URMC / Labs / Anolik Lab / Publications Publications Faust HJCheng TYKorsunsky IWatts GFMGal-Oz STTrim WVKongthong SJonsson AHSimmons DPZhang FPadera RChubinskaya SWei KRaychaudhuri SLynch LMoody DBBrenner MB Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis.; Nature communications; Vol 15(1), pp. 9859. 2024 Nov 14. Suresh VCrow MKAnolik JHBridges SLPisetsky DS Highlights from the 2024 Rheumatoid Arthritis Research Summit.; Seminars in arthritis and rheumatism. 2024 Nov 08. Bell RDBrendel MKonnaris MAXiang JOtero MFontana MABai ZKrenitsky DMMeednu NRangel-Moreno JScheel-Toellner DCarr HNayar SMcMurray JDiCarlo EAnolik JHDonlin LTOrange DEKenney HMSchwarz EMFiler AIvashkiv LBWang F Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue.; Nature communications; Vol 15(1), pp. 7503. 2024 Aug 29. Law CWacleche VSCao YPillai ASowerby JHancock BHorisberger ABracero SSkidanova VLi ZAdejoorin IDillon EBenque IJNunez DPSimmons DPKeegan JChen LBaker TBrohawn PZAl-Mossawi HHao LYJones BRao NQu YAlves SEJonsson AHShaw KSVleugels RAMassarotti ECostenbader KHBrenner MBLederer JAHultquist JFChoi JRao DA Publisher Correction: Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus.; Nature. 2024 Jul 26. Law CWacleche VSCao YPillai ASowerby JHancock BHorisberger ABracero SSkidanova VLi ZAdejoorin IDillon EBenque IJNunez DPSimmons DPKeegan JChen LBaker TBrohawn PZAl-Mossawi HHao LYJones BRao NQu YAlves SEJonsson AHShaw KSVleugels RAMassarotti ECostenbader KHBrenner MBLederer JAHultquist JFChoi JRao DA Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus.; Nature. 2024 Jul 10. Dunlap GWagner AMeednu NWang RZhang FEkabe JCJonsson AHWei KSakaue SNathan ABykerk VPDonlin LTGoodman SMFirestein GSBoyle DLHolers VMMoreland LWTabechian DPitzalis CFiler ARaychaudhuri SBrenner MBThakar JMcDavid ARao DAAnolik JH Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium.; Nature communications; Vol 15(1), pp. 4991. 2024 Jun 11. Weinand KSakaue SNathan AJonsson AHZhang FWatts GFMAl Suqri MZhu ZRao DAAnolik JHBrenner MBDonlin LTWei KRaychaudhuri S The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis.; Nature communications; Vol 15(1), pp. 4650. 2024 May 31. Bai ZBartelo NAslam MMurphy EAHale CRBlachere NEParveen SSpolaore EDiCarlo EGravallese EMSmith MHFrank MOJiang CSZhang HPyrgaki CLewis MJSikandar SPitzalis CLesnak JBMazhar KPrice TJMalfait AMMiller REZhang FGoodman SDarnell RBWang FOrange DE Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis.; Science translational medicine; Vol 16(742), pp. eadk3506. 2024 Apr 10. Sakaue SWeinand KIsaac SDey KKJagadeesh KKanai MWatts GFMZhu ZBrenner MBMcDavid ADonlin LTWei KPrice ALRaychaudhuri S Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.; Nature genetics. 2024 Apr 09. Fava ABuyon JMagder LHodgin JRosenberg ADemeke DSRao DAArazi ACelia AIPutterman CAnolik JHBarnas JDall'Era MWofsy DFurie RKamen DKalunian KJames JAGuthridge JAtta MGMonroy Trujillo JFine DClancy RBelmont HMIzmirly PApruzzese WGoldman DBerthier CCHoover PHacohen NRaychaudhuri SDavidson ADiamond BPetri M Urine proteomic signatures of histological class, activity, chronicity, and treatment response in lupus nephritis.; JCI insight; Vol 9(2). 2024 Jan 23. Horisberger AGriffith AKeegan JArazi APulford JMurzin EHoward KHancock BFava ASasaki TGhosh TInamo JBeuschel RCao YPreisinger KGutierrez-Arcelus MEisenhaure TMGuthridge JHoover PJDall'Era MWofsy DKamen DLKalunian KCFurie RBelmont MIzmirly PClancy RHildeman DWoodle ESApruzzese WMcMahon MAGrossman JBarnas JLPayan-Schober FIshimori MWeisman MKretzler MBerthier CCHodgin JBDemeke DSPutterman CBrenner MBAnolik JHRaychaudhuri SHacohen NJames JADavidson APetri MABuyon JPDiamond BZhang FLederer JARao DA Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis.; bioRxiv : the preprint server for biology. 