Publications

• 1. Bell RD
  2. Winkler EA
  3. Singh I
  4. Sagare AP
  5. Deane R
  6. Wu Z
  7. Holtzman DM
  8. Betsholtz C
  9. Armulik A
  10. Sallstrom J
  11. Berk BC
  12. Zlokovic BV
  Author Correction: Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.; Nature. 2023 May 05.
• 1. McQuaid C
  2. Solorzano A
  3. Dickerson I
  4. Deane R
  Uptake of severe acute respiratory syndrome coronavirus 2 spike protein mediated by angiotensin converting enzyme 2 and ganglioside in human cerebrovascular cells.; Frontiers in neuroscience; Vol 17, pp. 1117845. 2023 Feb 16.
• 1. Brady M
  2. McQuaid C
  3. Solorzano A
  4. Johnson A
  5. Combs A
  6. Venkatraman C
  7. Rahman A
  8. Leyva H
  9. Kwok WE
  10. Wood RW
  11. Deane R
  Spike protein multiorgan tropism suppressed by antibodies targeting SARS-CoV-2.; Communications biology; Vol 4(1). 2021 Nov 22.
• 1. Deane R
  Response to the letter, entitled "Role of hemagglutinin esterase protein in neurological manifestation of COVID-19".; Fluids and barriers of the CNS; Vol 18(1). 2021 Sep 03.
• 1. McQuaid C
  2. Brady M
  3. Deane R
  SARS-CoV-2: is there neuroinvasion?; Fluids and barriers of the CNS; Vol 18(1). 2021 Jul 14.
• 1. Brady M
  2. Rahman A
  3. Combs A
  4. Venkatraman C
  5. Kasper RT
  6. McQuaid C
  7. Kwok WE
  8. Wood RW
  9. Deane R
  Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging.; Fluids and barriers of the CNS; Vol 17(1). 2020 Nov 30.
• 1. Achariyar TM
  2. Li B
  3. Peng W
  4. Verghese PB
  5. Shi Y
  6. McConnell E
  7. Benraiss A
  8. Kasper T
  9. Song W
  10. Takano T
  11. Holtzman DM
  12. Nedergaard M
  13. Deane R
  Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.; Molecular neurodegeneration; Vol 12(1). 2017 Jan 12.
• 1. Achariyar TM
  2. Li B
  3. Peng W
  4. Verghese PB
  5. Shi Y
  6. McConnell E
  7. Benraiss A
  8. Kasper T
  9. Song W
  10. Takana T
  11. Holtzman DM
  12. Nedergaard M
  13. Deane R
  Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.; Molecular neurodegeneration; Vol 11(1). 2016 Dec 08.
• 1. Lundgaard I
  2. Lu ML
  3. Yang E
  4. Peng W
  5. Mestre H
  6. Hitomi E
  7. Deane R
  8. Nedergaard M
  Glymphatic clearance controls state-dependent changes in brain lactate concentration.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Aug 1.
• 1. Peng W
  2. Achariyar TM
  3. Li B
  4. Liao Y
  5. Mestre H
  6. Hitomi E
  7. Regan S
  8. Kasper T
  9. Peng S
  10. Ding F
  11. Benveniste H
  12. Nedergaard M
  13. Deane R
  Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease.; Neurobiology of disease. 2016 May 24.
• 1. Lee H
  2. Xie L
  3. Yu M
  4. Kang H
  5. Feng T
  6. Deane R
  7. Logan J
  8. Nedergaard M
  9. Benveniste H
  The Effect of Body Posture on Brain Glymphatic Transport.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(31). 2015 Aug 5.
• 1. Plog BA
  2. Dashnaw ML
  3. Hitomi E
  4. Peng W
  5. Liao Y
  6. Lou N
  7. Deane R
  8. Nedergaard M
  Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(2). 2015 Jan 14.
• 1. Iliff JJ
  2. Chen MJ
  3. Plog BA
  4. Zeppenfeld DM
  5. Soltero M
  6. Yang L
  7. Singh I
  8. Deane R
  9. Nedergaard M
  Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 34(49). 2014 Dec 03.
