; Placenta; Vol 36(11). 2015 Nov. Gerber SACummings RJJudge JLBarlow MLNanduri JJohnson DEPalis JPentland APLord EMRyan JL Interleukin-12 preserves the cutaneous physical and immunological barrier after radiation exposure.; Radiation research; Vol 183(1). 2015 Jan. Martin DKUckermann OBertram ALiebner CHendruschk SSitoci-Ficici KHSchackert GLord EMTemme AKirsch M Differential growth inhibition of cerebral metastases by anti-angiogenic compounds.; Anticancer research; Vol 34(7). 2014 Jul. Gerber SALim JYConnolly KASedlacek ALBarlow MLMurphy SPEgilmez NKLord EM Radio-responsive tumors exhibit greater intratumoral immune activity than nonresponsive tumors.; International journal of cancer; Vol 134(10). 2014 May 15. Bushway MEGerber SAFenton BMMiller RKLord EMMurphy SP Morphological and phenotypic analyses of the human placenta using whole mount immunofluorescence.; Biology of reproduction; Vol 90(5). 2014 May. Xu YHyun YMLim KLee HCummings RJGerber SABae SCho TYLord EMKim M Optogenetic control of chemokine receptor signal and T-cell migration.; Proceedings of the National Academy of Sciences of the United States of America; Vol 111(17). 2014 Apr 29. Lim JYGerber SAMurphy SPLord EM Type I interferons induced by radiation therapy mediate recruitment and effector function of CD8(+) T cells.; Cancer immunology, immunotherapy : CII; Vol 63(3). 2014 Mar. Majumder SSowden MPGerber SAThomas TChristie CKMohan AYin GLord EMBerk BCPang J G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation.; Arteriosclerosis, thrombosis, and vascular biology; Vol 34(2). 2014 Feb. Lim JYBrockstedt DGLord EMGerber SA Radiation therapy combined with Listeria monocytogenes-based cancer vaccine synergize to enhance tumor control in the B16 melanoma model.; Oncoimmunology; Vol 3. 2014. Sedlacek ALGerber SARandall TDvan Rooijen NFrelinger JGLord EM Generation of a dual-functioning antitumor immune response in the peritoneal cavity.; The American journal of pathology; Vol 183(4). 2013 Oct. Gerber SASedlacek ALCron KRMurphy SPFrelinger JGLord EM IFN-γ mediates the antitumor effects of radiation therapy in a murine colon tumor.; The American journal of pathology; Vol 182(6). 2013 Jun. Gerber SASorensen EWSedlacek ALLim JYSkrombolas DFrelinger JGLord EM Local expression of interleukin-2 by B16 melanoma cells results in decreased tumour growth and long-term tumour dormancy.; Immunology; Vol 138(3). 2013 Mar. Cummings RJGerber SAJudge JLRyan JLPentland APLord EM Exposure to ionizing radiation induces the migration of cutaneous dendritic cells by a CCR7-dependent mechanism.; Journal of immunology (Baltimore, Md. : 1950); Vol 189(9). 2012 Nov 01. Valentino MDAbdul-Alim CSMaben ZJSkrombolas DHensley LLKawula THDziejman MLord EMFrelinger JAFrelinger JG A broadly applicable approach to T cell epitope identification: application to improving tumor associated epitopes and identifying epitopes in complex pathogens.; Journal of immunological methods; Vol 373(1-2). 2011 Oct 28. Sorensen EWGerber SAFrelinger JGLord EM IL-12 suppresses vascular endothelial growth factor receptor 3 expression on tumor vessels by two distinct IFN-gamma-dependent mechanisms.; Journal of immunology (Baltimore, Md. : 1950); Vol 184(4). 2010 Feb 15. Lord EM Immunology at the university of Rochester.; Immunologic research; Vol 45(2-3). 2009 Dec. Sorensen EWGerber SASedlacek ALRybalko VYChan WMLord EM Omental immune aggregates and tumor metastasis within the peritoneal cavity.; Immunologic research; Vol 45(2-3). 2009 Dec. Cummings RJMitra SFoster THLord EM Migration of skin dendritic cells in response to ionizing radiation exposure.; Radiation research; Vol 171(6). 