2024 Jan 15. Kang JBShen AZGurajala SNathan ARumker LAguiar VRCValencia CLagattuta KAZhang FJonsson AHYazar SAlquicira-Hernandez JKhalili HAnanthakrishnan ANJagadeesh KDey KDaly MJXavier RJDonlin LTAnolik JHPowell JERao DABrenner MBGutierrez-Arcelus MLuo YSakaue SRaychaudhuri S Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution.; Nature genetics; Vol 55(12), pp. 2255-2268. 2023 Nov 30. Abeles IPalma CMeednu NPayne ASLooney RJAnolik JH B Cell-Directed Therapy in Autoimmunity.; Annual review of immunology. 2023 Nov 27. Zhang FJonsson AHNathan AMillard NCurtis MXiao QGutierrez-Arcelus MApruzzese WWatts GFMWeisenfeld DNayar SRangel-Moreno JMeednu NMarks KEMantel IKang JBRumker LMears JSlowikowski KWeinand KOrange DEGeraldino-Pardilla LDeane KDTabechian DCeponis AFirestein GSMaybury MSahbudin IBen-Artzi AMandelin AMNerviani ALewis MJRivellese FPitzalis CHughes LBHorowitz DDiCarlo EGravallese EMBoyce BFMoreland LWGoodman SMPerlman HHolers VMLiao KPFiler ABykerk VPWei KRao DADonlin LTAnolik JHBrenner MBRaychaudhuri S Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.; Nature; Vol 623(7987), pp. 616-624. 2023 Nov 08. Kenney HMRangel-Moreno JPeng YChen KLBruno JEmbong APritchett EFox JIBecerril-Villanueva EGamboa-Domínguez AQuataert SMuthukrishnan GWood RWKorman BDAnolik JHXing LRitchlin CTSchwarz EMWu CL Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.; Frontiers in immunology; Vol 14, pp. 1237498. 2023 Aug 25. Inamo JKeegan JGriffith AGhosh THorisberger AHoward KPulford JMurzin EHancock BJonsson AHSeifert JFeser MLNorris JMCao YApruzzese WLouis Bridges SBykerk VGoodman SDonlin LFirestein GSPerlman HBathon JMHughes LBTabechian DFiler APitzalis CAnolik JHMoreland LGuthridge JMJames JABrenner MBRaychaudhuri SSparks JAMichael Holers VDeane KDLederer JARao DAZhang F Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis.; bioRxiv : the preprint server for biology. 2023 Jul 04. Weinand KSakaue SNathan AJonsson AHZhang FWatts GFMZhu ZRao DAAnolik JHBrenner MBDonlin LTWei KRaychaudhuri S The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis.; bioRxiv : the preprint server for biology. 2023 Apr 08. Dunlap GWagner AMeednu NZhang FJonsson AHWei KSakaue SNathan ABykerk VPDonlin LTGoodman SMFirestein GSBoyle DLHolers VMMoreland LWTabechian DPitzalis CFiler ARaychaudhuri SBrenner MBMcDavid ARao DAAnolik JH Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium.; bioRxiv : the preprint server for biology. 2023 Mar 21. Kang JBShen AZSakaue SLuo YGurajala SNathan ARumker LAguiar VRCValencia CLagattuta KZhang FJonsson AHYazar SAlquicira-Hernandez JKhalili HAnanthakrishnan ANJagadeesh KDey KDaly MJXavier RJDonlin LTAnolik JHPowell JERao DABrenner MBGutierrez-Arcelus MRaychaudhuri S Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution.; medRxiv : the preprint server for health sciences. 2023 Mar 20. Jonsson AHZhang FDunlap GGomez-Rivas EWatts GFMFaust HJRupani KVMears JRMeednu NWang RKeras GCoblyn JSMassarotti EMTodd DJAnolik JHMcDavid AWei KRao DARaychaudhuri SBrenner MB Granzyme K+ CD8 T cells form a core population in inflamed human tissue.; Science translational medicine; Vol 14(649). 2022 Jun 15. Lerman IBawany FWhitt WEsaa FYon JBabkowski NRapp MBScott GAAnolik JHRichardson CT Prominent B cell signature differentiates discoid from subacute cutaneous lupus erythematosus.; The Journal of investigative dermatology. 2022 May 17. Meednu NRangel-Moreno JZhang FEscalera-Rivera KCorsiero EPrediletto EDiCarlo EGoodman SDonlin LTRaychauduri SBombardieri MPitzalis COrange DEMcDavid AAnolik JH Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression.; Cell reports; Vol 39(5). 2022 May 03. Rangel-Moreno JGarcia-Hernandez MLOwen TBarnard JBecerril-Villanueva EKashyap TArgueta CGamboa-Dominguez ATamir SLandesman YGoldman BIRitchlin CTAnolik JH Small molecule inhibitors of nuclear export ameliorate lupus by modulating plasma cell generation and survival.; Arthritis & rheumatology (Hoboken, N.J.). 