URMC / Labs / Brookes Lab / Publications

Recent Publications

1. Sharma S
2. Rodems BJ
3. Baker CD
4. Kaszuba CM
5. Franco EI
6. Smith BR
7. Ito T
8. Swovick K
9. Welle K
10. Zhang Y
11. Rock P
12. Chaves FA
13. Ghaemmaghami S
14. Calvi LM
15. Ganguly A
16. Burack WR
17. Becker MW
18. Liesveld JL
19. Brookes PS
20. Munger JC
21. Jordan CT
22. Ashton JM
23. Bajaj J
Taurine from tumour niche drives glycolysis to promote leukaemogenesis.; Nature. 2025 May 14.
1. Brookes PS
Misconduct Detection - Evolving Methods & Lessons from 15 Years of Scientific Image Sleuthing.; The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics. 2025 Mar 27.
1. Casso-Chapa B
2. Vazquez González NA
3. Le NT
4. Palaskas NL
5. Nead KT
6. Eutsey LP
7. Samanthapudi VSK
8. Osborn AM
9. Lee J
10. Mejia G
11. Hoang O
12. Lin SH
13. Deswal A
14. Herrmann J
15. Wang G
16. Kirkland JL
17. Krishnan S
18. Wehrens XHT
19. Chini EN
20. Yusuf SW
21. Iliescu CA
22. Jain A
23. Burks JK
24. Seeley E
25. Lorenzi PL
26. Chau KM
27. Ostos Mendoza KC
28. Grumbach IM
29. Brookes PS
30. Hanssen NMJ
31. de Winther MPJ
32. Yvan-Charvet L
33. Kotla S
34. Schadler K
35. Abe JI
Reevaluating Anti-Inflammatory Therapy: Targeting Senescence to Balance Anti-Cancer Efficacy and Vascular Disease.; Arteriosclerosis, thrombosis, and vascular biology. 2025 Jan 16.
1. Catheline SE
2. Smith CO
3. McArthur M
4. Yu C
5. Brookes PS
6. Eliseev RA
Energy metabolism in osteoprogenitors and osteoblasts: role of the Pentose Phosphate Pathway.; The Journal of biological chemistry. 2024 Nov 26.
1. Cohen ED
2. Roethlin K
3. Yee M
4. Woeller CF
5. Brookes PS
6. Porter GA
7. O'Reilly MA
PPARγ drives mitochondrial stress signaling and the loss of atrial cardiomyocytes in newborn mice exposed to hyperoxia.; Redox biology; Vol 76, pp. 103351. 2024 Sep 12.
1. Faniyan TS
2. Zhang X
3. Morgan DA
4. Robles J
5. Bathina S
6. Brookes PS
7. Rahmouni K
8. Perry RJ
9. Chhabra KH
A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria.; eLife; Vol 12. 2024 Jul 31.
1. Jeon KI
2. Kumar A
3. Brookes PS
4. Nehrke K
5. Huxlin KR
Manipulating mitochondrial pyruvate carrier function causes metabolic remodeling in corneal myofibroblasts that ameliorates fibrosis.; Redox biology; Vol 75, pp. 103235. 2024 Jun 08.
1. Beutner G
2. Burris JR
3. Collins MP
4. Kulkarni CA
5. Nadtochiy SM
6. de Mesy Bentley KL
7. Cohen ED
8. Brookes PS
9. Porter GA
Coordinated metabolic responses to cyclophilin D deletion in the developing heart.; iScience; Vol 27(3), pp. 109157. 2024 Feb 09.
1. Tabata Fukushima C
2. Dancil IS
3. Clary H
4. Shah N
5. Nadtochiy SM
6. Brookes PS
Reactive oxygen species generation by reverse electron transfer at mitochondrial complex I under simulated early reperfusion conditions.; Redox biology; Vol 70, pp. 103047. 2024 Jan 27.
1. Faniyan TS
2. Zhang X
3. Morgan DA
4. Robles J
5. Bathina S
6. Brookes PS
7. Rahmouni K
8. Perry RJ
9. Chhabra KH
A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria.; bioRxiv : the preprint server for biology. 2023 Sep 05.
