URMC / Labs / Dunman Lab / Publications Publications Gondil VSButman HSYoung MWalsh DJNarkhede YZeiler MJCrow AHCarpenter MEMardikar AMelander RJWiest ODunman PMMelander C Development of phenyl-urea-based small molecules that target penicillin-binding protein 4.; Chemical biology & drug design; Vol 103(6), pp. e14569. 2024 Jun. Gowtham LWozniak RAFDunman PMSheba EGarg PJoseph J Efficacy of a Novel Antibiotic Drug Combination Toward Multidrug-Resistant Ocular Pathogens.; Cornea. 2024 Mar 26. Piraino LChen CYMereness JDunman PMOvitt CBenoit DDeLouise L Identifying novel radioprotective drugs via salivary gland tissue chip screening.; bioRxiv : the preprint server for biology. 2023 Jul 13. Young MChojnacki MBlanchard CCao XJohnson WLFlaherty DDunman PM Genetic Determinants of Acinetobacter baumannii Serum-Associated Adaptive Efflux-Mediated Antibiotic Resistance.; Antibiotics (Basel, Switzerland); Vol 12(7). 2023 Jul 11. King KABenton AHCaudill MTStoyanof STKang LMichalak PLahmers KKDunman PMDeHart TGAhmad SSJutras BLPoncin KDe Bolle XCaswell CC Post-transcriptional control of the essential enzyme MurF by a small regulatory RNA in Brucella abortus.; Molecular microbiology. 2023 Jan 11. Mei JAJohnson WKinn BLaskey ENolin LBhamare PStalker CDunman PMWozniak RAF Antimicrobial Activity of a Triple Antibiotic Combination Toward Ocular Pseudomonas aeruginosa Clinical Isolates.; Translational vision science & technology; Vol 11(5). 2022 May 02. Young MWalsh DJMasters EGondil VSLaskey EKlaczko MAwad HMcGrath JSchwarz EMMelander CDunman PM Identification of Staphylococcus aureus Penicillin Binding Protein 4 (PBP4) Inhibitors.; Antibiotics (Basel, Switzerland); Vol 11(10). 2022 Jan 04. Yang HKundra SChojnacki MLiu KFuse MAAbouelhassan YKallifidas DZhang PHuang GJin SDing YLuesch HRohde KHDunman PMLemos JAHuigens RW A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents.; Journal of medicinal chemistry. 2021 Apr 21. Suigo LChojnacki MZanotto CSebastián-Pérez VMorghen CGCasiraghi ADunman PMValoti EStraniero V Staphylococcus aureus RnpA Inhibitors: Computational-Guided Design, Synthesis and Initial Biological Evaluation.; Antibiotics (Basel, Switzerland); Vol 10(4). 2021 Apr 14. Chojnacki MCao XFlaherty DPDunman PM Optimization of 2-Acylaminocycloalkylthiophene Derivatives for Activity against Staphylococcus aureus RnpA.; Antibiotics (Basel, Switzerland); Vol 10(4). 2021 Mar 31. Chojnacki MDobrotka COsborn RJohnson WYoung MMeyer BLaskey EWozniak RAFDewhurst SDunman PM Evaluating the Antimicrobial Properties of Commercial Hand Sanitizers.; mSphere; Vol 6(2). 2021 Mar 03. Scherzi TD'Ambrosio EADaher SSGrimes CLDunman PMAndrade RB Staphylococcus aureus resistance to albocycline can be achieved by mutations that alter cellular NAD/PH pools.; Bioorganic & medicinal chemistry; Vol 32. 2021 Jan 07. Johnson WLSohn MBTaffner SChatterjee PDunman PMPecora NWozniak RAF Genomics of Staphylococcus aureus ocular isolates.; PloS one; Vol 16(5). 2021. Daher SSFranklin KPScherzi TDunman PMAndrade RB Synthesis and biological evaluation of semi-synthetic albocycline analogs.; Bioorganic & medicinal chemistry letters; Vol 30(21). 2020 Nov 01. Chojnacki MCao XYoung MFritz RNDunman PMFlaherty DP Optimization of 4-Substituted Benzenesulfonamide Scaffold To Reverse Acinetobacter baumannii Serum-Adaptive Efflux Associated Antibiotic Tolerance.; ChemMedChem; Vol 15(18). 2020 Sep 16. Morrison JMChojnacki MFadrowski JJBauza CDunman PMDudas RAGoldenberg NABerman DM Serum-Associated Antibiotic Tolerance in Pediatric Clinical Isolates of Pseudomonas aeruginosa.; Journal of the Pediatric Infectious Diseases Society. 