2022 Mar 25. Fava ARao DAMohan CZhang TRosenberg AFenaroli PBelmont HMIzmirly PClancy RMonroy Trujillo JFine DArazi ABerthier CCDavidson AJames JADiamond BHacohen NWofsy DRaychaudhuri SApruzzese WBuyon JPetri M Urine Proteomics and Renal Single Cell Transcriptomics Implicate IL-16 in Lupus Nephritis.; Arthritis & rheumatology (Hoboken, N.J.). 2021 Nov 16. Barnas JLAlbrecht JMeednu NAlzamareh DFBaker CMcDavid ALooney RJAnolik JH B Cell Activation and Plasma Cell Differentiation Are Promoted by IFN-λ in Systemic Lupus Erythematosus.; Journal of immunology (Baltimore, Md. : 1950). 2021 Oct 27. Meednu NBarnard JCallahan KCoca AMarston BThiele RTabechian DBolster MCurtis JMackay MGraf JKeating RSmith EBoyle KKeyes-Elstein LWelch BGoldmuntz EAnolik JH Activated peripheral blood B cells in rheumatoid arthritis and relationship to anti-TNF treatment and response: randomized clinical trial for anti-TNF effects on B cells.; Arthritis & rheumatology (Hoboken, N.J.). 2021 Aug 04. Zhang FMears JRShakib LBeynor JIShanaj SKorsunsky INathan ADonlin LTRaychaudhuri S IFN- γ and TNF- α drive a CXCL10 + CCL2 + macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammation.; bioRxiv : the preprint server for biology. 2020 Aug 05. Chen JWRice TABannock JMBielecka AAStrauss JDCatanzaro JRWang HMenard LCAnolik JHPalm NWMeffre E Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition.; Science (New York, N.Y.); Vol 369(6501). 2020 Jul 17. Wei KKorsunsky IMarshall JLGao AWatts GFMMajor TCroft APWatts JBlazar PELange JKThornhill TSFiler ARaza KDonlin LTSiebel CWBuckley CDRaychaudhuri SBrenner MB Notch signalling drives synovial fibroblast identity and arthritis pathology.; Nature. 2020 Apr 22. Jenks SACashman KSZumaquero EMarigorta UMPatel AVWang XTomar DWoodruff MCSimon ZBugrovsky RBlalock ELScharer CDTipton CMWei CLim SSPetri MNiewold TBAnolik JHGibson GEun-Hyung Lee FBoss JMLund FESanz I Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.; Immunity; Vol 52(1). 2020 Jan 14. Barnas JLLooney RJAnolik JH B cell targeted therapies in autoimmune disease.; Current opinion in immunology; Vol 61. 2019 Dec. Mensah KAChen JWSchickel JNIsnardi IYamakawa NVega-Loza AAnolik JHGatti RAGelfand EWMontgomery RRHorowitz MCCraft JEMeffre E Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis.; Science translational medicine; Vol 11(519). 2019 Nov 20. Bocharnikov AVKeegan JWacleche VSCao YFonseka CYWang GMuise ESZhang KXArazi AKeras GLi ZJQu YGurish MFPetri MBuyon JPPutterman CWofsy DJames JAGuthridge JMDiamond BAnolik JHMackey MFAlves SENigrovic PACostenbader KHBrenner MBLederer JARao DA PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21.; JCI insight; Vol 4(20). 2019 Oct 17. Arazi ARao DABerthier CCDavidson ALiu YHoover PJChicoine AEisenhaure TMJonsson AHLi SLieb DJZhang FSlowikowski KBrowne EPNoma ASutherby DSteelman SSmilek DETosta PApruzzese WMassarotti EDall'Era MPark MKamen DLFurie RAPayan-Schober FPendergraft WFMcInnis EABuyon JPPetri MAPutterman CKalunian KCWoodle ESLederer JAHildeman DANusbaum CRaychaudhuri SKretzler MAnolik JHBrenner MBWofsy DHacohen NDiamond B Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis.; Nature immunology; Vol 20(10). 2019 Oct. Dieudonné YGies VGuffroy AKeime CBird AKLiesveld JBarnas JLPoindron VDouiri NSoulas-Sprauel PMartin TMeffre EAnolik JHKorganow AS Transitional B cells in quiescent SLE: An early checkpoint imprinted by IFN.; Journal of autoimmunity; Vol 102. 2019 Aug. Arazi ARao DABerthier CCDavidson ALiu YHoover PJChicoine AEisenhaure TMJonsson AHLi SLieb DJZhang FSlowikowski KBrowne EPNoma ASutherby DSteelman SSmilek DETosta PApruzzese WMassarotti EDall'Era MPark MKamen DLFurie RAPayan-Schober FPendergraft WFMcInnis EABuyon JPPetri MAPutterman CKalunian KCWoodle ESLederer JAHildeman DANusbaum CRaychaudhuri SKretzler MAnolik JHBrenner MBWofsy DHacohen NDiamond B The immune cell landscape in kidneys of patients with lupus nephritis.; Nature immunology; Vol 20(7). 