study out today sheds new light on multiple sclerosis (MS), specifically damage in the brain caused by the disease
that may explain the slow and continuous cognitive decline that many patients experience. The findings, which
appear in the Journal of Neuroscience, show that the brain’s immune
system is responsible for disrupting communication between nerve cells, even in parts of the brain that are not normally
considered to be primary targets of the disease.
“This study identifies for the first time a new disease mechanism in MS which causes damage to neurons independent of
the loss of white matter and demyelination that is the hallmark of the disease,” said the lead author, neurologist
Matthew Bellizzi, M.D., Ph.D., with
the Center for Neural Development and Disease at the University of
Rochester Medical Center (URMC). “This damage represents another component of the disease and one that is not
prevented by the current immunosuppressive drugs employed to treat MS.”