2019 Dec 30. Chojnacki MPhilbrick AScherzi TPecora NDunman PMWozniak RAF A novel, broad-spectrum antimicrobial combination for the treatment of Pseudomonas aeruginosa corneal infections.; Antimicrobial agents and chemotherapy. 2019 Jul 22. Colquhoun JMHa LBeckley AMeyers BFlaherty DPDunman PM Identification of Small Molecule Inhibitors of Staphylococcus aureus RnpA.; Antibiotics (Basel, Switzerland); Vol 8(2). 2019 Apr 28. Trombetta RPNinomiya MJEl-Atawneh IMKnapp EKde Mesy Bentley KLDunman PMSchwarz EMKates SLAwad HA Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis.; Pharmaceutics; Vol 11(2). 2019 Feb 22. Shehatou CLogunov SLDunman PMHaidaris CGKlubben WS Characterizing the Antimicrobial Properties of 405 nm Light and the Corning® Light-Diffusing Fiber Delivery System.; Lasers in surgery and medicine; Vol 51(10). 2019 Jan. Chojnacki MPhilbrick AWucher BReed JNTomaras ADunman PMWozniak RAF Development of a broad-spectrum antimicrobial combination for the treatment of Staphylococcus aureus and Pseudomonas aeruginosa corneal infections.; Antimicrobial agents and chemotherapy. 2018 Nov 12. Trombetta RPDunman PMSchwarz EMKates SLAwad HA A High-Throughput Screening Approach To Repurpose FDA-Approved Drugs for Bactericidal Applications against Staphylococcus aureus Small-Colony Variants.; mSphere; Vol 3(5). 2018 Oct 31. Ha LColquhoun JNoinaj NDas CDunman PMFlaherty DP Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus.; Acta crystallographica. Section F, Structural biology communications; Vol 74(Pt 10). 2018 Oct 01. Liang HZhou GGe YD'Ambrosio EAEidem TMBlanchard CShehatou CChatare VKDunman PMValentine AMVoelz VAGrimes CLAndrade RB Elucidating the inhibition of peptidoglycan biosynthesis in Staphylococcus aureus by albocycline, a macrolactone isolated from Streptomyces maizeus.; Bioorganic & medicinal chemistry; Vol 26(12). 2018 Jul 23. Budnick JASheehan LMColquhoun JMDunman PMWalker GCRoop RMCaswell CC The endoribonuclease YbeY is linked to proper cellular morphology and virulence in Brucella abortus.; Journal of bacteriology. 2018 Apr 09. Lounsbury NEidem TColquhoun JMateo GAbou-Gharbia MDunman PMChilders WE Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin.; Bioorganic & medicinal chemistry letters; Vol 28(6). 2018 Apr 01. Schwan WRPolanowski RDunman PMMedina-Bielski SLane MRott MLipker LWescott AMonte ACook JMBaumann DDTiruveedhula VVNPBWitzigmann CMMikel CRahman MT Identification of Staphylococcus aureus Cellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray.; Antibiotics (Basel, Switzerland); Vol 6(3). 2017 Sep 11. Choby JEMike LAMashruwala AADutter BFDunman PMSulikowski GABoyd JMSkaar EP A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus.; Cell chemical biology; Vol 23(11). 2016 Nov 17. Blanchard CBrooks LEbsworth-Mojica KDidione LWucher BDewhurst SKrysan DDunman PMWozniak RA Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment.; mSphere; Vol 1(5). 2016 Sep. Blanchard CBrooks LBeckley AColquhoun JDewhurst SDunman PM Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments.; Antimicrobial agents and chemotherapy; Vol 60(2). 2016 Feb. Wilde ADSnyder DJPutnam NEValentino MDHammer NDLonergan ZRHinger SAAysanoa EEBlanchard CDunman PMWasserman GAChen JShopsin BGilmore MSSkaar EPCassat JE Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection.; PLoS pathogens; Vol 11(12). 2015 Dec. Sheehan LMBudnick JABlanchard CDunman PMCaswell CC A LysR-family transcriptional regulator required for virulence in Brucella abortus is highly conserved among the α-proteobacteria.; Molecular microbiology; Vol 98(2). 