• 1. Kress BT
  2. Iliff JJ
  3. Xia M
  4. Wang M
  5. Wei HS
  6. Zeppenfeld D
  7. Xie L
  8. Kang H
  9. Xu Q
  10. Liew JA
  11. Plog BA
  12. Ding F
  13. Deane R
  14. Nedergaard M
  Impairment of paravascular clearance pathways in the aging brain.; Annals of neurology; Vol 76(6). 2014 Dec.
• 1. Petraglia AL
  2. Plog BA
  3. Dayawansa S
  4. Chen M
  5. Dashnaw ML
  6. Czerniecka K
  7. Walker CT
  8. Viterise T
  9. Hyrien O
  10. Iliff JJ
  11. Deane R
  12. Nedergaard M
  13. Huang JH
  The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy.; Journal of neurotrauma; Vol 31(13). 2014 Jul 01.
• 1. Lundgaard I
  2. Li B
  3. Xie L
  4. Kang H
  5. Sanggaard S
  6. Haswell JD
  7. Sun W
  8. Goldman S
  9. Blekot S
  10. Nielsen M
  11. Takano T
  12. Deane R
  13. Nedergaard M
  Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.; Nature communications; Vol 6. 2015.
• 1. Petraglia AL
  2. Plog BA
  3. Dayawansa S
  4. Dashnaw ML
  5. Czerniecka K
  6. Walker CT
  7. Chen M
  8. Hyrien O
  9. Iliff JJ
  10. Deane R
  11. Huang JH
  12. Nedergaard M
  The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy.; Surgical neurology international; Vol 5. 2014.
• 1. Iliff JJ
  2. Wang M
  3. Zeppenfeld DM
  4. Venkataraman A
  5. Plog BA
  6. Liao Y
  7. Deane R
  8. Nedergaard M
  Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 33(46). 2013 Nov 13.
• 1. Xie L
  2. Kang H
  3. Xu Q
  4. Chen MJ
  5. Liao Y
  6. Thiyagarajan M
  7. O'Donnell J
  8. Christensen DJ
  9. Nicholson C
  10. Iliff JJ
  11. Takano T
  12. Deane R
  13. Nedergaard M
  Sleep drives metabolite clearance from the adult brain.; Science (New York, N.Y.); Vol 342(6156). 2013 Oct 18.
• 1. Singh I
  2. Sagare AP
  3. Coma M
  4. Perlmutter D
  5. Gelein R
  6. Bell RD
  7. Deane RJ
  8. Zhong E
  9. Parisi M
  10. Ciszewski J
  11. Kasper RT
  12. Deane R
  Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance.; Proceedings of the National Academy of Sciences of the United States of America; Vol 110(36). 2013 Sep 03.
• 1. Rangroo Thrane V
  2. Thrane AS
  3. Plog BA
  4. Thiyagarajan M
  5. Iliff JJ
  6. Deane R
  7. Nagelhus EA
  8. Nedergaard M
  Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain.; Scientific reports; Vol 3. 2013.
• 1. Iliff JJ
  2. Wang M
  3. Liao Y
  4. Plogg BA
  5. Peng W
  6. Gundersen GA
  7. Benveniste H
  8. Vates GE
  9. Deane R
  10. Goldman SA
  11. Nagelhus EA
  12. Nedergaard M
  A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.; Science translational medicine; Vol 4(147). 2012 Aug 15.
• 1. Bell RD
  2. Winkler EA
  3. Singh I
  4. Sagare AP
  5. Deane R
  6. Wu Z
  7. Holtzman DM
  8. Betsholtz C
  9. Armulik A
  10. Sallstrom J
  11. Berk BC
  12. Zlokovic BV
  Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.; Nature; Vol 485(7399). 2012 May 16.
