URMC / Labs / Kottmann Lab / Publications Publications Lin XBai HBarravecchia MNorman RSchiralli Lester GMKottmann RMLeonard ARahman AYoung JLDean DA Occludin Is Essential to Maintain Normal Alveolar Barrier Integrity and Its Protective Role During ARDS Progression.; International journal of molecular sciences; Vol 25(21). 2024 Oct 29. Nagel DJRackow ARKu WYBell TJSime PJKottmann RM Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Inflammation and Fibrosis; Potential Implications for Idiopathic Pulmonary Fibrosis.; Cells; Vol 11(16). 2022 Aug 16. Bell TJNagel DJWoeller CFKottmann RM Ogerin mediated inhibition of TGF-β(1) induced myofibroblast differentiation is potentiated by acidic pH.; PloS one; Vol 17(7), pp. e0271608. 2022 Jul 28. Kalininskiy ARackow ARNagel DCroft DMcGrane-Minton HKottmann RM Association between weight loss and mortality in idiopathic pulmonary fibrosis.; Respiratory research; Vol 23(1), pp. 377. 2022 Jan 24. Rackow ARNagel DJZapas GClough RSSime PJKottmann RM The Novel Small Molecule BTB Inhibits Pro-Fibrotic Fibroblast Behavior though Inhibition of RhoA Activity.; International journal of molecular sciences; Vol 23(19). 2022 Jan 08. Rackow ARJudge JLWoller CFSime PJKottmann RM miR-338-3p Blocks TGFβ-Induced Myofibroblast Differentiation through the Induction of PTEN.; American journal of physiology. Lung cellular and molecular physiology. 2022 Jan 05. Croft DPBurton DSNagel DJBhattacharya SFalsey ARGeoras SNHopke PKJohnston CJKottmann RMLitonjua AAMariani TJRich DQThevenet-Morrison KThurston SWUtell MJMcCall MN The effect of air pollution on the transcriptomics of the immune response to respiratory infection.; Scientific reports; Vol 11(1). 2021 Sep 30. Rackow ARNagel DJMcCarthy CJudge JLacy SFreeberg MATThatcher THKottmann RMSime PJ The Self-fulfilling Prophecy of Pulmonary Fibrosis: A Selective Inspection of Pathologic Signaling Loops.; The European respiratory journal. 2020 Sep 17. Wu EKAmbrosini RDKottmann RMRitchlin CTSchwarz EMRahimi H Reinterpreting Evidence of Rheumatoid Arthritis-Associated Interstitial Lung Disease to Understand Etiology.; Current rheumatology reviews. 2019 Jan 15. Lachant DJCroft DPMcGrane Minton HHardy DJPrasad PKottmann RM The clinical impact of pneumocystis and viral PCR testing on bronchoalveolar lavage in immunosuppressed patients.; Respiratory medicine; Vol 145. 2018 Dec. Judge JLNagel DJOwens KMRackow APhipps RPSime PJKottmann RM Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol.; PloS one; Vol 13(5). 2018. Lachant DJCroft DPMcGrane Minton HPrasad PKottmann RM Nasopharyngeal viral PCR in immunosuppressed patients and its association with virus detection in bronchoalveolar lavage by PCR.; Respirology (Carlton, Vic.); Vol 22(6). 2017 Aug. Jackson TCZhang YVSime PJPhipps RPKottmann RM Development of an accurate and sensitive method for lactate analysis in exhaled breath condensate by LC MS/MS.; Journal of chromatography. B, Analytical technologies in the biomedical and life sciences; Vol 1061-1062. 2017 Jul 24. Judge JLLacy SHKu WYOwens KMHernady EThatcher THWilliams JPPhipps RPSime PJKottmann RM The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis.; Radiation research. 2017 May 02. Yee MDomm WGelein RBentley KLKottmann RMSime PJLawrence BPO'Reilly MA Alternative Progenitor Lineages Regenerate the Adult Lung Depleted of Alveolar Epithelial Type 2 Cells.; American journal of respiratory cell and molecular biology; Vol 56(4). 2017 Apr. Kottmann RMTrawick EJudge JLWahl LAEpa APOwens KMThatcher THPhipps RPSime PJ Pharmacologic inhibition of lactate production prevents myofibroblast differentiation.; American journal of physiology. Lung cellular and molecular physiology; Vol 309(11). 