Recent Publications

2022

Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka S, Regan MS, Lin Y-F, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen Q-D, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman MA, Zacharias LG, Mathews TP, Losman JA, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdullah KG, Harris IS, Kaelin WG*, McBrayer SK*. De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma. Cancer Cell, Accepted in Principle.

Raymonda MH, Ciesla JH, Monaghan M, Leach J, Asantewaa G, Smorodintsev-Schiller LA, Lutz MM, Schafer XL, Takimoto T, Dewhurst S, Munger J**, Harris IS**. “Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro” Virology. 2022 Jan 1; 566: 60-68. https://doi.org/10.1016/j.virol.2021.11.008

2021

Asantewaa G, Harris IS. “Glutathione and its precursors in cancer” Curr Opin Biotechnol. 2021 Apr 2;68:292-299. https://doi.org/10.1016/j.copbio.2021.03.001.

Daniels VW, Zoeller JJ,van Gastel N, McQueeney KE, Parvin S, Potter DS, Fell GG, Ferreira VG, Yilma B, Gupta R, Spetz J, Bhola PD, Endress JE, Harris IS, Carrilho E, Sarosiek KA, Scadden DT, Brugge JS, Letai A. “ Metabolic perturbations sensitize triple-negative breast cancers to BH3 mimetics” Sci Signal. 2021 Jun 8;14(686):eabc7405. https://doi.org/10.1126/scisignal.abc7405. 

Zee BM, Poels KE, Yao C-H, Kawabata KC, Gongwei Wu G, Duy C, Jacobus WD, Senior E, Endress JE, Jambhekar A, Lovitch SB, Ma J, Dhall A, Harris IS, M. Blanco A, Sykes DB, Licht JD, Weinstock DM, Melnick A, Haigis MC, Michor F, Shi Y. “Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia” iScience. 2021 May 25;24(6):102651. https://doi.org/10.1016/j.isci.2021.102651.

Drijvers JM, Gillis JE, Muijlwijk T, Nguyen TH, Gaudiano EF, Harris IS, LaFleur MW, Ringel AE, Yao C-H, Kurmi K, Juneja VR, Trombley JD, Haigis MC and Arlene H. Sharpe AH “Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells” Cancer Immunol Res. 2021 Feb;9(2):184-199. https://doi.org/10.1158/2326-6066.CIR-20-0384.

Kang YP, Mockabee-Macias M, Jiang C, Harris IS, DeNicola GM. “Non-canonical glutamate-cysteine ligase activity protects against ferroptosis”. Cell Metab. 2021 Jan 5;33(1):174-189.e7. https://doi.org/10.1016/j.cmet.2020.12.007.

2020

Raymonda MH, Ciesla JH, Monaghan M, Leach J, Asantewaa G, Smorodintsev-Schiller LA, Lutz MM, Schafer XL, Takimoto T, Dewhurst S, Munger J**, Harris IS**. “Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro” bioRxiv. 2020. https://doi.org/10.1101/2020.11.25.398859. Preprint.

Kang YP, Mockabee-Macias M, Jiang C, Harris IS, DeNicola GM. “Non-canonical glutamate-cysteine ligase activity protects against ferroptosis”. bioRxiv. 2020. https://doi.org/10.1101/2020.05.29.123802. Preprint.

Takahashi N, Cho P, Selfors LM, Kuiken HJ, Kaul R, Fujiwara T, Harris IS, Zhang T, Gygi SP, Brugge JS. “3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis”. Mol Cell. 2020 Dec 3;80(5):828-844.e6. https://doi.org/10.1016/j.molcel.2020.10.010. Epub 2020 Oct 30.

Shu S, Wu H-J, Ge JY, Zeid R, Harris IS, Jovanovic B, Murphy K, Wang B, Qiu X., Endress JE, Reyes J, Lim K, Font-Tello A, Syamala S, Xiao T, Reddy Chilamakuri CS, Papachristou EK, D’Santos C, Anand J, Hinohara K, Li W, McDonald T, Luoma A, Modiste RJ, Nguyen Q-D, Michel B, Cejas P, Kadoch C, Jaffe JD, Wucherpfennig KW, Qi J, Liu XS, Long H, Brown M, Carroll JS, Brugge JS, Bradner J, Michor F, Polyak K. “Synthetic lethal and resistance interactions with BET bromodomain inhibitors in triple-negative breast cancer” Molecular Cell. 2020 May 7;S1097-2765(20)30269-0. https://doi.org/10.1016/j.molcel.2020.04.027

Harris IS**, DeNicola GM**. “The Complex Interplay between Antioxidants and ROS in Cancer” Trends in Cell Biology. April 2020; https://doi.org/10.1016/j.tcb.2020.03.002.

