Recent Publications

• 1. Du T
  2. Raghunandan A
  3. Mestre H
  4. Plá V
  5. Liu G
  6. Ladrón-de-Guevara A
  7. Newbold E
  8. Tobin P
  9. Gahn-Martinez D
  10. Pattanayak S
  11. Huang Q
  12. Peng W
  13. Nedergaard M
  14. Kelley DH
  Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage.; Nature aging. 2024 Aug 15.
• 1. Raicevic N
  2. Forer JM
  3. Ladrón-de-Guevara A
  4. Du T
  5. Nedergaard M
  6. Kelley DH
  7. Boster K
  Sizes and shapes of perivascular spaces surrounding murine pial arteries.; Fluids and barriers of the CNS; Vol 20(1), pp. 56. 2023 Jul 17.
• 1. Boster KAS
  2. Cai S
  3. Ladrón-de-Guevara A
  4. Sun J
  5. Zheng X
  6. Du T
  7. Thomas JH
  8. Nedergaard M
  9. Karniadakis GE
  10. Kelley DH
  Artificial intelligence velocimetry reveals in vivo flow rates, pressure gradients, and shear stresses in murine perivascular flows.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(14), pp. e2217744120. 2023 Mar 29.
• 1. Gomolka RS
  2. Hablitz LM
  3. Mestre H
  4. Giannetto M
  5. Du T
  6. Hauglund NL
  7. Xie L
  8. Peng W
  9. Martinez PM
  10. Nedergaard M
  11. Mori Y
  Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation.; eLife; Vol 12. 2023 Feb 09.
• 1. Wang X
  2. Delle C
  3. Peng W
  4. Plá V
  5. Giannetto M
  6. Kusk P
  7. Sigurdsson B
  8. Sakurai S
  9. Sweeney A
  10. Sun Q
  11. Du T
  12. Libby RT
  13. Nedergaard M
  Age- and glaucoma-induced changes to the ocular glymphatic system.; Neurobiology of disease. 2023 Jan 11.
• 1. Liu G
  2. Ladrón-de-Guevara A
  3. Izhiman Y
  4. Nedergaard M
  5. Du T
  Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies.; Fluids and barriers of the CNS; Vol 19(1), pp. 101. 2022 Jan 15.
• 1. Du T
  2. Mestre H
  3. Kress BT
  4. Liu G
  5. Sweeney AM
  6. Samson AJ
  7. Rasmussen MK
  8. Mortensen KN
  9. Bork PAR
  10. Peng W
  11. Olveda GE
  12. Bashford L
  13. Toro ER
  14. Tithof J
  15. Kelley DH
  16. Thomas JH
  17. Hjorth PG
  18. Martens EA
  19. Mehta RI
  20. Hirase H
  21. Mori Y
  22. Nedergaard M
  Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema.; Brain : a journal of neurology. 2021 Sep 28.
• 1. Raghunandan A
  2. Ladron-de-Guevara A
  3. Tithof J
  4. Mestre H
  5. Du T
  6. Nedergaard M
  7. Thomas JH
  8. Kelley DH
  Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection.; eLife; Vol 10. 2021 Mar 09.
• 1. Liu G
  2. Mestre H
  3. Sweeney AM
  4. Sun Q
  5. Weikop P
  6. Du T
  7. Nedergaard M
  Direct Measurement of Cerebrospinal Fluid Production in Mice.; Cell reports; Vol 33(12). 2020 Dec 22.
• 1. Min Rivas F
  2. Liu J
  3. Martell BC
  4. Du T
  5. Mestre H
  6. Nedergaard M
  7. Tithof J
  8. Thomas JH
  9. Kelley DH
  Surface periarterial spaces of the mouse brain are open, not porous.; Journal of the Royal Society, Interface; Vol 17(172). 2020 Nov.
• 1. Mestre H
  2. Du T
  3. Sweeney AM
  4. Liu G
  5. Samson AJ
  6. Peng W
  7. Mortensen KN
  8. Stæger FF
  9. Bork PAR
  10. Bashford L
  11. Toro ER
  12. Tithof J
  13. Kelley DH
  14. Thomas JH
  15. Hjorth PG
  16. Martens EA
  17. Mehta RI
  18. Solis O
  19. Blinder P
  20. Kleinfeld D
  21. Hirase H
  22. Mori Y
  23. Nedergaard M
  Cerebrospinal fluid influx drives acute ischemic tissue swelling.; Science (New York, N.Y.). 2020 Jan 30.