1. Mia S
2. Sonkar R
3. Williams L
4. Latimer MN
5. Rawnsley DR
6. Rana S
7. He J
8. Dierickx P
9. Kim T
10. Xie M
11. Habegger KM
12. Kubo M
13. Zhou L
14. Thomsen MB
15. Prabhu SD
16. Frank SJ
17. Brookes PS
18. Lazar MA
19. Diwan A
20. Young ME
Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology.; JACC. Basic to translational science; Vol 8(9), pp. 1141-1156. 2023 Jun 14.
1. Sautchuk R
2. Yu C
3. McArthur M
4. Massie C
5. Brookes PS
6. Porter GA
7. Awad H
8. Eliseev RA
ROLE OF THE MITOCHONDRIAL PERMEABILITY TRANSITION IN BONE METABOLISM AND AGING.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2023 Feb 13.
1. Fukushima CT
2. Dancil IS
3. Clary H
4. Shah N
5. Nadtochiy SM
6. Brookes PS
Reactive Oxygen Species Generation by Reverse Electron Transfer at Mitochondrial Complex I Under Simulated Early Reperfusion Conditions.; bioRxiv : the preprint server for biology. 2023 Jan 21.
1. Paine A
2. Brookes PS
3. Bhattacharya S
4. Li D
5. Garcia-Hernandez ML
6. Tausk F
7. Ritchlin C
Dysregulation of bile acids, lipids, and nucleotides in psoriatic arthritis revealed by unbiased profiling of serum metabolites.; Arthritis & rheumatology (Hoboken, N.J.). 2022 Jul 11.
1. Milliken AS
2. Nadtochiy SM
3. Brookes PS
Inhibiting Succinate Release Worsens Cardiac Reperfusion Injury by Enhancing Mitochondrial Reactive Oxygen Species Generation.; Journal of the American Heart Association. 2022 Jun 29.
1. Milliken AS
2. Ciesla JH
3. Nadtochiy SM
4. Brookes PS
Distinct effects of intracellular vs. extracellular acidic pH on the cardiac metabolome during ischemia and reperfusion.; Journal of molecular and cellular cardiology; Vol 174, pp. 101-114. 2022 Jan 05.
1. Kotla S
2. Zhang A
3. Imanishi M
4. Ko KA
5. Lin SH
6. Gi YJ
7. Moczygemba M
8. Isgandarova S
9. Schadler KL
10. Chung C
11. Milgrom SA
12. Banchs J
13. Yusuf SW
14. Amaya DN
15. Guo H
16. Thomas TN
17. Shen YH
18. Deswal A
19. Herrmann J
20. Kleinerman ES
21. Entman ML
22. Cooke JP
23. Schifitto G
24. Maggirwar SB
25. McBeath E
26. Gupte AA
27. Krishnan S
28. Patel ZS
29. Yoon Y
30. Burks JK
31. Fujiwara K
32. Brookes PS
33. Le NT
34. Hamilton DJ
35. Abe JI
Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation.; Redox biology; Vol 47. 2021 Sep 20.
1. Brookes PS
2. Jimenez AG
Metabolomics of aging in primary fibroblasts from small and large breed dogs.; GeroScience. 2021 Jun 16.
1. Cohen ED
2. Yee M
3. Porter GA
4. Ritzer EE
5. McDavid AN
6. Brookes PS
7. Pryhuber GS
8. O'Reilly MA
Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis.; JCI insight. 2021 Jan 28.
1. Lim Y
2. Berry B
3. Viteri S
4. McCall M
5. Park EC
6. Rongo C
7. Brookes PS
8. Nehrke K
FNDC-1-Mediated Mitophagy and ATFS-1 Coordinate to Protect Against Hypoxia-Reoxygenation.; Autophagy. 2021 Jan 08.
1. Nadtochiy SM
2. Ngai M
3. Brookes PS
Modified Blue Native Gel Approach for Analysis of Respiratory Supercomplexes.; Methods in molecular biology (Clifton, N.J.); Vol 2276. 2021.