2009 Jun. Cummings RJMitra SLord EMFoster TH Antibody-labeled fluorescence imaging of dendritic cell populations in vivo.; Journal of biomedical optics; Vol 13(4). 2008 Jul. Lugade AASorensen EWGerber SAMoran JPFrelinger JGLord EM Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity.; Journal of immunology (Baltimore, Md. : 1950); Vol 180(5). 2008 Mar 1. Santos KSimon DAConway EBowers WJMitra SFoster THLugade ALord EMFederoff HJDewhurst SFrelinger JG Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors.; Human gene therapy; Vol 18(2). 2007 Feb. Ramanayake TSimon DAFrelinger JGLord EMRobert J In vivo study of T-cell responses to skin alloantigens in Xenopus using a novel whole-mount immunohistology method.; Transplantation; Vol 83(2). 2007 Jan 27. Gerber SARybalko VYBigelow CELugade AAFoster THFrelinger JGLord EM Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth.; The American journal of pathology; Vol 169(5). 2006 Nov. Lugade AAMoran JPGerber SARose RCFrelinger JGLord EM Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor.; Journal of immunology (Baltimore, Md. : 1950); Vol 174(12). 2005 Jun 15. Gerber SATurner MJLugade AAMoran JPFrelinger JGLord EM Characterization of a lymph node within the mouse prostate: Detailed analysis using whole mount histology.; The Prostate; Vol 63(2). 2005 May 1. Moran JPGerber SAMartin CAFrelinger JGLord EM Transfection of the genes for interleukin-12 into the K1735 melanoma and the EMT6 mammary sarcoma murine cell lines reveals distinct mechanisms of antitumor activity.; International journal of cancer; Vol 106(5). 2003 Sep 20. Gerber SAMoran JPFrelinger JGFrelinger JAFenton BMLord EM Mechanism of IL-12 mediated alterations in tumour blood vessel morphology: analysis using whole-tissue mounts.; British journal of cancer; Vol 88(9). 2003 May 6. Fisher TLNocera MWillis RATurner MJAbdul Alim CSBrown DMBourne PAdi Sant'Agnese PAMessing EMLord EMFrelinger JG Generation of monoclonal antibodies specific for human kallikrein 2 (hK2) using hK2-expressing tumors.; The Prostate; Vol 51(3). 2002 May 15. Willis RABowers WJTurner MJFisher TLAbdul-Alim CSHoward DFFederoff HJLord EMFrelinger JG Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice.; Human gene therapy; Vol 12(15). 2001 Oct 10. Turner MJAbdul-Alim CSWillis RAFisher TLLord EMFrelinger JG T-cell antigen discovery (T-CAD) assay: a novel technique for identifying T cell epitopes.; Journal of immunological methods; Vol 256(1-2). 2001 Oct 1. Fenton BMLord EMPaoni SF Intravascular HBO(2) saturations, perfusion and hypoxia in spontaneous and transplanted tumor models.; International journal of cancer; Vol 93(5). 2001 Sep 1. Brown DMFisher TLWei CFrelinger JGLord EM Tumours can act as adjuvants for humoral immunity.; Immunology; Vol 102(4). 2001 Apr. Fenton BMLord EMPaoni SF Effects of radiation on tumor intravascular oxygenation, vascular configuration, development of hypoxia, and clonogenic survival.; Radiation research; Vol 155(2). 2001 Feb. Lee JMoran JPFenton BMKoch CJFrelinger JGKeng PCLord EM Alteration of tumour response to radiation by interleukin-2 gene transfer.; British journal of cancer; Vol 82(4). 2000 Feb. Fenton BMLord EMPaoni SF Enhancement of tumor perfusion and oxygenation by carbogen and nicotinamide during single- and multifraction irradiation.; Radiation research; Vol 153(1). 2000 Jan. Storozynsky EWoodward JGFrelinger JGLord EM Interleukin-3 and granulocyte-macrophage colony-stimulating factor enhance the generation and function of dendritic cells.; Immunology; Vol 97(1). 1999 May. Fenton BMPaoni SFLee JKoch CJLord EM Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements.; British journal of cancer; Vol 79(3-4). 