2019 Jul. Gao LOConnell MAllen MLiesveld JMcDavid AAnolik JHLooney RJ Bone marrow mesenchymal stem cells from patients with SLE maintain an interferon signature during in vitro culture.; Cytokine. 2019 May 29. Zhang FWei KSlowikowski KFonseka CYRao DAKelly SGoodman SMTabechian DHughes LBSalomon-Escoto KWatts GFMJonsson AHRangel-Moreno JMeednu NRozo CApruzzese WEisenhaure TMLieb DJBoyle DLMandelin AMBoyce BFDiCarlo EGravallese EMGregersen PKMoreland LFirestein GSHacohen NNusbaum CLederer JAPerlman HPitzalis CFiler AHolers VMBykerk VPDonlin LTAnolik JHBrenner MBRaychaudhuri S Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.; Nature immunology. 2019 May 06. Richardson CTSlack MADhillon GMarcus CZBarnard JPalanichamy ASanz ILooney RJAnolik JH Failure of B Cell Tolerance in CVID.; Frontiers in immunology; Vol 10. 2019. Sun WMeednu NRosenberg ARangel-Moreno JWang VGlanzman JOwen TZhou XZhang HBoyce BFAnolik JHXing L B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation.; Nature communications; Vol 9(1). 2018 Dec 03. Donlin LTRao DAWei KSlowikowski KMcGeachy MJTurner JDMeednu NMizoguchi FGutierrez-Arcelus MLieb DJKeegan JMuskat KHillman JRozo CRicker EEisenhaure TMLi SBrowne EPChicoine ASutherby DNoma ANusbaum CKelly SPernis ABIvashkiv LBGoodman SMRobinson WHUtz PJLederer JAGravallese EMBoyce BFHacohen NPitzalis CGregersen PKFirestein GSRaychaudhuri SMoreland LWHolers VMBykerk VPFiler ABoyle DLBrenner MBAnolik JH Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue; Arthritis research & therapy; Vol 20(1). 2018 Jul 11. Gies VSchickel JNJung SJoublin AGlauzy SKnapp AMSoley APoindron VGuffroy AChoi JYGottenberg JEAnolik JHMartin TSoulas-Sprauel PMeffre EKorganow AS Impaired TLR9 responses in B cells from patients with systemic lupus erythematosus.; JCI insight; Vol 3(5). 2018 Mar 08. Jenks SACashman KSZumaquero EMarigorta UMPatel AVWang XTomar DWoodruff MCSimon ZBugrovsky RBlalock ELScharer CDTipton CMWei CLim SSPetri MNiewold TBAnolik JHGibson GLee FEBoss JMLund FESanz I Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.; Immunity; Vol 49(4). 2018 Jan 16. Bird AKChang MBarnard JGoldman BIMeednu NRangel-Moreno JAnolik JH Neutrophils Slow Disease Progression in Murine Lupus via Modulation of Autoreactive Germinal Centers.; Journal of immunology (Baltimore, Md. : 1950). 2017 Jun 05. Meednu NZhang HOwen TSun WWang VCistrone CRangel-Moreno JXing LAnolik JH Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis.; Arthritis & rheumatology (Hoboken, N.J.); Vol 68(4). 2016 Apr. Rangel-Moreno JTo JYOwen TGoldman BISmrcka AVAnolik JH Inhibition of G protein βγ subunit signaling abrogates nephritis in lupus prone mice.; Arthritis & rheumatology (Hoboken, N.J.). 2016 Mar 18. Bird AKMeednu NAnolik JH New insights into B cell biology in systemic lupus erythematosus and Sjögren's syndrome.; Current opinion in rheumatology; Vol 27(5). 2015 Sep. Adlowitz DGBarnard JBiear JNCistrone COwen TWang WPalanichamy AEzealah ECampbell DWei CLooney RJSanz IAnolik JH Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response.; PloS one; Vol 10(6). 2015. Zhang HHilton MJAnolik JHWelle SLZhao CYao ZLi XWang ZBoyce BFXing L NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB.; The Journal of clinical investigation; Vol 124(7). 2014 Jul. Wang WRangel-Moreno JOwen TBarnard JNevarez SIchikawa HTAnolik JH Long-term B cell depletion in murine lupus eliminates autoantibody-secreting cells and is associated with alterations in the kidney plasma cell niche.; Journal of immunology (Baltimore, Md. : 1950); Vol 192(7). 2014 Apr 1. View All Publications