URMC / Labs / Dewhurst Lab / Publications Publications Rahman SMBuchholz DWImbiakha BJager MCLeach JOsborn RMBirmingham AODewhurst SAguilar HCLuebke AE Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2-infected older mice with neurological signs.; Journal of virology. 2024 May 30. Zand MSSpallina SRoss AZandi KPawlowski ASeplaki CLHerington JCorbett AMKaukeinen KHolden-Wiltse JFreedman EGAlcantara LLi DCameron ABeaumont NDozier ADewhurst SFoxe JJ Ventilation during COVID-19 in a school for students with intellectual and developmental disabilities (IDD).; PloS one; Vol 19(4), pp. e0291840. 2024 Apr 03. Imbiakha BSahler JMBuchholz DWEzzatpour SJager MChoi AMonreal IAByun HAdeleke RALeach JWhittaker GDewhurst SRudd BDAguilar HCAugust A Adaptive immune cells are necessary for SARS-CoV-2-induced pathology.; Science advances; Vol 10(1), pp. eadg5461. 2024 Jan 03. Zand MSSpallina SRoss AZandi KPawlowski ASeplaki CLHerington JCorbett AMKaukeinen KHolden-Wiltse JFreedman EGAlcantara LLi DCameron ABeaumont NDozier ADewhurst SFoxe JJ Ventilation during COVID-19 in a school for students with intellectual and developmental disabilities (IDD).; medRxiv : the preprint server for health sciences. 2023 Sep 10. Schuster JEErickson TRGoldman JLBenjamin DKBrookhart MADewhurst SFist AFoxe JGodambe MGwynn LKiene SMKeener Mast DMcDaniels-Davidson CNewland JGOren ESelvarangan RShinde NWalsh TWatterson TZand MZimmerman KOKalu IC Utilization and Impact of Symptomatic and Exposure SARS-CoV-2 Testing in K-12 Schools.; Pediatrics; Vol 152(Suppl 1). 2023 Jul 01. Goldman JLKalu ICSchuster JEErickson TMast DKZimmerman KBenjamin DKKalb LGGurnett CNewland JGSherby MGodambe MShinde NWatterson TWalsh TFoxe JZand MDewhurst SColler RDeMuri GPArchuleta SKo LKInkelas MManuel VLee ROh HMurugan VKramer JOkihiro MGwynn LPulgaron EMcCulloh RBroadhurst JMcDaniels-Davidson CKiene SOren EWu YWetter DWStump TBrookhart MAFist AHaroz E Building School-Academic Partnerships to Implement COVID-19 Testing in Underserved Populations.; Pediatrics; Vol 152(Suppl 1). 2023 Jul 01. Zhou TGilliam NJLi SSpandau SOsborn RMConnor SAnderson CSMariani TJThakar JDewhurst SMathews DHHuang LSun Y Generation and Functional Analysis of Defective Viral Genomes during SARS-CoV-2 Infection.; mBio. 2023 Apr 19. Osborn RMLeach JZanche MAshton JMChu CThakar JDewhurst SRosenberger SPavelka MPryhuber GSMariani TJAnderson CS Preparation of noninfectious scRNAseq samples from SARS-CoV-2-infected epithelial cells.; PloS one; Vol 18(2), pp. e0281898. 2023 Feb 24. Molina Vargas AMSinha SOsborn RArantes PRPatel ADewhurst SHardy DJCameron APalermo GO'Connell MR New design strategies for ultra-specific CRISPR-Cas13a-based RNA detection with single-nucleotide mismatch sensitivity.; Nucleic acids research. 2023 Jan 30. Zhou TGilliam NJLi SSpaudau SOsborn RMAnderson CSMariani TJThakar JDewhurst SMathews DHHuang LSun Y Generation and functional analysis of defective viral genomes during SARS-CoV-2 infection.; bioRxiv : the preprint server for biology. 2022 Sep 23. Nogales ASteel JLiu WCLowen ACRodriguez LChiem KCox AGarcía-Sastre AAlbrecht RADewhurst SMartínez-Sobrido L Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus Vaccine.; Microbiology spectrum. 2022 May 18. Raymonda MHCiesla JHMonaghan MLeach JAsantewaa GSmorodintsev-Schiller LALutz MMSchafer XLTakimoto TDewhurst SMunger JHarris IS Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro.; Virology; Vol 566. 2021 Nov 27. Sherby MRKalb LGColler RJDeMuri GPButteris SFoxe JJZand MSFreedman EGDewhurst SNewland JGGurnett CA Supporting COVID-19 School Safety for Children With Disabilities and Medical Complexity.; Pediatrics. 