• 1. Sweeney AM
  2. Plá V
  3. Du T
  4. Liu G
  5. Sun Q
  6. Peng S
  7. Plog BA
  8. Kress BT
  9. Wang X
  10. Mestre H
  11. Nedergaard M
  In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy.; Journal of visualized experiments : JoVE. 2019 Jul 29.
• 1. Lilius TO
  2. Blomqvist K
  3. Hauglund NL
  4. Liu G
  5. Stæger FF
  6. Bærentzen S
  7. Du T
  8. Ahlström F
  9. Backman JT
  10. Kalso EA
  11. Rauhala PV
  12. Nedergaard M
  Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs.; Journal of controlled release : official journal of the Controlled Release Society; Vol 304. 2019 Jun 28.
• 1. Mestre H
  2. Hablitz LM
  3. Xavier AL
  4. Feng W
  5. Zou W
  6. Pu T
  7. Monai H
  8. Murlidharan G
  9. Castellanos Rivera RM
  10. Simon MJ
  11. Pike MM
  12. Plá V
  13. Du T
  14. Kress BT
  15. Wang X
  16. Plog BA
  17. Thrane AS
  18. Lundgaard I
  19. Abe Y
  20. Yasui M
  21. Thomas JH
  22. Xiao M
  23. Hirase H
  24. Asokan A
  25. Iliff JJ
  26. Nedergaard M
  Aquaporin-4-dependent glymphatic solute transport in the rodent brain.; eLife; Vol 7. 2018 Dec 18.
• 1. Mestre H
  2. Tithof J
  3. Du T
  4. Song W
  5. Peng W
  6. Sweeney AM
  7. Olveda G
  8. Thomas JH
  9. Nedergaard M
  10. Kelley DH
  Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.; Nature communications; Vol 9(1). 2018 Nov 19.
• 1. Plog BA
  2. Mestre H
  3. Olveda GE
  4. Sweeney AM
  5. Kenney HM
  6. Cove A
  7. Dholakia KY
  8. Tithof J
  9. Nevins TD
  10. Lundgaard I
  11. Du T
  12. Kelley DH
  13. Nedergaard M
  Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.; JCI insight; Vol 3(20). 2018 Oct 18.
• 1. Du T
  2. Rong Y
  3. Feng R
  4. Verkhratsky A
  5. Peng L
  Chronic Treatment with Anti-bipolar Drugs Down-Regulates Gene Expression of TRPC1 in Neurones.; Frontiers in cellular neuroscience; Vol 10. 2016.
• 1. Zhou J
  2. Du T
  3. Li B
  4. Rong Y
  5. Verkhratsky A
  6. Peng L
  Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion.; ASN neuro; Vol 7(5). 2015 Sep.
• 1. Wang F
  2. Du T
  3. Liang C
  4. Verkhratsky A
  5. Peng L
  Ammonium increases Ca(2+) signalling and upregulates expression of Cav1.2 gene in astrocytes in primary cultures and in the in vivo brain.; Acta physiologica (Oxford, England); Vol 214(2). 2015 Jun.
• 1. Hertz L
  2. Xu J
  3. Song D
  4. Du T
  5. Li B
  6. Yan E
  7. Peng L
  Astrocytic glycogenolysis: mechanisms and functions.; Metabolic brain disease; Vol 30(1). 2015 Feb.
• 1. Chen Y
  2. Du T
  3. Peng L
  4. Gibbs ME
  5. Hertz L
  Sequential Astrocytic 5-HT2B Receptor Stimulation, [Ca(2+)]i Regulation, Glycogenolysis, Glutamate Synthesis, and K(+) Homeostasis are Similar but Not Identical in Learning and Mood Regulation.; Frontiers in integrative neuroscience; Vol 9. 2015.
• 1. Liang C
  2. Du T
  3. Zhou J
  4. Verkhratsky A
  5. Peng L
  Ammonium increases Ca(2+) signalling and up-regulates expression of TRPC1 gene in astrocytes in primary cultures and in the in vivo brain.; Neurochemical research; Vol 39(11). 2014 Nov.
• 1. Hertz L
  2. Xu J
  3. Chen Y
  4. Gibbs ME
  5. Du T
  6. Hertz L
  7. Xu J
  8. Chen Y
  9. Gibbs ME
  10. Du T
  Antagonists of the Vasopressin V1 Receptor and of the β(1)-Adrenoceptor Inhibit Cytotoxic Brain Edema in Stroke by Effects on Astrocytes - but the Mechanisms Differ.; Current neuropharmacology; Vol 12(4). 2014 Jul.