2015 Oct. Tomaras APDunman PM In the midst of the antimicrobial discovery conundrum: an overview.; Current opinion in microbiology; Vol 27. 2015 Oct. Dunman PMTomaras AP Translational deficiencies in antibacterial discovery and new screening paradigms.; Current opinion in microbiology; Vol 27. 2015 Oct. Dunman PMTomaras AP Editorial overview: Antimicrobials.; Current opinion in microbiology; Vol 27. 2015 Oct. Eidem TMLounsbury NEmery JFBulger JSmith AAbou-Gharbia MChilders WDunman PM Small-molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing.; Antimicrobial agents and chemotherapy; Vol 59(4). 2015 Apr. Mootz JMBenson MAHeim CECrosby HAKavanaugh JSDunman PMKielian TTorres VJHorswill AR Rot is a key regulator of Staphylococcus aureus biofilm formation.; Molecular microbiology; Vol 96(2). 2015 Apr. Forbes LEbsworth-Mojica KDiDone LLi SGFreundlich JSConnell NDunman PMKrysan DJ A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis.; PloS one; Vol 10(6). 2015. Colquhoun JMWozniak RADunman PM Clinically Relevant Growth Conditions Alter Acinetobacter baumannii Antibiotic Susceptibility and Promote Identification of Novel Antibacterial Agents.; PloS one; Vol 10(11). 2015. Blanchard CBarnett PPerlmutter JDunman PM Identification of Acinetobacter baumannii serum-associated antibiotic efflux pump inhibitors.; Antimicrobial agents and chemotherapy; Vol 58(11). 2014 Nov. Perlmutter JIForbes LTKrysan DJEbsworth-Mojica KColquhoun JMWang JLDunman PMFlaherty DP Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.; Journal of medicinal chemistry; Vol 57(20). 2014 Oct 23. Olson METodd DASchaeffer CRPaharik AEVan Dyke MJBüttner HDunman PMRohde HCech NBFey PDHorswill AR Staphylococcus epidermidis agr quorum-sensing system: signal identification, cross talk, and importance in colonization.; Journal of bacteriology; Vol 196(19). 2014 Oct. Lindgren JKThomas VCOlson MEChaudhari SSNuxoll ASSchaeffer CRLindgren KEJones JZimmerman MCDunman PMBayles KWFey PD Arginine deiminase in Staphylococcus epidermidis functions to augment biofilm maturation through pH homeostasis.; Journal of bacteriology; Vol 196(12). 2014 Jun. Eidem TMCoughlan ATowler MRDunman PMWren AW Drug-eluting cements for hard tissue repair: a comparative study using vancomycin and RNPA1000 to inhibit growth of Staphylococcus aureus.; Journal of biomaterials applications; Vol 28(8). 2014 Apr. Jacobs ACBlanchard CECatherman SCDunman PMMurata Y An ribonuclease T2 family protein modulates Acinetobacter baumannii abiotic surface colonization.; PloS one; Vol 9(1). 2014. Hanses FRoux CDunman PMSalzberger BLee JC Staphylococcus aureus gene expression in a rat model of infective endocarditis.; Genome medicine; Vol 6(10). 2014. Scherr TDRoux CMHanke MLAngle ADunman PMKielian T Global transcriptome analysis of Staphylococcus aureus biofilms in response to innate immune cells.; Infection and immunity; Vol 81(12). 2013 Dec. Easterhoff DOntiveros FBrooks LRKim YRoss BSilva JNOlsen JSFeng CHardy DJDunman PMDewhurst S Semen-derived enhancer of viral infection (SEVI) binds bacteria, enhances bacterial phagocytosis by macrophages, and can protect against vaginal infection by a sexually transmitted bacterial pathogen.; Antimicrobial agents and chemotherapy; Vol 57(6). 2013 Jun. Caswell CCElhassanny AEPlanchin EERoux CMWeeks-Gorospe JNFicht TADunman PMRoop RM Diverse genetic regulon of the virulence-associated transcriptional regulator MucR in Brucella abortus 2308.; Infection and immunity; Vol 81(4). 2013 Apr. Hood MIBecker KWRoux CMDunman PMSkaar EP genetic determinants of intrinsic colistin tolerance in Acinetobacter baumannii.; Infection and immunity; Vol 81(2). 2013 Feb.