2015 Dec 1. Judge JLOwens KMPollock SJWoeller CFThatcher THWilliams JPPhipps RPSime PJKottmann RM Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase.; American journal of physiology. Lung cellular and molecular physiology; Vol 309(8). 2015 Oct 15. Croasdell AThatcher THKottmann RMColas RADalli JSerhan CNSime PJPhipps RP Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages.; American journal of physiology. Lung cellular and molecular physiology; Vol 309(8). 2015 Oct 15. Kottmann RMSharp JOwens KSalzman PXiao GQPhipps RPSime PJBrown EBPerry SW Second harmonic generation microscopy reveals altered collagen microstructure in usual interstitial pneumonia versus healthy lung.; Respiratory research; Vol 16(1). 2015 May 27. Jones KMRandtke EAHowison CMCárdenas-Rodríguez JSime PJKottmann MRPagel MD Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI.; Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging; Vol 17(2). 2015 Apr. Epa APThatcher THPollock SJWahl LALyda EKottmann RMPhipps RPSime PJ Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-β Induced Myofibroblast Differentiation via Prostaglandin E2.; PloS one; Vol 10(8). 2015. Olsen KCEpa APKulkarni AAKottmann RMMcCarthy CEJohnson GVThatcher THPhipps RPSime PJ Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules.; American journal of respiratory cell and molecular biology; Vol 50(4). 2014 Apr. Rosas IOKottmann RMKottman RMSime PJ New light is shed on the enigmatic origin of the lung myofibroblast.; American journal of respiratory and critical care medicine; Vol 188(7). 2013 Oct 1. Kulkarni AAThatcher THHsiao HMOlsen KCKottmann RMMorrissette JWright TWPhipps RPSime PJ The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis.; PloS one; Vol 8(5). 2013. Kottmann RMKulkarni AASmolnycki KALyda EDahanayake TSalibi RHonnons SJones CIsern NGHu JZNathan SDGrant GPhipps RPSime PJ Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β.; American journal of respiratory and critical care medicine; Vol 186(8). 2012 Oct 15. Davies ERHaitchi HMThatcher THSime PJKottmann RMGanesan APackham GO'Reilly KMDavies DE Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis.; American journal of respiratory cell and molecular biology; Vol 46(5). 2012 May. Olsen KCSapinoro REKottmann RMKulkarni AAIismaa SEJohnson GVThatcher THPhipps RPSime PJ Transglutaminase 2 and its role in pulmonary fibrosis.; American journal of respiratory and critical care medicine; Vol 184(6). 2011 Sep 15. Kottmann RMKelly JLyda EGurell MStalica JOrmsby WMoon KTrawick DSime PJ Bronchoscopy with bronchoalveolar lavage: determinants of yield and impact on management in immunosuppressed patients.; Thorax; Vol 66(9). 2011 Sep. Manganaris CWittlin SXu HGurell MSime PKottmann RM Metastatic papillary thyroid carcinoma and severe airflow obstruction.; Chest; Vol 138(3). 2010 Sep. Ferguson HEThatcher THOlsen KCGarcia-Bates TMBaglole CJKottmann RMStrong ERPhipps RPSime PJ Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism.; American journal of physiology. Lung cellular and molecular physiology; Vol 297(5). 2009 Nov. Kottmann RMHogan CMPhipps RPSime PJ Determinants of initiation and progression of idiopathic pulmonary fibrosis.; Respirology (Carlton, Vic.); Vol 14(7). 2009 Sep. Gurell MNKottmann RMXu HSime PJ Exogenous lipoid pneumonia: an unexpected complication of substance abuse.; Annals of internal medicine; Vol 149(5). 2008 Sep 2. Lakatos HFThatcher THKottmann RMGarcia TMPhipps RPSime PJ The Role of PPARs in Lung Fibrosis.; PPAR research; Vol 2007. 2007.