• 1. Song D
  2. Du T
  Ammonium activates ouabain-activated signalling pathway in astrocytes: therapeutic potential of ouabain antagonist.; Current neuropharmacology; Vol 12(4). 2014 Jul.
• 1. Du T
  2. Liang C
  3. Li B
  4. Hertz L
  5. Peng L
  Chronic fluoxetine administration increases expression of the L-channel gene Cav1.2 in astrocytes from the brain of treated mice and in culture and augments K(+)-induced increase in [Ca(2+)]i.; Cell calcium; Vol 55(3). 2014 Mar.
• 1. Song D
  2. Xu J
  3. Du T
  4. Yan E
  5. Hertz L
  6. Walz W
  7. Peng L
  Inhibition of brain swelling after ischemia-reperfusion by β-adrenergic antagonists: correlation with increased K+ and decreased Ca2+ concentrations in extracellular fluid.; BioMed research international; Vol 2014. 2014.
• 1. Hertz L
  2. Song D
  3. Li B
  4. Du T
  5. Xu J
  6. Gu L
  7. Chen Y
  8. Peng L
  Signal Transduction in Astrocytes during Chronic or Acute Treatment with Drugs (SSRIs, Antibipolar Drugs, GABA-ergic Drugs, and Benzodiazepines) Ameliorating Mood Disorders.; Journal of signal transduction; Vol 2014. 2014.
• 1. Hertz L
  2. Song D
  3. Xu J
  4. Du T
  5. Gu L
  6. Peng L
  When can AQP4 assist transporter-mediated K⁺ uptake?; The Journal of general physiology; Vol 142(1). 2013 Jul.
• 1. Hertz L
  2. Xu J
  3. Song D
  4. Du T
  5. Yan E
  6. Peng L
  Brain glycogenolysis, adrenoceptors, pyruvate carboxylase, Na(+),K(+)-ATPase and Marie E. Gibbs' pioneering learning studies.; Frontiers in integrative neuroscience; Vol 7. 2013.
• 1. Desjardins P
  2. Du T
  3. Jiang W
  4. Peng L
  5. Butterworth RF
  Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined.; Neurochemistry international; Vol 60(7). 2012 Jun.
• 1. Peng L
  2. Li B
  3. Du T
  4. Wang F
  5. Hertz L
  Does conventional anti-bipolar and antidepressant drug therapy reduce NMDA-mediated neuronal excitation by downregulating astrocytic GluK2 function?; Pharmacology, biochemistry, and behavior; Vol 100(4). 2012 Feb.
• 1. Cai L
  2. Du T
  3. Song D
  4. Li B
  5. Hertz L
  6. Peng L
  Astrocyte ERK phosphorylation precedes K(+)-induced swelling but follows hypotonicity-induced swelling.; Neuropathology : official journal of the Japanese Society of Neuropathology; Vol 31(3). 2011 Jun.
• 1. Peng L
  2. Li B
  3. Du T
  4. Kong EK
  5. Hu X
  6. Zhang S
  7. Shan X
  8. Zhang M
  Astrocytic transactivation by alpha2A-adrenergic and 5-HT2B serotonergic signaling.; Neurochemistry international; Vol 57(4). 2010 Nov.
• 1. Du T
  2. Li B
  3. Li H
  4. Li M
  5. Hertz L
  6. Peng L
  Signaling pathways of isoproterenol-induced ERK1/2 phosphorylation in primary cultures of astrocytes are concentration-dependent.; Journal of neurochemistry; Vol 115(4). 2010 Nov.
• 1. Du T
  2. Li B
  3. Liu S
  4. Zang P
  5. Prevot V
  6. Hertz L
  7. Peng L
  ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors.; Neurochemistry international; Vol 55(7). 2009 Dec.
• 1. Song D
  2. Du T
  3. Li B
  4. Cai L
  5. Gu L
  6. Li H
  7. Chen Y
  8. Hertz L
  9. Peng L
  Astrocytic alkalinization by therapeutically relevant lithium concentrations: implications for myo-inositol depletion.; Psychopharmacology; Vol 200(2). 2008 Oct.
• 1. Du T
  2. Song D
  3. Li H
  4. Li B
  5. Cai L
  6. Hertz L
  7. Peng L
  Stimulation by vasopressin of ERK phosphorylation and vector-driven water flux in astrocytes is transactivation-dependent.; European journal of pharmacology; Vol 587(1-3). 2008 Jun 10.
• 1. Li B
  2. Du T
  3. Li H
  4. Gu L
  5. Zhang H
  6. Huang J
  7. Hertz L
  8. Peng L
  Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons.; British journal of pharmacology; Vol 154(1). 2008 May.