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Biochemistry & Biophysics

URMC / Biochemistry & Biophysics / People / Faculty

 

Faculty

Primary Faculty
Research Faculty
Secondary Faculty
Emeritus Faculty

Primary Faculty

Paul Boutz
Paul L. Boutz, Ph.D.
Research Interest: Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.
Mark Dumont
Mark E. Dumont, Ph.D.
Research Interest: Signal transduction; membrane protein structure, yeast molecular biology
Dmitri Ermolenko
Dmitri N. Ermolenko, Ph.D.
Research Interest:

Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.

Barry Goldstein
Barry M. Goldstein, M.D., Ph.D.

Research Interest:

Crystallography and structural chemistry of enzyme-ligand interactions.

Elizabeth Grayhack
Elizabeth Grayhack, Ph.D.
Research Interest: Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.
Alan Grossfield
Alan Grossfield, Ph.D.
Research Interest:

Investigating membranes and membrane proteins via computer simulation

Jeffrey Hayes
Jeffrey J. Hayes, Ph.D.
Research Interest: Regulation of transcription, nuclear processes, related to chromatin structure and function
Jermaine Jenkins
Jermaine Jenkins, Ph.D.
Research Interest:

X-ray crystallography and cryo-electron microscopy analysis of RNA and protein-RNA complexes

Clara Kielkopf
Clara L. Kielkopf, Ph.D.
Research Interest: Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Lynne Maquat
Lynne Maquat, Ph.D.
Research Interest:

RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.

David Mathews
David H. Mathews, M.D., Ph.D.
Research Interest: Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Joshua Munger
Joshua C. Munger, Ph.D.
Research Interest: Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Mitchell O'Connell
Mitchell O'Connell, Ph.D.
Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Eric Phizicky
Eric Phizicky, Ph.D.
Research Interest: tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Shalom Rackovsky
Shalom Rackovsky, Ph.D.

Research Interest:

Computational protein biophysics, bioinformatic approaches to protein folding and dynamics, development of novel methods of biomolecular sequence and structure comparison and analysis.

Kyle Swovick
Kyle T. Swovick, PhD

Research Interest:

Mass Spectrometry Resource Laboratory

Eric Wagner
Eric J. Wagner, Ph.D.
Research Interest:

Mechanism and physiological importance of alternative polyadenylation; Integrator Complex and transcriptional control, development and application of next-generation sequencing technologies

Joseph Wedekind
Joseph E. Wedekind, Ph.D.
Research Interest: Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.
Yi-Tao Yu
Yi-Tao Yu, Ph.D.
Research Interest: RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.

Research Faculty

Bogdan Polevoda
Bogdan Polevoda, Ph.D.
Research Interest: The two cotranslational processes, cleavage of N-terminal methionine and N-terminal acetylation (N- acetylation).
Xavier Rambout
Xavier Rambout, PhD
Elena Rustchenko-Bulgac
Elena P. Rustchenko-Bulgac, Ph.D.
Research Interest: Chromosomes instability of human fungal pathogen Candida albicans.
Bradley Smith
Bradley Smith, Ph.D.

Research Interest:

Director of the Metabolomic Resource lab

Hironao Wakabayashi
Hironao Wakabayashi, M.D., Ph.D
Research Interest: Structural and functional analyses of factor VIII

Secondary Faculty

Michael Bulger
Michael D. Bulger, Ph.D.
Research Interest: Chromatin domains and long-range activation by enhancers
Gloria Culver
Gloria Culver, Ph.D.
Research Interest: Assembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.
Chin-To Fong
Chin-To Fong, M.D.

Research Interest: Genetics of orofacial clefts
Hartmut Land
Hartmut Land, Ph.D.
Research Interest: Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Benjamin Miller
Benjamin L. Miller, Ph.D.
Research Interest:

Carbohydrate and protein recognition, molecular design, and biomolecular sensing

Peng Yao
Peng Yao, Ph.D.
Research Interest:

Pathophysiological function and molecular mechanism of new non-coding RNAs and RNA-binding proteins and translational control in cardiac system and cardiovascular disease

Emeritus Faculty

Robert Bambara
Robert A. Bambara, Ph.D.

Research Interest: Human genome stability, DNA damage response, HIV replication and evolution
Scott Butler
Scott Butler, Ph.D.
Research Interest: Regulation of Gene Expression by Targeted Degradation of RNA
Russell Hilf
Russell Hilf, Ph.D.

Research Interest:

Hormone action in mammary cancer; Photodynamic therapy of neoplasia

Mahin Maines
Mahin Maines, Ph.D.

Research Interest:

Heme oxygenases and second messenger gases: CO and NO.

Terry Platt
Terry Platt, Ph.D.

Research Interest:

Molecular mechanisms of gene expression; transcription termination and mRNA 3' and formation in Escherichia coli and yeast; protein-nucleic acid.

Alan Senior
Alan E. Senior, Ph.D.

Research Interest: Multidrug-resistance in cancer; ATP synthesis in bacteria and mitochondria
Harold Smith
Harold C. Smith, Ph.D.

Research Interest:

Msg RNA editing in health and disease