2021 Nov 04. Chojnacki MDobrotka COsborn RJohnson WYoung MMeyer BLaskey EWozniak RAFDewhurst SDunman PM Evaluating the Antimicrobial Properties of Commercial Hand Sanitizers.; mSphere; Vol 6(2). 2021 Mar 03. Cox ASchmierer JD'Angelo JSmith ALevenson DTreanor JKim BDewhurst S A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.; Viruses; Vol 12(11). 2020 Oct 31. Simpson SRSingh MVDewhurst SSchifitto GMaggirwar SB Platelets function as an acute viral reservoir during HIV-1 infection by harboring virus and T-cell complex formation.; Blood advances; Vol 4(18). 2020 Sep 22. Piekna-Przybylska DBambara RAMaggirwar SBDewhurst S G-quadruplex ligands targeting telomeres do not inhibit HIV promoter activity and cooperate with latency reversing agents in killing latently infected cells.; Cell cycle (Georgetown, Tex.). 2020 Aug 17. Ma QSchifitto GVenuto COcque ADewhurst SMorse GDAalinkeel RSchwartz SAMahajan SD Effect of Dolutegravir and Sertraline on the Blood Brain Barrier (BBB).; Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology; Vol 15(1). 2020 Mar. Smith ARodriguez LGhouayel MENogales AChamberlain JMSortino KReilly EFeng CTopham DJMartínez-Sobrido LDewhurst S A live-attenuated influenza vaccine (LAIV) elicits enhanced heterologous protection when the internal genes of the vaccine are matched to the challenge virus.; Journal of virology. 2019 Nov 20. Rodriguez LBlanco-Lobo PReilly ECMaehigashi TNogales ASmith ATopham DJDewhurst SKim BMartínez-Sobrido L Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines.; Viruses; Vol 11(10). 2019 Oct 10. Chamberlain JMSortino KSethna PBae ALanier RBambara RADewhurst S Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus.; Antimicrobial agents and chemotherapy; Vol 63(1). 2019 Jan. Mathew EZhu HConnelly SMSullivan MABrewer MGPiepenbrink MSKobie JJDewhurst SDumont ME Display of the HIV envelope protein at the yeast cell surface for immunogen development.; PloS one; Vol 13(10). 2018. Sheik DADewhurst SYang J Natural Seminal Amyloids as Targets for Development of Synthetic Inhibitors of HIV Transmission.; Accounts of chemical research; Vol 50(9). 2017 Sep 19. Hilimire TAChamberlain JMAnokhina VBennett RPSwart OMyers JRAshton JMStewart RAFeatherston ALGates KHelms EDSmith HCDewhurst SMiller BL HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells.; ACS chemical biology. 2017 May 05. Sheik DAChamberlain JMBrooks LClark MKim YHLeriche GKubiak CPDewhurst SYang J Hydrophobic Nanoparticles Reduce the β-Sheet Content of SEVI Amyloid Fibrils and Inhibit SEVI-Enhanced HIV Infectivity.; Langmuir : the ACS journal of surfaces and colloids; Vol 33(10). 2017 Mar 14. Brewer MGDiPiazza AAcklin JFeng CSant AJDewhurst S Nanoparticles decorated with viral antigens are more immunogenic at low surface density.; Vaccine; Vol 35(5). 2017 Feb 01. Buckley GSmith SDeCaro JBarnett SDewhurst S Building community for deaf scientists.; Science (New York, N.Y.); Vol 355(6322). 2017 Jan 20. Mattiacio JLBrewer MDewhurst S Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform.; Methods in molecular biology (Clifton, N.J.); Vol 1581. 2017. Blanchard CBrooks LEbsworth-Mojica KDidione LWucher BDewhurst SKrysan DDunman PMWozniak RA Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment.; mSphere; Vol 1(5). 2016 Sep. Blanchard CBrooks LBeckley AColquhoun JDewhurst SDunman PM Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments.; Antimicrobial agents and chemotherapy; Vol 60(2). 2016 Feb. Nishimura CPolesskaya ODewhurst SSilva JN Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation.; Journal of visualized experiments : JoVE. 2016. Puccini JMMarker DFFitzgerald TBarbieri JKim CSMiller-Rhodes PLu SMDewhurst SGelbard HA Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(13). 