Kurniawan H, Franchina DG, Guerra L, Bonetti L, Soriano-Baguet L, Grusdat M, Schlicker L, Hunewald O, Dostert C, Merz MP, Binsfeld C, Duncan GS, Farinelle S, Nonnenmacher Y, Haight J, Das Gupta D, Ewen A, Taskesen R, Halder R, Chen Y, Jäger C, Ollert M, Wilmes P, Vasiliou V, Harris IS, Knobbe-Thomsen CB, Turner JD, Mak TW, Lohoff M, Meiser J, Hiller K, Brenner D. “Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function” Cell Metabolism. 2020 Mar 16. pii: S1550-4131(20)30119-4. https://doi.org/10.1016/j.cmet.2020.03.004

2019

Harris IS, Brugge JS. “United They Stand, Divided They Fall” Cell Metabolism. 2019 Oct 1; 30 (4): 624-625. https://doi.org/10.1016/j.cmet.2019.09.008

Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Harris IS, Endress JE, Kaelin WG. “HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species” Science Signaling. 2019 Oct 1; 601 (12). https://doi.org/10.1126/scisignal.aay0482

Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG, Brugge JS. “Deubiquitinases maintain protein homeostasis and survival of cancer cells upon glutathione depletion” Cell Metabolism. 2019 May 7; 29(5):1166-1181. https://doi.org/10.1016/j.cmet.2019.01.020

2018

Lee JJ, van de Ven RAH, Zaganjor E, Ng MR, Barakat A, Demmers JJPG, Finley LWS, Gonzalez Herrera KN, Hung YP, Harris IS, Jeong SM, Danuser G, McAllister SS, Marcia C. Haigis. “Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3” Proceedings of the National Academy of Sciences. 2018 July 3; 115 (27): 7057–7062. https://doi.org/10.1073/pnas.1800440115

Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS. “Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance” Cancer Cell. 2018 Jun 11; 33 (6): 985-1003. https://doi.org/10.1016/j.ccell.2018.05.001

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Dieter D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK-M, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D’Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin K-M, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine J-C, Martin SJ, Martinou J-C, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, HM Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon H-U, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G & Kroemer G. “Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018” Cell Death and Differentiation. 2018 Mar; 25 (3):486-541. https://doi.org/10.1038/s41418-017-0012-4

2017

Selfors LM, Stover DG, Harris IS, Brugge JS, Coloff JL. “Identification of cancer genes that are independent of dominant proliferation and lineage programs” Proceedings of the National Academy of Sciences. 2017 Dec 26; 114 (52): E11276-E11284. https://doi.org/10.1073/pnas.1714877115

Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D. “Glutathione primes T cell metabolism for inflammation” Immunity, 2017 April 18; 46 (4): 675-689. https://doi.org/10.1016/j.immuni.2017.03.019

2016

DeNicola GM**, Harris IS**. “Making sense of reAKTive oxygen species” Cell Death and Differentiation. 2016 Aug; 23(8): 1269-70. https://dx.doi.org/10.1038%2Fcdd.2016.57

Coloff JL, Murphy JP, Braun CR, Harris IS, Shelton LM, Kami K, Gygi SP, Selfors LM, Brugge JS. “Differential glutamate metabolism in proliferating and quiescent mammary epithelial cells” Cell Metabolism, 2016 May 19; 23 (5): 867-880. https://doi.org/10.1016/j.cmet.2016.03.016

2015

Harris IS**, Brugge JS**. “Cancer: The enemy of my enemy is my friend” Nature. 2015 Nov 12; 527 (7577): 170-1. https://doi.org/10.1038/nature15644

Itsumi M, Inoue S, Elia, AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio IIC, Afazal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW. “Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP+/NADPH ratio” Cell Death and Differentiation, 2015 November 1; 22 (11): 1837-1845. https://doi.org/10.1038/cdd.2015.38

Harris IS, Treloar AE, Sasaki M, Inoue S, Gorrini C, Lee KC, Yung KY, Knobbe-Thomsen CB, Brenner D, Cox MA, Elia A, Berger T, Cescon DW, Adeoye A, Brüstle A, Molyneux SD, Mason JM, Blaser H, Li WY, Wakeham A, Berman HK, Khokha R, Done S, Kavanagh TJ, Lam CW, Mak TW. “Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression” Cancer Cell. 2015 February 9; 27 (2): 211-222. https://doi.org/10.1016/j.ccell.2014.11.019

2014

Molyneux SD, Waterhouse PD, Shelton D, Shao YW, Watling CM, Tang QL, Harris IS, Dickson BC, Tharmapalan P, Sandve GK, Zhang X, Bailey SD, Berman H, Wunder JS, Iszvak Z, Lupien M, Mak TW, Khokha R. “Human somatic cell mutagenesis creates genetically tractable sarcomas” Nature Genetics. 2014 September; 46 (9): 964-972. https://doi.org/10.1038/ng.3065

Harris IS, Blaser H, Moreno J, Treloar AE, Gorrini C, Sasaki M, Mason JM, Knobbe CB, Rufini A, Hallé M, Elia AJ, Wakeham A, Tremblay ML, Melino G, Done S, Mak TW. “PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling” Oncogene. 2014 February 20; 33 (8): 1047-1054. https://doi.org/10.1038/onc.2013.24