1999 Feb. Wei CCallahan BPTurner MJWillis RALord EMBarth RKFrelinger JG Regulation of human prostate-specific antigen gene expression in transgenic mice: evidence for an enhancer between the PSA and human glandular kallikrein-1 genes.; International journal of molecular medicine; Vol 2(4). 1998 Oct. Yeh KYMcAdam AJPulaski BAShastri NFrelinger JGLord EM IL-3 enhances both presentation of exogenous particulate antigen in association with class I major histocompatibility antigen and generation of primary tumor-specific cytolytic T lymphocytes.; Journal of immunology (Baltimore, Md. : 1950); Vol 160(12). 1998 Jun 15. Lord EMYeh KYMoran JAStorozynsky EFrelinger JG IL-3-mediated enhancement of particulate antigen presentation by macrophages.; Journal of immunotherapy (Hagerstown, Md. : 1997); Vol 21(3). 1998 May. Lord EMFrelinger JG Tumor immunotherapy: cytokines and antigen presentation.; Cancer immunology, immunotherapy : CII; Vol 46(2). 1998 Apr. Lee JFenton BMKoch CJFrelinger JGLord EM Interleukin 2 expression by tumor cells alters both the immune response and the tumor microenvironment.; Cancer research; Vol 58(7). 1998 Apr 1. Willis RAWei CTurner MJCallahan BPPugh AEBarth RKLord EMFrelinger JG A transgenic strategy for analyzing the regulatory regions of the human prostate-specific antigen gene: potential applications for the treatment of prostate cancer (Review).; International journal of molecular medicine; Vol 1(2). 1998 Feb. Fenton BMPaoni SFKoch CJLord EM Effect of local irradiation on tumor oxygenation, perfused vessel density, and development of hypoxia.; Advances in experimental medicine and biology; Vol 454. 1998. Yeh KYChen ZNasir AOhsuga YTakashima ALord EMGaspari AA Expression of B7-1 by Pam 212 squamous cell carcinoma enhances tumor cell interactions with dendritic epidermal cells but does not affect in vivo tumor growth.; The Journal of investigative dermatology; Vol 109(6). 1997 Dec. Wei CWillis RATilton BRLooney RJLord EMBarth RKFrelinger JG Tissue-specific expression of the human prostate-specific antigen gene in transgenic mice: implications for tolerance and immunotherapy.; Proceedings of the National Academy of Sciences of the United States of America; Vol 94(12). 1997 Jun 10. Koch CJLord EMShapiro IMClyman RIEvans SM Imaging hypoxia and blood flow in normal tissues.; Advances in experimental medicine and biology; Vol 428. 1997. Lee JSiemann DWKoch CJLord EM Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts.; International journal of cancer; Vol 67(3). 1996 Jul 29. Wei CStorozynsky EMcAdam AJYeh KYTilton BRWillis RABarth RKLooney RJLord EMFrelinger JG Expression of human prostate-specific antigen (PSA) in a mouse tumor cell line reduces tumorigenicity and elicits PSA-specific cytotoxic T lymphocytes.; Cancer immunology, immunotherapy : CII; Vol 42(6). 1996 Jul. Pulaski BAYeh KYShastri NMaltby KMPenney DPLord EMFrelinger JG Interleukin 3 enhances cytotoxic T lymphocyte development and class I major histocompatibility complex "re-presentation" of exogenous antigen by tumor-infiltrating antigen-presenting cells.; Proceedings of the National Academy of Sciences of the United States of America; Vol 93(8). 1996 Apr 16. Woods MLKoch CJLord EM Detection of individual hypoxic cells in multicellular spheroids by flow cytometry using the 2-nitroimidazole, EF5, and monoclonal antibodies.; International journal of radiation oncology, biology, physics; Vol 34(1). 1996 Jan 1. McAdam AJPulaski BAStorozynsky EYeh KYSickel JZFrelinger JGLord EM Analysis of the effect of cytokines (interleukins 2, 3, 4, and 6, granulocyte-monocyte colony-stimulating factor, and interferon-gamma) on generation of primary cytotoxic T lymphocytes against a weakly immunogenic tumor.; Cellular immunology; Vol 165(2). 