2015 Apr 1. Cox ABaker SFNogales AMartínez-Sobrido LDewhurst S Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine.; Journal of virology; Vol 89(6). 2015 Mar. Sheik DABrooks LFrantzen KDewhurst SYang J Inhibition of the enhancement of infection of human immunodeficiency virus by semen-derived enhancer of virus infection using amyloid-targeting polymeric nanoparticles.; ACS nano; Vol 9(2). 2015 Feb 24. Cox ADewhurst S A Single Mutation at PB1 Residue 319 Dramatically Increases the Safety of PR8 Live Attenuated Influenza Vaccine in a Murine Model without Compromising Vaccine Efficacy.; Journal of virology; Vol 90(5). 2015. Ying BTollefson AESpencer JFBalakrishnan LDewhurst SCapella CBuller RMToth KWold WS Ganciclovir inhibits human adenovirus replication and pathogenicity in permissive immunosuppressed Syrian hamsters.; Antimicrobial agents and chemotherapy; Vol 58(12). 2014 Dec. Silva JNPolesskaya OWei HSRasheed IYChamberlain JMNishimura CFeng CDewhurst S Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity.; Microcirculation (New York, N.Y. : 1994); Vol 21(7). 2014 Oct. Nogales ABaker SFOrtiz-Riaño EDewhurst STopham DJMartínez-Sobrido L Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development.; Journal of virology; Vol 88(18). 2014 Sep. Polesskaya OWong CLebron LChamberlain JMGelbard HAGoodfellow VKim MDaiss JLDewhurst S MLK3 regulates fMLP-stimulated neutrophil motility.; Molecular immunology; Vol 58(2). 2014 Apr. Domm WBrewer MBaker SFFeng CMartínez-Sobrido LTreanor JDewhurst S Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies.; Journal of virological methods; Vol 197. 2014 Mar. Lewis CADewhurst SMcMahon JMBunce CAKeefer MCAlio AP Theoretical model of critical issues in informed consent in HIV vaccine trials.; AIDS care; Vol 26(11). 2014. Rhoo KHGranger MSur JFeng CGelbard HADewhurst SPolesskaya O Pharmacologic Inhibition of MLK3 Kinase Activity Blocks the In Vitro Migratory Capacity of Breast Cancer Cells but Has No Effect on Breast Cancer Brain Metastasis in a Mouse Xenograft Model.; PloS one; Vol 9(9). 2014. Easterhoff DDiMaio JTLiyanage WLo CWBae WDoran TMSmrcka ANilsson BLDewhurst S Fluorescence detection of cationic amyloid fibrils in human semen.; Bioorganic & medicinal chemistry letters; Vol 23(18). 2013 Sep 15. Lu NSilva JGu YGerber SWu HGelbard HDewhurst SMiao H Directional Histogram Ratio at Random Probes: A Local Thresholding Criterion for Capillary Images.; Pattern recognition; Vol 46(7). 2013 Jul 01. Marker DFTremblay MÈPuccini JMBarbieri JGantz Marker MALoweth CJMuly ECLu SMGoodfellow VSDewhurst SGelbard HA The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 33(24). 2013 Jun 12. Ma QGelbard HAMaggirwar SBDewhurst SGendelman HEPeterson DRDiFrancesco RHochreiter JSMorse GDSchifitto G Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients.; Journal of neurovirology; Vol 19(3). 2013 Jun. Arany SBenoit DSDewhurst SOvitt CE Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 21(6). 2013 Jun. Easterhoff DOntiveros FBrooks LRKim YRoss BSilva JNOlsen JSFeng CHardy DJDunman PMDewhurst S Semen-derived enhancer of viral infection (SEVI) binds bacteria, enhances bacterial phagocytosis by macrophages, and can protect against vaginal infection by a sexually transmitted bacterial pathogen.; Antimicrobial agents and chemotherapy; Vol 57(6). 2013 Jun. Sullivan MABrooks LRWeidenborner PDomm WMattiacio JXu QTiberio MWentworth TKobie JBryk PZheng BMurphy MSanz IDewhurst S Anti-idiotypic monobodies derived from a fibronectin scaffold.; Biochemistry; Vol 52(10). 2013 Mar 12. Alcéna DCKobie JJKaminski DARosenberg AFMattiacio JLBrewer MDewhurst SDykes CJin XKeefer MCSanz I 9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profiles.; PloS one; Vol 8(12). 2013.