Inoue S, Tomasini R, Rufini A, Elia AJ, Agostini M, Amelio I, Cescon D, Dinsdale D, Zhou L, Harris IS, Lac S, Silvester J, Li WY, Sasaki M, Haight J, Brüstle A, Wakeham A, Mckerlie C, Juriscova A, Melino G, Mak TW. “TAp73 is required for spermatogenesis and the maintenance of male fertility” Proceedings of the National Academy of Sciences. 2014 February 4: 111 (5): 1843-1848. https://doi.org/10.1073/pnas.1323416111

2013

Gorrini C*, Harris IS*, Mak TW. “Modulation of oxidative stress as an anticancer strategy” Nature Reviews Drug Discovery. 2013 December 1; 12 (12): 931-947. https://doi.org/10.1038/nrd4002

Gorrini C, Baniasadi PS, Harris IS, Silvester J, Inoue S, Snow B, Joshi PA, Wakeham A, Molyneux SD, Martin B, Bouwman P, Cescon DW, Elia AJ, Winterton-Perks Z, Cruickshank J, Brenner D, Tseng A, Musgrave M, Berman HK, Khokha R, Jonkers J, Mak TW, Gauthier ML. “BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival” Journal of Experimental Medicine. 2013 July 29; 210 (8): 1529-1544. https://doi.org/10.1084/jem.20121337

Föller M*, Harris IS*, Elia A, John R, Lang F, Kavanagh TJ, Mak TW. “Functional significance of glutamate-cysteine ligase modifier for erythrocyte survival in vitro and in vivo” Cell Death and Differentiation. 2013 June 21; 20: 1350-1358. https://doi.org/10.1038/cdd.2013.70

Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio IIC, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJZ, Melino G, Mak TW. “Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15” Genes and Development. 2013 May 15; 27 (10): 1101-1114. https://doi.org/10.1101/gad.214577.113

Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA, Harris IS, Shaabani N, Honke N, Kumar Maney S, Lang E, Pozdeev VI, Recher M, Odermatt B, Brenner D, Häussinger D, Ohashi PS, Hengartner H, Zinkernagel RM, Mak TW, Lang TW. “Reactive oxygen species delay control of lymphocytic choriomeningitis virus” Cell Death and Differentiation. 2013 January 18; 20: 649-658 https://doi.org/10.1038/cdd.2012.167

2012

Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio IIC, Cairns RA, McCracken S, Wakeham A, Haight J, You-Ten A, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW. “D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function” Genes and Development. 2012 September 15; 26 (18): 2038-2049. https://doi.org/10.1101/gad.198200.112

Rufini A, Niklison-Chirou MV, Inoue S, Tomasini R, Harris IS, Marino A., Federici M, Dinsdale D., Knight RA, Melino G, Mak TW. “TAp73 depletion accelerates aging through metabolic dysregulation” Genes and Development. 2012 September 15; 26 (18): 2009-2014. https://doi.org/10.1101/gad.197640.112

Sasaki, M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brüstle A, Harris IS, Holmes R, Wakeham A, Haight J, You-Ten A, Li WY, Schalm S, Su M, Virtanen C, Reifenberger G, Ohashi PS, Barber DL, Figueroa ME, Melnick A, Zúñiga-Pflücker JC, Mak TW. “IDH1 (R132H) mutation increases murine haematopoietic progenitors and alters epigenetics” Nature. 2012 July 4; 488 (7413): 656- 659. https://doi.org/10.1038/nature11323

Harris IS, McCracken S, Mak TW. “PKM2: A gatekeeper between growth and survival” Cell Research. 2011 December 20; 22: 447-449. https://doi.org/https://dx.doi.org/10.1038%2Fcr.2011.203 

2011

Karisch R, Fernandez M, Taylor P, Virtanen C, St-Germain JR, Jin LL, Harris IS, Mori J, Mak TW, Senis YA, Östman A, Moran MF, Neel BG. “Global proteomic assessment of the classical protein-tyrosine phosphatome and “Redoxome” Cell. 2011 September 2; 146 (5): 826-840. https://doi.org/10.1016/j.cell.2011.07.020

Cairns RA*, Harris IS*, Mak TW “Regulation of cancer cell metabolism” Nature Reviews Cancer. 2011 January 24; 11 (2): 85-95. https://doi.org/10.1038/nrc2981

Cairns RA*, Harris IS*, McCracken S, Mak TW. “Cancer cell metabolism” Cold Spring Harbor symposia on quantitative biology. 2011 January 1; 76: 299-311. https://doi.org/10.1101/sqb.2011.76.012856

2007

Bakker WJ, Harris IS, Mak TW. “FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2” Molecular Cell. 2007 December 28; 28 (6): 941-953. https://doi.org/10.1016/j.molcel.2007.10.035

*co-lead authors

**co-corresponding authors