1995 Oct 15. Yeh KYPulaski BAWoods MLMcAdam AJGaspari AAFrelinger JGLord EM B7-1 enhances natural killer cell-mediated cytotoxicity and inhibits tumor growth of a poorly immunogenic murine carcinoma.; Cellular immunology; Vol 165(2). 1995 Oct 15. McAdam AJPulaski BAHarkins SSHutter EKLord EMFrelinger JG Synergistic effects of co-expression of the TH1 cytokines IL-2 and IFN-gamma on generation of murine tumor-reactive cytotoxic cells.; International journal of cancer; Vol 61(5). 1995 May 29. McAdam AJFelcher AWoods MLPulaski BAHutter EKFrelinger JGLord EM Transfection of transforming growth factor-beta producing tumor EMT6 with interleukin-2 elicits tumor rejection and tumor reactive cytotoxic T-lymphocytes.; Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy; Vol 15(3). 1994 Apr. Woods MLMcAdam AJFrelinger JGLord EM Isolation and expansion of tumor-infiltrating lymphocytes.; BioTechniques; Vol 15(6). 1993 Dec. Lord EMHarwell LKoch CJ Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts.; Cancer research; Vol 53(23). 1993 Dec 1. McAdam AJYeh KYPulaski BAFrelinger JGLord EM Interleukin-3 inhibits the generation of nonspecific killers by interleukin-2.; Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy; Vol 14(4). 1993 Nov. Chen ZRosten SILord EMGaspari AA Murine Pam 212 cutaneous squamous cell carcinoma is nonimmunogenic in normal syngeneic hosts and resistant to immune effector mechanisms.; Regional immunology; Vol 5(5). 1993 Sep. Pulaski BAMcAdam AJHutter EKBiggar SLord EMFrelinger JG Interleukin 3 enhances development of tumor-reactive cytotoxic cells by a CD4-dependent mechanism.; Cancer research; Vol 53(9). 1993 May 1. McAdam AJBlieden TMFrelinger JGLord EM CD4-class II major histocompatibility complex interaction does not enhance killing by a class I-restricted CD4+CD8+ cytotoxic T cell clone.; European journal of immunology; Vol 22(9). 1992 Sep. Cerosaletti KMWoodward JGLord EMFrelinger JG Two regions of the H-2 Dd promoter are responsive to dimethylsulfoxide in line 1 cells by a mechanism distinct from IFN-gamma.; Journal of immunology (Baltimore, Md. : 1950); Vol 148(4). 1992 Feb 15. Blieden TMMcAdam AJFrelinger JGLord EM Mechanism of cytolytic T lymphocyte killing of a low class I-expressing tumor.; Journal of immunology (Baltimore, Md. : 1950); Vol 147(4). 1991 Aug 15. Blieden TMMcAdam AJForesman MDCerosaletti KMFrelinger JGLord EM Class-I MHC expression in the mouse lung carcinoma, line 1: a model for class-I inducible tumors.; International journal of cancer. Supplement = Journal international du cancer. Supplement; Vol 6. 1991. Cerosaletti KMBlieden TMHarwell LWWelsh KMFrelinger JGLord EM Alteration of the metastatic potential of line 1 lung carcinoma cells: opposite effects of class I antigen induction by interferons versus DMSO or gene transfection.; Cellular immunology; Vol 127(2). 1990 May. Wilson KMSiegal GLord EM Tumor necrosis factor-mediated cytotoxicity by tumor-associated macrophages.; Cellular immunology; Vol 123(1). 1989 Oct 1. Liu YCMarraccino RLKeng PCBambara RALord EMChou WGZain SB Requirement for proliferating cell nuclear antigen expression during stages of the Chinese hamster ovary cell cycle.; Biochemistry; Vol 28(7). 1989 Apr 4. Bahler DWCerosaletti KMLord EMFrelinger JG Molecular analysis of deficient class I H-2 antigen expression by mouse lung carcinoma cells.; Journal of immunology (Baltimore, Md. : 1950); Vol 140(11). 1988 Jun 1. Marraccino RLWahl AFKeng PCLord EMBambara RA Cell cycle dependent activities of DNA polymerases alpha and delta in Chinese hamster ovary cells.; Biochemistry; Vol 26(24). 1987 Dec 1. Loeffler DAKeng PCWilson KMLord EM Comparison of fluorescence intensity of Hoechst 33342-stained EMT6 tumour cells and tumour-infiltrating host cells.; British journal of cancer; Vol 56(5). 1987 Nov.