• 1. Deane R
  2. Singh I
  3. Sagare AP
  4. Bell RD
  5. Ross NT
  6. LaRue B
  7. Love R
  8. Perry S
  9. Paquette N
  10. Deane RJ
  11. Thiyagarajan M
  12. Zarcone T
  13. Fritz G
  14. Friedman AE
  15. Miller BL
  16. Zlokovic BV
  A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease.; The Journal of clinical investigation; Vol 122(4). 2012 Apr.
• 1. Polesskaya O
  2. Silva J
  3. Sanfilippo C
  4. Desrosiers T
  5. Sun A
  6. Shen J
  7. Feng C
  8. Polesskiy A
  9. Deane R
  10. Zlokovic B
  11. Kasischke K
  12. Dewhurst S
  Methamphetamine causes sustained depression in cerebral blood flow.; Brain research; Vol 1373. 2011 Feb 10.
• 1. Sagare AP
  2. Deane R
  3. Zetterberg H
  4. Wallin A
  5. Blennow K
  6. Zlokovic BV
  Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease.; Journal of Alzheimer's disease : JAD; Vol 24(1). 2011.
• 1. Zlokovic BV
  2. Deane R
  3. Sagare AP
  4. Bell RD
  5. Winkler EA
  Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain.; Journal of neurochemistry; Vol 115(5). 2010 Dec.
• 1. Bell RD
  2. Winkler EA
  3. Sagare AP
  4. Singh I
  5. LaRue B
  6. Deane R
  7. Zlokovic BV
  Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging.; Neuron; Vol 68(3). 2010 Nov 04.
• 1. Zhu D
  2. Wang Y
  3. Singh I
  4. Bell RD
  5. Deane R
  6. Zhong Z
  7. Sagare A
  8. Winkler EA
  9. Zlokovic BV
  Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.; Blood; Vol 115(23). 2010 Jun 10.
• 1. Menon P
  2. Deane R
  3. Sagare A
  4. Lane SM
  5. Zarcone TJ
  6. O'Dell MR
  7. Yan C
  8. Zlokovic BV
  9. Berk BC
  Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice.; Brain research; Vol 1317. 2010 Mar 4.
• 1. Zhong Z
  2. Ilieva H
  3. Hallagan L
  4. Bell R
  5. Singh I
  6. Paquette N
  7. Thiyagarajan M
  8. Deane R
  9. Fernandez JA
  10. Lane S
  11. Zlokovic AB
  12. Liu T
  13. Griffin JH
  14. Chow N
  15. Castellino FJ
  16. Stojanovic K
  17. Cleveland DW
  18. Zlokovic BV
  Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.; The Journal of clinical investigation; Vol 119(11). 2009 Nov.
• 1. Deane R
  2. Bell RD
  3. Sagare A
  4. Zlokovic BV
  Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease.; CNS & neurological disorders drug targets; Vol 8(1). 2009 Mar.
• 1. Guo H
  2. Singh I
  3. Wang Y
  4. Deane R
  5. Barrett T
  6. Fernández JA
  7. Chow N
  8. Griffin JH
  9. Zlokovic BV
  Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity.; The European journal of neuroscience; Vol 29(6). 2009 Mar.
• 1. Bell RD
  2. Deane R
  3. Chow N
  4. Long X
  5. Sagare A
  6. Singh I
  7. Streb JW
  8. Guo H
  9. Rubio A
  10. Van Nostrand W
  11. Miano JM
  12. Zlokovic BV
  SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells.; Nature cell biology; Vol 11(2). 2009 Feb.
• 1. Deane R
  2. LaRue B
  3. Sagare AP
  4. Castellino FJ
  5. Zhong Z
  6. Zlokovic BV
  Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism; Vol 29(1). 2009 Jan.
• 1. Deane R
  2. Sagare A
  3. Hamm K
  4. Parisi M
  5. Lane S
  6. Finn MB
  7. Holtzman DM
  8. Zlokovic BV
  apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.; The Journal of clinical investigation; Vol 118(12). 2008 Dec.
