Gail Johnson Lab
Welcome to the Gail Johnson Lab
The primary focus of Dr. Gail Johnson’s research group is on the molecular mechanisms of neurodegeneration. The lab has a longstanding interest in the pathogenic processes in Alzheimer disease, and more recently in stroke and spinal cord injury (SCI). For their studies they use a wide variety of different approaches from in vitro enzyme assays with purified proteins, to studies in whole animals. This broad-based approach allows them to translate what they learn about a process or signaling pathway at the molecular level to the in vivo situation. Each of these 2 areas of research that are ongoing in the lab are discussed briefly below.
Publications
View All Publications- Tau Clearance Reverses Neuronal Dysfunction in Both Young and Aged C. elegans.; bioRxiv : the preprint server for biology. 2025 Jun 25.
- Cyclophilin D (CypD) ablation prevents neurodegenerative and cognitive damage induced by caspase-3 cleaved tau.; Free radical biology & medicine. 2025 Feb 27.
- One BAG doesn't fit all: the differences and similarities of BAG family members in mediating CNS homeostasis.; Biological psychiatry. 2025 Jan 08.
- Tau phosphorylation suppresses oxidative stress-induced mitophagy via FKBP8 receptor modulation.; PloS one; Vol 20(1), pp. e0307358. 2025 Jan 03.
- Pharmacological Inhibition of Astrocytic Transglutaminase 2 Facilitates the Expression of a Neurosupportive Astrocyte Reactive Phenotype in Association with Increased Histone Acetylation.; Biomolecules; Vol 14(12). 2024 Dec 13.
Contact Us
Gail Johnson Lab
601 Elmwood Ave, Box 604
Rochester, NY 14642