1. Trippier PC
2. Huwaimel BI
3. Bhakta M
4. Kulkarni CA
5. Milliken AS
6. Wang F
7. Peng A
8. Brookes PS
Discovery of Halogenated Benzothiadiazine Derivatives with Anticancer Activity.; ChemMedChem. 2020 Dec 16.
1. Milliken AS
2. Kulkarni CA
3. Brookes PS
Acid enhancement of ROS generation by complex-I reverse electron transport is balanced by acid inhibition of complex-II: Relevance for tissue reperfusion injury.; Redox biology; Vol 37. 2020 Sep 19.
1. Kulkarni CA
2. Nadtochiy SM
3. Kennedy L
4. Zhang J
5. Chhim S
6. Alwaseem H
7. Murphy E
8. Fu D
9. Brookes PS
ALKBH7 mediates necrosis via rewiring of glyoxal metabolism.; eLife; Vol 9. 2020 Aug 14.
1. Milliken AS
2. Brookes PS
Amber Alert: Getting to the Heart of Succinate Efflux in Reperfusion Injury.; Cardiovascular research. 2020 Jul 14.
1. Bennett JA
2. Mastrangelo MA
3. Ture SK
4. Smith CO
5. Loelius SG
6. Berg RA
7. Shi X
8. Burke RM
9. Spinelli SL
10. Cameron SJ
11. Carey TE
12. Brookes PS
13. Gerszten RE
14. Sabater-Lleal M
15. de Vries PS
16. Huffman JE
17. Smith NL
18. Morrell CN
19. Lowenstein CJ
The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function.; Nature communications; Vol 11(1). 2020 Jul 13.
1. Zuurbier CJ
2. Bertrand L
3. Beauloye CR
4. Andreadou I
5. Ruiz-Meana M
6. Jespersen NR
7. Kula-Alwar D
8. Prag HA
9. Eric Botker H
10. Dambrova M
11. Montessuit C
12. Kaambre T
13. Liepinsh E
14. Brookes PS
15. Krieg T
Cardiac metabolism as a driver and therapeutic target of myocardial infarction.; Journal of cellular and molecular medicine. 2020 May 08.
1. Chapa-Dubocq XR
2. Rodríguez-Graciani KM
3. Guzmán-Hernández RA
4. Jang S
5. Brookes PS
6. Javadov S
Cardiac Function is not Susceptible to Moderate Disassembly of Mitochondrial Respiratory Supercomplexes.; International journal of molecular sciences; Vol 21(5). 2020 Feb 25.
1. Dylag AM
2. Brookes PS
3. O'Reilly MA
Swapping mitochondria: A key to understanding susceptibility to neonatal chronic lung disease.; American journal of physiology. Lung cellular and molecular physiology. 2019 Oct 09.
1. Lim Y
2. Rubio-Peña K
3. Sobraske PJ
4. Molina PA
5. Brookes PS
6. Galy V
7. Nehrke K
Fndc-1 contributes to paternal mitochondria elimination in C. elegans.; Developmental biology; Vol 454(1). 2019 Oct 01.
1. Kulkarni CA
2. Brookes PS
Cellular Compartmentation and the Redox/Nonredox Functions of NAD.; Antioxidants & redox signaling; Vol 31(9). 2019 Sep 20.
1. Burke CG
2. Myers JR
3. Boule LA
4. Post CM
5. Brookes PS
6. Lawrence BP
Early life exposures shape the CD4+ T cell transcriptome, influencing proliferation, differentiation, and mitochondrial dynamics later in life.; Scientific reports; Vol 9(1). 2019 Aug 07.
1. Wang YT
2. Lim Y
3. McCall MN
4. Huang KT
5. Haynes CM
6. Nehrke K
7. Brookes PS
Cardioprotection by the mitochondrial unfolded protein response requires ATF5.; American journal of physiology. Heart and circulatory physiology; Vol 317(2). 2019 Aug 01.
1. Nadtochiy SM
2. Wang YT
3. Nehrke K
4. Munger J
5. Brookes PS
Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH.; Journal of molecular and cellular cardiology. 2018 Jun 26.
1. Smith CO
2. Wang YT
3. Nadtochiy SM
4. Miller JH
5. Jonas EA
6. Dirksen RT
7. Nehrke K
8. Brookes PS
Cardiac metabolic effects of KNa1.2 channel deletion and evidence for its mitochondrial localization.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2018 Jun 04.