• 1. Zhong Z
  2. Deane R
  3. Ali Z
  4. Parisi M
  5. Shapovalov Y
  6. O'Banion MK
  7. Stojanovic K
  8. Sagare A
  9. Boillee S
  10. Cleveland DW
  11. Zlokovic BV
  ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.; Nature neuroscience; Vol 11(4). 2008 Apr.
• 1. Deane R
  2. Sagare A
  3. Zlokovic BV
  The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease.; Current pharmaceutical design; Vol 14(16). 2008.
• 1. Sagare A
  2. Deane R
  3. Bell RD
  4. Johnson B
  5. Hamm K
  6. Pendu R
  7. Marky A
  8. Lenting PJ
  9. Wu Z
  10. Zarcone T
  11. Goate A
  12. Mayo K
  13. Perlmutter D
  14. Coma M
  15. Zhong Z
  16. Zlokovic BV
  Clearance of amyloid-beta by circulating lipoprotein receptors.; Nature medicine; Vol 13(9). 2007 Sep.
• 1. Bell RD
  2. Sagare AP
  3. Friedman AE
  4. Bedi GS
  5. Holtzman DM
  6. Deane R
  7. Zlokovic BV
  Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism; Vol 27(5). 2007 May.
• 1. Deane R
  2. Zlokovic BV
  Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease.; Current Alzheimer research; Vol 4(2). 2007 Apr.
• 1. Takano T
  2. Han X
  3. Deane R
  4. Zlokovic B
  5. Nedergaard M
  Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease.; Annals of the New York Academy of Sciences; Vol 1097. 2007 Feb.
• 1. Chow N
  2. Bell RD
  3. Deane R
  4. Streb JW
  5. Chen J
  6. Brooks A
  7. Van Nostrand W
  8. Miano JM
  9. Zlokovic BV
  Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.; Proceedings of the National Academy of Sciences of the United States of America; Vol 104(3). 2007 Jan 16.
• 1. Deane R
  2. Zlokovic BV
  Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease; Current Alzheimer's Research; Vol 4, pp. 191-197. 2007 Jan 01.
• 1. Sagare A
  2. Friedman AE
  3. Bedi G
  4. Deane R
  5. Zlokovic BV
  Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J.; J Cerebral Blood flow and Metabolism; Vol 27, pp. 909-918. 2007 Jan 01.
• 1. Deane R
  2. Zlokovic BV
  Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease; Current Alzheimer's Research; Vol 4, pp. 191-197. 2007 Jan 01.
• 1. Kassem NA
  2. Deane R
  3. Segal MB
  4. Preston JE
  Role of transthyretin in thyroxine transfer from cerebrospinal fluid to brain and choroid plexus; American Journal of Physiology - Regulatory Integrative & Comparative Physiology; Vol 291(5), pp. 1310-1315. 2006 Jan 01.
• 1. Cheng T
  2. Petraglia AL
  3. Li Z
  4. Thiyagarajan M
  5. Zhong Z
  6. Wu Z
  7. Liu D
  8. Maggirwar SB
  9. Deane R
  10. Fernández JA
  11. LaRue B
  12. Griffin JH
  13. Chopp M
  14. Zlokovic BV
  Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage.; Nature medicine; Vol 12(11). 2006 Nov.
• 1. Deane R
  2. Sagare A
  3. Hamm K
  4. Parisi M
  5. LaRue B
  6. Guo H
  7. Wu Z
  8. Holtzman DM
  9. Zlokovic BV
  IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 25(50). 2005 Dec 14.
• 1. Cirrito JR
  2. Deane R
  3. Fagan AM
  4. Spinner ML
  5. Parsadanian M
  6. Finn MB
  7. Jiang H
  8. Prior JL
  9. Sagare A
  10. Bales KR
  11. Paul SM
  12. Zlokovic BV
  13. Piwnica-Worms D
  14. Holtzman DM
  P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model.; The Journal of clinical investigation; Vol 115(11). 2005 Nov.