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Looney Lab

Therapeutic Targeting of Senescent Cells in Lupus

Targeting senescent cells in patients with lupus presents a potential novel approach to disease management and improved clinical outcomes.  While it is known that lupus patients possess cells with a senescence-like phenotype, it is unknown whether these cells would respond to available senolytic drugs.  Studying the effects of these drugs in vitro using patient and lupus mouse model samples will further fundamental insights into the potential role of senolytic drugs in the treatment of lupus.

Richard John Looney, M.D.

Richard John Looney, M.D.
Principal Investigator

Publications

    1. Bialic-Murphy L
    2. McElderry RM
    3. Esquivel-Muelbert A
    4. van den Hoogen J
    5. Zuidema PA
    6. Phillips OL
    7. de Oliveira EA
    8. Loayza PA
    9. Alvarez-Davila E
    10. Alves LF
    11. Maia VA
    12. Vieira SA
    13. Arantes da Silva LC
    14. Araujo-Murakami A
    15. Arets E
    16. Astigarraga J
    17. Baccaro F
    18. Baker T
    19. Banki O
    20. Barroso J
    21. Blanc L
    22. Bonal D
    23. Bongers F
    24. Bordin KM
    25. Brienen R
    26. de Medeiros MB
    27. Camargo JL
    28. Araújo FC
    29. Castilho CV
    30. Castro W
    31. Moscoso VC
    32. Comiskey J
    33. Costa F
    34. Müller SC
    35. de Almeida EC
    36. Lôla da Costa AC
    37. de Andrade Kamimura V
    38. de Oliveira F
    39. Del Aguila Pasquel J
    40. Derroire G
    41. Dexter K
    42. Di Fiore A
    43. Duchesne L
    44. Emílio T
    45. Farrapo CL
    46. Fauset S
    47. Draper FC
    48. Feldpausch TR
    49. Ramos RF
    50. Martins VF
    51. Simon MF
    52. Reis MG
    53. Manzatto AG
    54. Herault B
    55. Herrera R
    56. Coronado EH
    57. Howe R
    58. Huamantupa-Chuquimaco I
    59. Huasco WH
    60. Zanini KJ
    61. Joly C
    62. Killeen T
    63. Klipel J
    64. Laurance SG
    65. Laurance WF
    66. Fontes MAL
    67. Oviedo WL
    68. Magnusson WE
    69. Dos Santos RM
    70. Peña JLM
    71. de Abreu KMP
    72. Marimon B
    73. Junior BHM
    74. Melgaço K
    75. Melo Cruz OA
    76. Mendoza C
    77. Monteagudo-Mendoza A
    78. Morandi PS
    79. Gianasi FM
    80. Nascimento H
    81. Nascimento M
    82. Neill D
    83. Palacios W
    84. Camacho NCP
    85. Pardo G
    86. Pennington RT
    87. Peñuela-Mora MC
    88. Pitman NCA
    89. Poorter L
    90. Cruz AP
    91. Ramírez-Angulo H
    92. Reis SM
    93. Correa ZR
    94. Rodriguez CR
    95. Lleras AR
    96. Santos FAM
    97. Bergamin RS
    98. Schietti J
    99. Schwartz G
    100. Serrano J
    101. Silva-Sene AM
    102. Silveira M
    103. Stropp J
    104. Ter Steege H
    105. Terborgh J
    106. Tobler MW
    107. Gamarra LV
    108. van de Meer PJ
    109. van der Heijden G
    110. Vasquez R
    111. Vilanova E
    112. Vos VA
    113. Wolf A
    114. Woodall CW
    115. Wortel V
    116. Zwerts JA
    117. Pugh TAM
    118. Crowther TW
    The pace of life for forest trees.; Science (New York, N.Y.); Vol 386(6717), pp. 92-98. 2024 Oct 03.
    1. de Klerk HH
    2. Verweij LPE
    3. Doornberg JN
    4. Jaarsma RL
    5. Murase T
    6. Chen NC
    7. van den Bekerom MPJ
    8. Al K
    9. Ar B
    10. Ac W
    11. A VT
    12. Ac AP
    13. A T
    14. A B
    15. B M
    16. B T
    17. B J
    18. Cs M
    19. Cm L
    20. Cg L
    21. Cg T
    22. C R
    23. D R
    24. Ds R
    25. D E
    26. E AG
    27. E K
    28. Et E
    29. Gi B
    30. Jn L
    31. Ja W
    32. J P
    33. J A
    34. K S
    35. K S
    36. Al B
    37. Ms C
    38. M M
    39. Ml R
    40. Mj S
    41. N A
    42. N W
    43. Nwl S
    44. P A
    45. P M
    46. R B
    47. Rj T
    48. R VR
    49. R G
    50. S S
    51. Sd D
    52. S T
    53. T M
    54. Y C
    Factors associated with the choice of treatment for coronoid fractures.; The bone & joint journal; Vol 106-B(10), pp. 1150-1157. 2024 Oct 01.
    1. Cardoso A
    2. Quagliato LA
    3. Horato N
    4. Dutra PEP
    5. Nardi AE
    Linking head and heart health: the association between psychiatric outcomes for patients with major depressive disorder and myocardial ischemia - a systematic review.; Expert review of cardiovascular therapy. 2024 Oct 01.
    1. Mukherjee P
    2. Hou B
    3. Suri A
    4. Zhuang Y
    5. Parnell C
    6. Lee N
    7. Stroie O
    8. Jain R
    9. Wang KC
    10. Sharma K
    11. Summers RM
    Evaluation of GPT Large Language Model Performance on RSNA 2023 Case of the Day Questions.; Radiology; Vol 313(1), pp. e240609. 2024 Oct.

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  Looney Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642