1. Zhang J
2. Wang YT
3. Miller JH
4. Day MM
5. Munger JC
6. Brookes PS
Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity.; Cell reports; Vol 23(9). 2018 May 29.
1. Peoples JNR
2. Maxmillian T
3. Le Q
4. Nadtochiy SM
5. Brookes PS
6. Porter GA
7. Davidson VL
8. Ebert SN
Metabolomics reveals critical adrenergic regulatory checkpoints in glycolysis and pentose-phosphate pathways in embryonic heart.; The Journal of biological chemistry; Vol 293(18). 2018 May 04.
1. Sahni PV
2. Zhang J
3. Sosunov S
4. Galkin A
5. Niatsetskaya Z
6. Starkov A
7. Brookes PS
8. Ten VS
Krebs cycle metabolites and preferential succinate oxidation following neonatal hypoxic-ischemic brain injury in mice.; Pediatric research; Vol 83(2). 2018 Feb.
1. Resseguie EA
2. Brookes PS
3. O'Reilly MA
SMG-1 kinase attenuates mitochondrial ROS production but not cell respiration deficits during hyperoxia.; Experimental lung research. 2017 Jul 27.
1. Wang H
2. Huwaimel B
3. Verma K
4. Miller J
5. Germain TM
6. Kinarivala N
7. Pappas D
8. Brookes PS
9. Trippier PC
Synthesis and Antineoplastic Evaluation of Mitochondrial Complex II (Succinate Dehydrogenase) Inhibitors Derived from Atpenin A5.; ChemMedChem; Vol 12(13). 2017 Jul 06.
1. Nadtochiy SM
2. Wang YT
3. Zhang J
4. Nehrke K
5. Schafer X
6. Welle K
7. Ghaemmaghami S
8. Munger J
9. Brookes PS
Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation.; The Biochemical journal. 2017 Jul 03.
1. Smith CO
2. Nehrke K
3. Brookes PS
The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection.; The Biochemical journal; Vol 474(12). 2017 Jun 09.
1. Brookes PS
2. Taegtmeyer H
Metabolism: A Direct Link Between Cardiac Structure and Function.; Circulation; Vol 136(22). 2017 Jan 28.
1. Brand MD
2. Goncalves RL
3. Orr AL
4. Vargas L
5. Gerencser AA
6. Borch Jensen M
7. Wang YT
8. Melov S
9. Turk CN
10. Matzen JT
11. Dardov VJ
12. Petrassi HM
13. Meeusen SL
14. Perevoshchikova IV
15. Jasper H
16. Brookes PS
17. Ainscow EK
Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.; Cell metabolism; Vol 24(4). 2016 Oct 11.
1. Nadtochiy SM
2. Schafer X
3. Fu D
4. Nehrke K
5. Munger J
6. Brookes PS
Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling.; The Journal of biological chemistry; Vol 291(38). 2016 Sep 16.
1. Wojtovich AP
2. Smith CO
3. Urciuoli WR
4. Wang YT
5. Xia XM
6. Brookes PS
7. Nehrke K
Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.; Anesthesiology; Vol 124(5). 2016 May.
1. Pell VR
2. Chouchani ET
3. Murphy MP
4. Brookes PS
5. Krieg T
Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.; Circulation research; Vol 118(5). 2016 Mar 4.
1. Shi X
2. O'Neill MM
3. MacDonnell S
4. Brookes PS
5. Yan C
6. Berk BC
The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.; Journal of cardiovascular pharmacology and therapeutics; Vol 21(2). 2016 Mar.
1. Peña S
2. Sherman T
3. Brookes PS
4. Nehrke K
The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans.; PloS one; Vol 11(7). 2016.
1. Shum LC
2. White NS
3. Nadtochiy SM
4. Bentley KL
5. Brookes PS
6. Jonason JH
7. Eliseev RA
Cyclophilin D Knock-Out Mice Show Enhanced Resistance to Osteoporosis and to Metabolic Changes Observed in Aging Bone.; PloS one; Vol 11(5). 2016.